AQP5 - aquaporin 5 Gene

Also Known as PPKB; AQP-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 362

About AQP5

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,961,872-49,965,682 (from NCBI)

This gene has 2 transcripts (splice variants), 408 orthologues, 11 paralogues and is associated with 3 phenotypes. Biased expression in salivary gland (RPKM 99.1), testis (RPKM 61.9) and 1 other tissue.

Summary

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]

AQP5 Products (1)

mRNA	Protein	Name
NM_001651.4	NP_001642.1	aquaporin-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18768791	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables water channel activity	IDA IDA: Inferred from direct assay	12801959	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in carbon dioxide transport	IDA IDA: Inferred from direct assay	19273840	GOA
involved in cellular hypotonic response	IDA IDA: Inferred from direct assay	26569106	GOA
involved in odontogenesis	IEP IEP: Inferred from expression pattern	12522663	GOA
involved in pancreatic juice secretion	IEP IEP: Inferred from expression pattern	12801959	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	18768791	GOA
involved in water transport	IDA IDA: Inferred from direct assay	18768791	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12801959	GOA
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	26569106	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26569106	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP5 Protein Structure

MIP

0
100
200
265 a.a.

Protein Preferred Names	Protein Names
aquaporin-5

AQP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AQP5	P55064	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	AQP5	P55064	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
Intra	AQP5	P55064	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	AQP5	P55064	MDFI	Homo sapiens	Q99750	Y2H Pooling	19060904
Intra	AQP5	P55064	MDFI	Homo sapiens	Q99750	Y2H Array	19060904
Intra	AQP5	P55064	MDFI	Homo sapiens	Q99750	Y2H Pooling	16189514
Intra	AQP5	P55064	CREB3	Homo sapiens	O43889-2	Y2H Array	31515488
Intra	AQP5	P55064	ATP6V0A2	Homo sapiens	Q9Y487	Anti Tag CoIP	33961781
Intra	AQP5	P55064	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	AQP5	P55064	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	AQP5	P55064	AQP5	Homo sapiens	P55064	X-Ray Diffraction	18768791
Intra	AQP5	P55064	ATP1A2	Homo sapiens	P50993	Anti Tag CoIP	33961781
Intra	AQP5	P55064	AQP5	Homo sapiens	P55064	GMS	18768791
Intra	AQP5	P55064	ATP6V0A1	Homo sapiens	Q93050	Anti Tag CoIP	33961781
Intra	AQP5	P55064	CREB3	Homo sapiens	O43889	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

AQP5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86785	Aquaporin 5 Antibody (YA6478)	WB, IHC-P, IF-Tissue, mIHC	Human, Mouse

Related Diseases

Diseases	Alias
Palmoplantar Keratoderma, Bothnian Type	PPKB Diffuse Palmoplantar Keratoderma, Bothnian Type Bothnian Type Palmoplantar Keratoderma Keratoderma, Palmoplantar, Bothnian Type Palmoplantar Keratoderma, Nonepidermolytic
Palmoplantar Keratoderma, Nonepidermolytic	Nonepidermolytic Palmoplantar Keratoderma NEPPK Tylosis Unna-Thost Syndrome Keratoderma, Palmoplantar, Diffuse Ppkne Keratoderma, Nonepidermolytic Palmoplantar Diffuse Nonepidermolytic Palmomplantar Keratoderma Thost-Unna Syndrome Non-Epidermolytic Palmoplantar Keratoderma Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type Diffuse Palmoplantar Keratoderma, Bothnian Type Krt1-Related Diffuse Nonepidermolytic Keratoderma Krt1-Related Diffuse Neppk Keratoderma, Palmoplantar, Non-Epidermolytic Nonepidermolytic Unna-Thost Disease Non-Epidermolytic Unna-Thost Disease Keratoderma, Palmoplantar, Nonepidermolytic Hyperkeratosis
Dry Eye Syndrome	Dry Eye Syndromes Dry Eye Disease Tear Film Insufficiency Xerophthalmia
Aplasia Of Lacrimal And Salivary Glands	ALSG Congenital Absence Of Lacrimal Puncta And Salivary Glands Xerostomia Absence Of Salivary Glands Parotid Aplasia Or Hypoplasia Congenital Absence Of Lacrimal Puncta Or Salivary Glands Alsg - [Aplasia Of Lacrimal Or Salivary Glands]
Pulmonary Edema
Neuromyelitis Optica	Devic Disease Devic Syndrome Neuromyelitis Optica Spectrum Disorder Devic'S Disease Devic'S Syndrome Devic'S Neuromyelitis Optica Nmo Nmo Spectrum Disorder Neuromyelitis Optica Spectrum Disorders Devic Neuromyelitis Optica Optic-Spinal Ms Opticospinal Ms Nmosd Opticospinal Multiple Sclerosis Devic Ophthalmoneuromyelitis Optic Neuromyelitis Optic Neuroencephalomyelopathy Nmo - [Neuromyelitis Optica] Optic Neuritis With Demyelination
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Sjogren Syndrome	Sicca Syndrome Sjogren'S Syndrome Sjögren Syndrome Sjogren-Gougerot Syndrome Keratoconjunctivitis Sicca Sjögren'S Syndrome Xerodermosteosis Dacryosialoadenopathia Atrophicans Gougerot-Houwer-Sjogren Syndrome Gougerot-Sjogren Syndrome Keratoconjunctivitis Sicca-Xerostomia Secreto-Inhibitor-Xerodermostenosis Primary Sjogren Syndrome Primary Sjogren-Gougerot Syndrome Sjogrens Syndrome Primary Sjogrens Syndrome Dry Eye Syndromes
Dacryoadenitis	Dacryocystitis
Accommodative Spasm	Spasm Of Accommodation Cyclospasm Ciliary Muscle Spasm Ciliary Body Spasm
Lacrimal Apparatus Disease	Lacrimal Apparatus Diseases
Sialolithiasis	Sialolith Stone Of Salivary Gland Or Duct Salivary Gland Calculi Salivary Gland Stone Calculus Of Salivary Gland Or Duct Calculus Of Salivary Gland Salivary Calculus Salivary Gland Calculus Salivary Stone Salivary Duct Calculi Sialodocholithiasis
Acrokeratoderma, Hereditary Papulotranslucent	Hereditary Papulotranslucent Acrokeratoderma
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Keratoconjunctivitis Sicca	Kcs Dry Eye Syndromes Keratitis Sicca Xerophthalmia
Diffuse Pulmonary Fibrosis
Autoimmune Disease Of Exocrine System
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Presbyopia	Subnormal Accommodation Accommodation Insufficiency Of Old Age
Xerophthalmia	Conjunctival Xerosis
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00877	AQP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AQP5	VGNC	VGNC:57418
Mus musculus	AQP5	MGD	MGI:106215
Felis catus	AQP5	VGNC	VGNC:83497
Rattus norvegicus	AQP5	RGD	RGD:2144
Macaca mulatta	AQP5	VGNC	VGNC:108321
Bos taurus	AQP5	VGNC	VGNC:26048
Others	AQP5	NCBI