HNRNPK - heterogeneous nuclear ribonucleoprotein K Gene

Also Known as AUKS; CSBP; TUNP; HNRPK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3190

About HNRNPK

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,968,083-83,980,615 (from NCBI)

This gene has 34 transcripts (splice variants), 348 orthologues, 12 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 179.3), lymph node (RPKM 145.8) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among Other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]

HNRNPK Products (6)

mRNA Protein Name
NM_001318186.2 NP_001305115.1 heterogeneous nuclear ribonucleoprotein K isoform c
NM_001318187.2 NP_001305116.1 heterogeneous nuclear ribonucleoprotein K isoform d
NM_001318188.2 NP_001305117.1 heterogeneous nuclear ribonucleoprotein K isoform b
NM_002140.5 NP_002131.2 heterogeneous nuclear ribonucleoprotein K isoform a
NM_031262.4 NP_112552.1 heterogeneous nuclear ribonucleoprotein K isoform b
NM_031263.4 NP_112553.1 heterogeneous nuclear ribonucleoprotein K isoform a
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16004877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9651361 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10749975 GOA
Cellular Component GO Annotation Evidence References Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in chromatin IDA
IDA: Inferred from direct assay
20371611 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
33174841 GOA
located in nucleus IDA
IDA: Inferred from direct assay
33174841 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
33174841 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPK Protein Structure

ROKNT

ROKNT: ROKNT (NUC014) domain (1 - 43)

KH_1

KH_1: KH domain (45 - 103)

KH_1

KH_1: KH domain (147 - 209)

KH_1

KH_1: KH domain (389 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein K

  • dC-stretch binding protein

HNRNPK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HNRNPK P61978 RTP5 Homo sapiens Q14D33 25416956
Intra
HNRNPK P61978 RTP5 Homo sapiens Q14D33 25416956
Intra
HNRNPK P61978 RTP5 Homo sapiens Q14D33 25416956
Intra
HNRNPK P61978 ZNF792 Homo sapiens Q3KQV3 25416956
Intra
HNRNPK P61978 ZNF792 Homo sapiens Q3KQV3 25416956
Intra
HNRNPK P61978 ZNF792 Homo sapiens Q3KQV3 25416956
Intra
HNRNPK P61978 C6orf226 Homo sapiens Q5I0X4 25416956
Intra
HNRNPK P61978 MARK4 Homo sapiens Q6IPE9 25416956
Intra
HNRNPK P61978 MARK4 Homo sapiens Q6IPE9 25416956
Intra
HNRNPK P61978 MARK4 Homo sapiens Q6IPE9 25416956
Intra
HNRNPK P61978 q8n9j2_human Homo sapiens Q8N9J2 25416956
Intra
HNRNPK P61978 q8n9j2_human Homo sapiens Q8N9J2 25416956
Intra
HNRNPK P61978 q8n9j2_human Homo sapiens Q8N9J2 25416956
Intra
HNRNPK P61978 PCDHB14 Homo sapiens Q9Y5E9 25416956
Intra
HNRNPK P61978 PCDHB14 Homo sapiens Q9Y5E9 25416956
Intra
HNRNPK P61978 PCDHB14 Homo sapiens Q9Y5E9 25416956
Intra
HNRNPK P61978 JPH3 Homo sapiens Q8WXH2 32814053
Intra
HNRNPK P61978 JPH3 Homo sapiens Q8WXH2 32814053
Intra
HNRNPK P61978 JPH3 Homo sapiens Q8WXH2 32814053
Intra
HNRNPK P61978 PRPF31 Homo sapiens Q8WWY3 25416956
Intra
HNRNPK P61978 PRPF31 Homo sapiens Q8WWY3 25416956
Intra
HNRNPK P61978 PRR3 Homo sapiens P79522 25416956
Intra
HNRNPK P61978 PRR3 Homo sapiens P79522 25416956
Intra
HNRNPK P61978 PRR3 Homo sapiens P79522 25416956
Intra
HNRNPK P61978 YTHDC1 Homo sapiens Q96MU7 25416956
Intra
HNRNPK P61978 YTHDC1 Homo sapiens Q96MU7 25416956
Intra
HNRNPK P61978 DALRD3 Homo sapiens Q5D0E6 25416956
Intra
HNRNPK P61978 RBM3 Homo sapiens P98179 25416956
Intra
HNRNPK P61978 RBM3 Homo sapiens P98179 25416956
Intra
HNRNPK P61978 GRB2 Homo sapiens P62993 25416956
Intra
HNRNPK P61978 QKI Homo sapiens Q96PU8 25416956
Intra
HNRNPK P61978 CIRBP Homo sapiens Q14011 25416956
Intra
HNRNPK P61978 GRB2 Homo sapiens P62993 20936779
Intra
HNRNPK P61978 QKI Homo sapiens Q96PU8 25416956
Intra
HNRNPK P61978 QKI Homo sapiens Q96PU8 16713569
Intra
HNRNPK P61978 CIRBP Homo sapiens Q14011 25416956
Intra
HNRNPK P61978 GRB2 Homo sapiens P62993 25416956
Intra
HNRNPK P61978 QKI Homo sapiens Q96PU8 16189514
Intra
HNRNPK P61978 HNRNPU Homo sapiens Q00839 33174841
Intra
HNRNPK P61978 MATR3 Homo sapiens P43243 25416956
Intra
HNRNPK P61978 MATR3 Homo sapiens P43243 16189514
Intra
HNRNPK P61978 MATR3 Homo sapiens P43243 25416956
Intra
HNRNPK P61978 TP53 Homo sapiens P04637 21821029
Intra
HNRNPK P61978 TP53 Homo sapiens P04637 23092970
Intra
HNRNPK P61978 TARDBP Homo sapiens Q13148 32814053
Intra
HNRNPK P61978 TARDBP Homo sapiens Q13148 32814053
Intra
HNRNPK P61978 TARDBP Homo sapiens Q13148 32814053
Intra
HNRNPK P61978 MDM2 Homo sapiens Q00987 19249676
Intra
HNRNPK P61978 AURKA Homo sapiens O14965 21821029
Intra
HNRNPK P61978 AURKA Homo sapiens O14965 21821029
Intra
HNRNPK P61978 DOCK2 Homo sapiens Q92608 25416956
Intra
HNRNPK P61978 ADRB2 Homo sapiens P07550 28298427
Intra
HNRNPK P61978 ADRB2 Homo sapiens P07550 28298427
Intra
HNRNPK P61978 HNRNPLL Homo sapiens Q8WVV9 25416956
Intra
HNRNPK P61978 HNRNPLL Homo sapiens Q8WVV9 25416956
Intra
HNRNPK P61978 SNRPA Homo sapiens P09012
Y2H
22365833
Intra
HNRNPK P61978 SRC Homo sapiens P12931 17178840
Intra
HNRNPK P61978 SRC Homo sapiens P12931 17178840
Intra
HNRNPK P61978 U2AF1 Homo sapiens Q01081 25416956
Intra
HNRNPK P61978 U2AF1 Homo sapiens Q01081 25416956
Intra
HNRNPK P61978 ZFC3H1 Homo sapiens G3V1X1 25416956
Intra
HNRNPK P61978 ATXN10 Homo sapiens Q9UBB4 32814053
Intra
HNRNPK P61978 ATXN10 Homo sapiens Q9UBB4 32814053
Intra
HNRNPK P61978 ATXN10 Homo sapiens Q9UBB4 32814053
Intra
HNRNPK P61978 NDUFV2 Homo sapiens P19404 32814053
Intra
HNRNPK P61978 NDUFV2 Homo sapiens P19404 32814053
Intra
HNRNPK P61978 NDUFV2 Homo sapiens P19404 32814053
Intra
HNRNPK P61978 SPG7 Homo sapiens Q9UQ90 25416956
Intra
HNRNPK P61978 HNRNPL Homo sapiens P14866 33174841
Intra
HNRNPK P61978 HNRNPL Homo sapiens P14866 33174841
Intra
HNRNPK P61978 HNRNPL Homo sapiens P14866 33174841
Intra
HNRNPK P61978 RASD1 Homo sapiens Q9Y272 25416956
Intra
HNRNPK P61978 RASD1 Homo sapiens Q9Y272 25416956
Intra
HNRNPK P61978 RASD1 Homo sapiens Q9Y272 25416956
Intra
HNRNPK P61978 SORBS3 Homo sapiens O60504 16189514
Intra
HNRNPK P61978 SORBS3 Homo sapiens O60504 25416956
Intra
HNRNPK P61978 RBMX Homo sapiens P38159 16189514
Intra
HNRNPK P61978 RBMX Homo sapiens P38159
Y2H
22365833
Intra
HNRNPK P61978 RBMX Homo sapiens P38159 25416956
Intra
HNRNPK P61978 RBMX Homo sapiens P38159 25416956
Intra
HNRNPK P61978 ABI2 Homo sapiens Q9NYB9 29892012
Intra
HNRNPK P61978 ABI2 Homo sapiens Q9NYB9 25416956
Intra
HNRNPK P61978 GFAP Homo sapiens P14136 32814053
Intra
HNRNPK P61978 GFAP Homo sapiens P14136 32814053
Intra
HNRNPK P61978 GFAP Homo sapiens P14136 32814053
Intra
HNRNPK P61978 FBXL18 Homo sapiens Q96D16 25416956
Intra
HNRNPK P61978 FBXL18 Homo sapiens Q96D16 25416956
Intra
HNRNPK P61978 FBXL18 Homo sapiens Q96D16 25416956
Intra
HNRNPK P61978 AQP5 Homo sapiens P55064 25416956
Intra
HNRNPK P61978 RBM42 Homo sapiens Q9BTD8 16189514
Intra
HNRNPK P61978 TERF2IP Homo sapiens Q9NYB0 21044950
Intra
HNRNPK P61978 TERF2IP Homo sapiens Q9NYB0 21044950
Intra
HNRNPK P61978 PRMT1 Homo sapiens Q99873 19101556
Intra
HNRNPK P61978 PRMT1 Homo sapiens Q99873 19101556
Cross
HNRNPK P61978 C'204L African swine fever virus Q8V1E7 18775702
Cross
HNRNPK P61978 C'204L African swine fever virus Q8V1E7
IF
18775702
Cross
HNRNPK P61978 C'204L African swine fever virus Q8V1E7
Y2H
18775702
Intra
HNRNPK P61978 DBH Homo sapiens P09172 32814053
Intra
HNRNPK P61978 DBH Homo sapiens P09172 32814053
Intra
HNRNPK P61978 DBH Homo sapiens P09172 32814053
Intra
HNRNPK P61978 RBMY1A1 Homo sapiens P0DJD3 25416956
Intra
HNRNPK P61978 RBMY1A1 Homo sapiens P0DJD3 25416956
Intra
HNRNPK P61978 RBMY1F Homo sapiens Q15415 25416956
Intra
HNRNPK P61978 RBMY1F Homo sapiens Q15415 25416956
Intra
HNRNPK P61978 ZNF385C Homo sapiens Q66K41 25416956
Intra
HNRNPK P61978 ZNF385C Homo sapiens Q66K41 25416956
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666 9651361
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666
Y2H
9651361
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666 9651361
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666 9651361
Cross
HNRNPK P61978 P29846-PRO_0000037666 Hepatitis C virus P29846-PRO_0000037666 9651361
Cross: Cross-species interaction Intra: Intraspecies interaction

HNRNPK Antibodies

Cat. No. Product Name Application Reactivity
HY-P81449 hnRNP K Antibody (YA1194) IHC-P Human
HY-P81449A hnRNP K Antibody (YA1194)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Au-Kline Syndrome
  • AUKS

  • Okamoto Syndrome

  • Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome

  • Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation

Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9q21.3 Microdeletion
  • 9q21.3 Microdeletion Syndrome

  • Del(9)(Q21.3)

Spinocerebellar Ataxia 10
  • Spinocerebellar Ataxia Type 10

  • SCA10

  • Spinocerebellar Ataxia-10

  • Ataxia, Spinocerebellar, Type 10

Stomatitis
Mouth Disease
  • Mouth Diseases

  • Mouth Disorders

Colorectal Cancer
  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon

Fragile X Syndrome
  • FXS

  • Martin-Bell Syndrome

  • Fraxa Syndrome

  • Marker X Syndrome

  • X-Linked Mental Retardation And Macroorchidism

  • Fragile X Mental Retardation Syndrome

  • Fra Syndrome

  • Mental Retardation, X-Linked, Associated With Marxq28

  • X-Linked Intellectual Disability And Macroorchidism

  • Frax Syndrome

  • Symptomatic Form Of Fragile X Syndrome In Female Carriers

  • Fragile-X Syndrome

  • Fraxe Syndrome

Hepatocellular Carcinoma
  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour

Ptosis
  • Blepharoptosis

  • Drooping Eyelid

  • Droopy Eyelid

  • Ptosis Of Eyelid

  • Paralysis Of Levator Palpebrae Superioris

Breast Cancer
  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation

Prostate Cancer
  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer

Autism
  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic

Amyotrophic Lateral Sclerosis 1
  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus HNRNPK MGD MGI:99894
Bos taurus HNRNPK VGNC VGNC:29897
Macaca mulatta HNRNPK VGNC VGNC:103271
Felis catus HNRNPK VGNC VGNC:67609
Rattus norvegicus HNRNPK RGD RGD:71058
Canis familiaris HNRNPK VGNC VGNC:54846
Others HNRNPK NCBI