CREB3 - cAMP responsive element binding protein 3 Gene

Also Known as LZIP; LUMAN; sLZIP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10488

About CREB3

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,732,666-35,736,999 (from NCBI)

This gene has 2 transcripts (splice variants), 176 orthologues and 9 paralogues. Ubiquitous expression in prostate (RPKM 27.8), testis (RPKM 25.9) and 25 other tissues.

Summary

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV Infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

CREB3 Products (1)

mRNA	Protein	Name
NM_006368.5	NP_006359.3	cyclic AMP-responsive element-binding protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CCR1 chemokine receptor binding	IDA IDA: Inferred from direct assay	15001559	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	9271389	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16940180	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	16940180	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10675342	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16940180	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16940180	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15845366	GOA
enables cAMP response element binding protein binding	IDA IDA: Inferred from direct assay	9271389	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	16940180	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9271389	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10675342	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	11711630	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA-templated transcription	IDA IDA: Inferred from direct assay	9271389	GOA
involved in cytoplasmic sequestering of transcription factor	IDA IDA: Inferred from direct assay	20091349	GOA
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	16940180	GOA
involved in establishment of viral latency	IDA IDA: Inferred from direct assay	20091349	GOA
NOT involved in induction of positive chemotaxis	IDA IDA: Inferred from direct assay	19779205	GOA
involved in induction of positive chemotaxis	IDA IDA: Inferred from direct assay	19779205	GOA
involved in induction of positive chemotaxis	IMP IMP: Inferred from mutant phenotype	15001559	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	16940180	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9271389	GOA
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	15001559	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15001559	GOA
involved in positive regulation of deacetylase activity	IDA IDA: Inferred from direct assay	19779205	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	20091349	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	17296613	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15845366	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16940180	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	16940180	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	20141198	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10675342	GOA
involved in release from viral latency	IDA IDA: Inferred from direct assay	20091349	GOA
NOT involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	15845366	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IMP IMP: Inferred from mutant phenotype	10623756	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	20091349	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18391022	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	10623756	GOA
located in cytosol	IMP IMP: Inferred from mutant phenotype	15001559	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16236796	GOA
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	10623756	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	20091349	GOA
NOT located in membrane	IDA IDA: Inferred from direct assay	19779205	GOA
located in membrane	IDA IDA: Inferred from direct assay	10623756	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	20091349	GOA
located in nuclear body	IDA IDA: Inferred from direct assay	18391022	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10675342	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREB3 Protein Structure

bZIP_1

0
100
200
300
371 a.a.

Protein Preferred Names	Protein Names
cyclic AMP-responsive element-binding protein 3	basic leucine zipper protein

CREB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CREB3	O43889	ALG3	Homo sapiens	Q92685	Y2H Array	31515488
Intra	CREB3	O43889	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	33961781
Intra	CREB3	O43889	HCFC1	Homo sapiens	P51610	Anti Bait CoIP	15705566
Intra	CREB3	O43889	CREB3L3	Homo sapiens	Q68CJ9	Peptide Array	20102225
Intra	CREB3	O43889	CREBZF	Homo sapiens	Q9NS37	Anti Bait CoIP	15705566
Intra	CREB3	O43889	CREB3	Homo sapiens	O43889	FRET	23661758
Intra	CREB3	O43889	CREB3	Homo sapiens	O43889	Y2H	21516116
Intra	CREB3	O43889	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	CREB3	O43889	JUN	Homo sapiens	P05412	TAP	20195357

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Ventricular Tachycardia, Catecholaminergic Polymorphic, 2	Catecholaminergic Polymorphic Ventricular Tachycardia 2 CPVT2 Vtsip Bidirectional Tachycardia Stress-Induced Polymorphic Ventricular Tachycardia Ventricular Tachycardia, Stress-Induced Polymorphic Cvpt2 Double Tachycardia Induced By Catecholamines Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Paroxysmal Ventricular Fibrillation Syncopal Paroxysmal Tachycardia Syncopal Tachyarythmia Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2 Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 Multifocal Pvcs Multifocal Premature Ventricular Beats Paroxysmal Familial Ventricular Fibrillation
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03149	CREB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03150	CREB3L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03151	CREB3L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03152	CREB3L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03153	CREB3L4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17784	Creb3l1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18514	Creb3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24251	Creb3l1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24996	Creb3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CREB3	VGNC	VGNC:71486
Canis familiaris	CREB3	VGNC	VGNC:39596
Felis catus	CREB3	VGNC	VGNC:61165
Rattus norvegicus	CREB3	RGD	RGD:1308831
Mus musculus	CREB3	MGD	MGI:99946
Bos taurus	CREB3	VGNC	VGNC:27693
Others	CREB3	NCBI