HNRNPK - heterogeneous nuclear ribonucleoprotein K Gene
Also Known as AUKS; CSBP; TUNP; HNRPK
Species: Homo sapiens
About HNRNPK
This gene has 34 transcripts (splice variants), 348 orthologues, 12 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 179.3), lymph node (RPKM 145.8) and 25 other tissues.
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among Other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]
HNRNPK Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001318186.2 | NP_001305115.1 | heterogeneous nuclear ribonucleoprotein K isoform c |
| NM_001318187.2 | NP_001305116.1 | heterogeneous nuclear ribonucleoprotein K isoform d |
| NM_001318188.2 | NP_001305117.1 | heterogeneous nuclear ribonucleoprotein K isoform b |
| NM_002140.5 | NP_002131.2 | heterogeneous nuclear ribonucleoprotein K isoform a |
| NM_031262.4 | NP_112552.1 | heterogeneous nuclear ribonucleoprotein K isoform b |
| NM_031263.4 | NP_112553.1 | heterogeneous nuclear ribonucleoprotein K isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
16004877 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9651361 | GOA |
| enables protein domain specific binding |
IPI
IPI: Inferred from physical interaction
|
10749975 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of DNA-templated transcription |
IMP
IMP: Inferred from mutant phenotype
|
33174841 | GOA |
| acts upstream of or within negative regulation of apoptotic process |
IMP
IMP: Inferred from mutant phenotype
|
20548952 | GOA |
| acts upstream of positive regulation of low-density lipoprotein receptor activity |
IMP
IMP: Inferred from mutant phenotype
|
20371611 | GOA |
| acts upstream of positive regulation of receptor-mediated endocytosis |
IMP
IMP: Inferred from mutant phenotype
|
20371611 | GOA |
| involved in random inactivation of X chromosome |
IDA
IDA: Inferred from direct assay
|
25843628 | GOA |
| acts upstream of regulation of low-density lipoprotein particle clearance |
IMP
IMP: Inferred from mutant phenotype
|
20371611 | GOA |
| involved in regulatory ncRNA-mediated heterochromatin formation |
IMP
IMP: Inferred from mutant phenotype
|
25843628 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of catalytic step 2 spliceosome |
IDA
IDA: Inferred from direct assay
|
11991638 | GOA |
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
20371611 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
33174841 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
33174841 | GOA |
| part of ribonucleoprotein complex |
IDA
IDA: Inferred from direct assay
|
33174841 | GOA |
HNRNPK Protein Structure
ROKNT: ROKNT (NUC014) domain (1 - 43)
KH_1: KH domain (45 - 103)
KH_1: KH domain (147 - 209)
KH_1: KH domain (389 - 450)
- 0
- 100
- 200
- 300
- 400
- 463 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
heterogeneous nuclear ribonucleoprotein K |
|
HNRNPK Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
HNRNPK | P61978 | RTP5 | Homo sapiens | Q14D33 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RTP5 | Homo sapiens | Q14D33 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RTP5 | Homo sapiens | Q14D33 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ZNF792 | Homo sapiens | Q3KQV3 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ZNF792 | Homo sapiens | Q3KQV3 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ZNF792 | Homo sapiens | Q3KQV3 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | C6orf226 | Homo sapiens | Q5I0X4 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | MARK4 | Homo sapiens | Q6IPE9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | MARK4 | Homo sapiens | Q6IPE9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | MARK4 | Homo sapiens | Q6IPE9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | q8n9j2_human | Homo sapiens | Q8N9J2 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | q8n9j2_human | Homo sapiens | Q8N9J2 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | q8n9j2_human | Homo sapiens | Q8N9J2 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | PCDHB14 | Homo sapiens | Q9Y5E9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | PCDHB14 | Homo sapiens | Q9Y5E9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | PCDHB14 | Homo sapiens | Q9Y5E9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | PRPF31 | Homo sapiens | Q8WWY3 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | PRPF31 | Homo sapiens | Q8WWY3 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | PRR3 | Homo sapiens | P79522 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | PRR3 | Homo sapiens | P79522 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | PRR3 | Homo sapiens | P79522 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | YTHDC1 | Homo sapiens | Q96MU7 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | YTHDC1 | Homo sapiens | Q96MU7 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | DALRD3 | Homo sapiens | Q5D0E6 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RBM3 | Homo sapiens | P98179 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RBM3 | Homo sapiens | P98179 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | GRB2 | Homo sapiens | P62993 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | QKI | Homo sapiens | Q96PU8 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | CIRBP | Homo sapiens | Q14011 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | GRB2 | Homo sapiens | P62993 | 20936779 | |
|
Intra
|
HNRNPK | P61978 | QKI | Homo sapiens | Q96PU8 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | QKI | Homo sapiens | Q96PU8 | 16713569 | |
|
Intra
|
HNRNPK | P61978 | CIRBP | Homo sapiens | Q14011 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | GRB2 | Homo sapiens | P62993 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | QKI | Homo sapiens | Q96PU8 | 16189514 | |
|
Intra
|
HNRNPK | P61978 | HNRNPU | Homo sapiens | Q00839 | 33174841 | |
|
Intra
|
HNRNPK | P61978 | MATR3 | Homo sapiens | P43243 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | MATR3 | Homo sapiens | P43243 | 16189514 | |
|
Intra
|
HNRNPK | P61978 | MATR3 | Homo sapiens | P43243 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | TP53 | Homo sapiens | P04637 | 21821029 | |
|
Intra
|
HNRNPK | P61978 | TP53 | Homo sapiens | P04637 | 23092970 | |
|
Intra
|
HNRNPK | P61978 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | MDM2 | Homo sapiens | Q00987 | 19249676 | |
|
Intra
|
HNRNPK | P61978 | AURKA | Homo sapiens | O14965 | 21821029 | |
|
Intra
|
HNRNPK | P61978 | AURKA | Homo sapiens | O14965 | 21821029 | |
|
Intra
|
HNRNPK | P61978 | DOCK2 | Homo sapiens | Q92608 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ADRB2 | Homo sapiens | P07550 | 28298427 | |
|
Intra
|
HNRNPK | P61978 | ADRB2 | Homo sapiens | P07550 | 28298427 | |
|
Intra
|
HNRNPK | P61978 | HNRNPLL | Homo sapiens | Q8WVV9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | HNRNPLL | Homo sapiens | Q8WVV9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | SNRPA | Homo sapiens | P09012 | 22365833 | |
|
Intra
|
HNRNPK | P61978 | SRC | Homo sapiens | P12931 | 17178840 | |
|
Intra
|
HNRNPK | P61978 | SRC | Homo sapiens | P12931 | 17178840 | |
|
Intra
|
HNRNPK | P61978 | U2AF1 | Homo sapiens | Q01081 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | U2AF1 | Homo sapiens | Q01081 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ZFC3H1 | Homo sapiens | G3V1X1 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ATXN10 | Homo sapiens | Q9UBB4 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | ATXN10 | Homo sapiens | Q9UBB4 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | ATXN10 | Homo sapiens | Q9UBB4 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | SPG7 | Homo sapiens | Q9UQ90 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | HNRNPL | Homo sapiens | P14866 | 33174841 | |
|
Intra
|
HNRNPK | P61978 | HNRNPL | Homo sapiens | P14866 | 33174841 | |
|
Intra
|
HNRNPK | P61978 | HNRNPL | Homo sapiens | P14866 | 33174841 | |
|
Intra
|
HNRNPK | P61978 | RASD1 | Homo sapiens | Q9Y272 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RASD1 | Homo sapiens | Q9Y272 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RASD1 | Homo sapiens | Q9Y272 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | SORBS3 | Homo sapiens | O60504 | 16189514 | |
|
Intra
|
HNRNPK | P61978 | SORBS3 | Homo sapiens | O60504 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RBMX | Homo sapiens | P38159 | 16189514 | |
|
Intra
|
HNRNPK | P61978 | RBMX | Homo sapiens | P38159 | 22365833 | |
|
Intra
|
HNRNPK | P61978 | RBMX | Homo sapiens | P38159 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RBMX | Homo sapiens | P38159 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ABI2 | Homo sapiens | Q9NYB9 | 29892012 | |
|
Intra
|
HNRNPK | P61978 | ABI2 | Homo sapiens | Q9NYB9 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | FBXL18 | Homo sapiens | Q96D16 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | FBXL18 | Homo sapiens | Q96D16 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | FBXL18 | Homo sapiens | Q96D16 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | AQP5 | Homo sapiens | P55064 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RBM42 | Homo sapiens | Q9BTD8 | 16189514 | |
|
Intra
|
HNRNPK | P61978 | TERF2IP | Homo sapiens | Q9NYB0 | 21044950 | |
|
Intra
|
HNRNPK | P61978 | TERF2IP | Homo sapiens | Q9NYB0 | 21044950 | |
|
Intra
|
HNRNPK | P61978 | PRMT1 | Homo sapiens | Q99873 | 19101556 | |
|
Intra
|
HNRNPK | P61978 | PRMT1 | Homo sapiens | Q99873 | 19101556 | |
|
Cross
|
HNRNPK | P61978 | C'204L | African swine fever virus | Q8V1E7 | 18775702 | |
|
Cross
|
HNRNPK | P61978 | C'204L | African swine fever virus | Q8V1E7 | 18775702 | |
|
Cross
|
HNRNPK | P61978 | C'204L | African swine fever virus | Q8V1E7 | 18775702 | |
|
Intra
|
HNRNPK | P61978 | DBH | Homo sapiens | P09172 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | DBH | Homo sapiens | P09172 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | DBH | Homo sapiens | P09172 | 32814053 | |
|
Intra
|
HNRNPK | P61978 | RBMY1A1 | Homo sapiens | P0DJD3 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RBMY1A1 | Homo sapiens | P0DJD3 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RBMY1F | Homo sapiens | Q15415 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | RBMY1F | Homo sapiens | Q15415 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ZNF385C | Homo sapiens | Q66K41 | 25416956 | |
|
Intra
|
HNRNPK | P61978 | ZNF385C | Homo sapiens | Q66K41 | 25416956 | |
|
Cross
|
HNRNPK | P61978 | P29846-PRO_0000037666 | Hepatitis C virus | P29846-PRO_0000037666 | 9651361 | |
|
Cross
|
HNRNPK | P61978 | P29846-PRO_0000037666 | Hepatitis C virus | P29846-PRO_0000037666 | 9651361 | |
|
Cross
|
HNRNPK | P61978 | P29846-PRO_0000037666 | Hepatitis C virus | P29846-PRO_0000037666 | 9651361 | |
|
Cross
|
HNRNPK | P61978 | P29846-PRO_0000037666 | Hepatitis C virus | P29846-PRO_0000037666 | 9651361 | |
|
Cross
|
HNRNPK | P61978 | P29846-PRO_0000037666 | Hepatitis C virus | P29846-PRO_0000037666 | 9651361 |
HNRNPK Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81449 | hnRNP K Antibody (YA1194) | IHC-P | Human |
| HY-P81449A | hnRNP K Antibody (YA1194)(PBS only) | IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Au-Kline Syndrome |
|
|
| Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9q21.3 Microdeletion |
|
|
| Spinocerebellar Ataxia 10 |
|
|
| Stomatitis |
|
|
| Mouth Disease |
|
|
| Colorectal Cancer |
|
|
| Fragile X Syndrome |
|
|
| Hepatocellular Carcinoma |
|
|
| Ptosis |
|
|
| Breast Cancer |
|
|
| Prostate Cancer |
|
|
| Autism |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | HNRNPK | MGD | MGI:99894 |
| Bos taurus | HNRNPK | VGNC | VGNC:29897 |
| Macaca mulatta | HNRNPK | VGNC | VGNC:103271 |
| Felis catus | HNRNPK | VGNC | VGNC:67609 |
| Rattus norvegicus | HNRNPK | RGD | RGD:71058 |
| Canis familiaris | HNRNPK | VGNC | VGNC:54846 |
| Others | HNRNPK | NCBI |