DDIT3 - DNA damage inducible transcript 3 Gene

Also Known as CHOP; CEBPZ; CHOP10; CHOP-10; GADD153; AltDDIT3; C/EBPzeta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1649

About DDIT3

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,516,588-57,521,698 (from NCBI)

This gene has 6 transcripts (splice variants), 193 orthologues and is associated with 51 phenotypes. Broad expression in thyroid (RPKM 74.2), bone marrow (RPKM 47.3) and 24 other tissues.

Summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with Other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes Apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

DDIT3 Products (8)

mRNA	Protein	Name
NM_001195053.1	NP_001181982.1	DNA damage-inducible transcript 3 protein isoform 1
NM_001195054.1	NP_001181983.1	DNA damage-inducible transcript 3 protein isoform 1
NM_001195055.1	NP_001181984.1	DNA damage-inducible transcript 3 protein isoform 1
NM_001195056.1	NP_001181985.1	DNA damage-inducible transcript 3 protein isoform 1
NM_001195057.1	NP_001181986.1	DNA damage-inducible transcript 3 protein isoform 2
NM_001413641.1	NP_001400570.1	DNA damage-inducible transcript 3 protein isoform 2
NM_001413642.1	NP_001400571.1	DNA damage-inducible transcript 3 protein isoform 2
NM_004083.6	NP_004074.2	DNA damage-inducible transcript 3 protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14667815	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22065586	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	30639358	GOA
enables DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	24939851	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22065586	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16434966	GOA
enables cAMP response element binding protein binding	IPI IPI: Inferred from physical interaction	11478948	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA
enables leucine zipper domain binding	IDA IDA: Inferred from direct assay	8622660	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15775988	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8622660	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18534616	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	24939851	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	24038088	GOA
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	11478948	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in HRI-mediated signaling	IDA IDA: Inferred from direct assay	32132706	GOA
acts upstream of or within cell redox homeostasis	IDA IDA: Inferred from direct assay	14667815	GOA
involved in integrated stress response signaling	IDA IDA: Inferred from direct assay	30639358	GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	18940792	GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	15322075	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18940792	GOA
involved in negative regulation of determination of dorsal identity	IDA IDA: Inferred from direct assay	16434966	GOA
acts upstream of negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	24038088	GOA
acts upstream of negative regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	24038088	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22761832	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24038088	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16434966	GOA
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	11478948	GOA
acts upstream of negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	24038088	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18534616	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15322075	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	20829347	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27031958	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15322075	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15775988	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22065586	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	17872950	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17872950	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14667815	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8622660	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	18940792	GOA
involved in response to endoplasmic reticulum stress	IGI IGI: Inferred from genetic interaction	15775988	GOA
involved in response to unfolded protein	IDA IDA: Inferred from direct assay	18940792	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CHOP-ATF3 complex	IDA IDA: Inferred from direct assay	8622660	GOA
part of CHOP-ATF4 complex	IDA IDA: Inferred from direct assay	11478948	GOA
part of CHOP-ATF4 complex	IPI IPI: Inferred from physical interaction	18940792	GOA
part of CHOP-C/EBP complex	IPI IPI: Inferred from physical interaction	20102225	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	29083303	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11478948	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	15322075	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDIT3 Protein Structure

bZIP_2

0
100
169 a.a.

Protein Preferred Names	Protein Names
DNA damage-inducible transcript 3 protein	C/EBP zeta

DDIT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DDIT3	P35638	BATF3	Homo sapiens	Q9NR55	Y2H Array	20211142
Intra	DDIT3	P35638	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	DDIT3	P35638	BATF3	Homo sapiens	Q9NR55	Validated Y2H	32296183
Intra	DDIT3	P35638	G3BP1	Homo sapiens	Q13283	FPS	34799561
Intra	DDIT3	P35638	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	DDIT3	P35638	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	DDIT3	P35638	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	DDIT3	P35638	ATF2	Homo sapiens	P15336	FRET	23661758
Intra	DDIT3	P35638	CEBPA	Homo sapiens	P49715	Anti Tag CoIP	33961781
Intra	DDIT3	P35638	CEBPA	Homo sapiens	P49715	FRET	23661758
Intra	DDIT3	P35638	CEBPA	Homo sapiens	P49715	Peptide Array	20102225
Intra	DDIT3	P35638	EMSY	Homo sapiens	Q7Z589-5	Validated Y2H	32296183
Intra	DDIT3	P35638	TXNDC2	Homo sapiens	Q86VQ3	Validated Y2H	32296183
Intra	DDIT3	P35638	JDP2	Homo sapiens	Q8WYK2	Validated Y2H	32296183
Intra	DDIT3	P35638	BACH1	Homo sapiens	O14867	Peptide Array	20102225
Intra	DDIT3	P35638	BACH1	Homo sapiens	O14867	FRET	23661758
Intra	DDIT3	P35638	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	32296183
Intra	DDIT3	P35638	HLF	Homo sapiens	Q16534	FRET	23661758
Intra	DDIT3	P35638	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	DDIT3	P35638	TEDC1	Homo sapiens	Q86SX3	Anti Tag CoIP	33961781
Intra	DDIT3	P35638	TEDC1	Homo sapiens	Q86SX3	Anti Tag CoIP	20562859
Intra	DDIT3	P35638	TEDC1	Homo sapiens	Q86SX3	Y2H	18330356
Intra	DDIT3	P35638	FOSL2	Homo sapiens	P15408	Validated Y2H	27107012
Intra	DDIT3	P35638	DBP	Homo sapiens	Q10586	Y2H Array	21988832
Intra	DDIT3	P35638	DBP	Homo sapiens	Q10586	FRET	23661758
Intra	DDIT3	P35638	NFIL3	Homo sapiens	Q16649	FRET	23661758
Intra	DDIT3	P35638	NFIL3	Homo sapiens	Q16649	Peptide Array	20102225
Intra	DDIT3	P35638	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	DDIT3	P35638	ATF4	Homo sapiens	P18848	Y2H	18330356
Intra	DDIT3	P35638	CREB3	Homo sapiens	O43889	FRET	23661758
Intra	DDIT3	P35638	CRACR2A	Homo sapiens	Q9BSW2	Validated Y2H	32296183
Intra	DDIT3	P35638	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	DDIT3	P35638	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
Intra	DDIT3	P35638	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	DDIT3	P35638	CEBPG	Homo sapiens	P53567	Anti Tag CoIP	33961781
Intra	DDIT3	P35638	HSD17B14	Homo sapiens	Q9BPX1	Validated Y2H	27107012
Intra	DDIT3	P35638	HSD17B14	Homo sapiens	Q9BPX1	Validated Y2H	32296183
Intra	DDIT3	P35638	HSD17B14	Homo sapiens	Q9BPX1	Y2H Pooling	16189514
Intra	DDIT3	P35638	BATF2	Homo sapiens	Q8N1L9	FRET	23661758
Intra	DDIT3	P35638	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	DDIT3	P35638	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	DDIT3	P35638	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	DDIT3	P35638	BATF	Homo sapiens	Q16520	Y2H	18330356
Intra	DDIT3	P35638	BATF	Homo sapiens	Q16520	Y2H Pooling	16189514
Intra	DDIT3	P35638	BATF	Homo sapiens	Q16520	FRET	23661758
Intra	DDIT3	P35638	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781
Intra	DDIT3	P35638	CEBPD	Homo sapiens	P49716	Peptide Array	20102225
Intra	DDIT3	P35638	FOS	Homo sapiens	P01100	SLC	31467278
Intra	DDIT3	P35638	FOS	Homo sapiens	P01100	Lumier	32814053
Intra	DDIT3	P35638	FOS	Homo sapiens	P01100	Lumier	37398436
Intra	DDIT3	P35638	FOS	Homo sapiens	P01100	Peptide Array	20102225
Intra	DDIT3	P35638	FOS	Homo sapiens	P01100	BRET	29997244
Intra	DDIT3	P35638	MCMBP	Homo sapiens	Q9BTE3-2	Validated Y2H	32296183
Intra	DDIT3	P35638	CEBPB	Homo sapiens	P17676	Anti Tag CoIP	33961781
Intra	DDIT3	P35638	CEBPB	Homo sapiens	P17676	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

DDIT3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81233	DDIT3 Antibody (YA3507)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P81233A	DDIT3 Antibody (YA3507)(PBS only)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P89393	DDIT3 Antibody (YA8849)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
HY-P89394	DDIT3 Antibody (YA8849)(PBS only)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Liposarcoma	Lipomatous Cancer
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Histiocytoma, Malignant Fibrous Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Fibrous, Malignant
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Pleomorphic Liposarcoma	Pls Liposarcoma Pleomorphic Liposarcoma, Pleomorphic
Cellular Myxoid Liposarcoma	Round Cell Liposarcoma
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Childhood Liposarcoma	Pediatric Liposarcoma
Myxoid Liposarcoma Of The Ovary	Myxoid Liposarcoma Of Ovary
Liposarcoma Of The Ovary	Liposarcoma Of Ovary
Open-Angle Glaucoma	Glaucoma Simplex Pigmentary Glaucoma Wide-Angle Glaucoma Glaucoma, Open-Angle Open Angle Glaucoma Glaucoma Open-Angle Chronic Simple Glaucoma Coag - [Chronic Open-Angle Glaucoma] Csg - [Chronic Simple Glaucoma] Poag - [Primary Open-Angle Glaucoma] Oag - [Open-Angle Glaucoma] Chronic Glaucoma Chronic Open Angle Glaucoma Simple Glaucoma Chronic Noncongestive Glaucoma Ltg - [Low Tension Glaucoma] Noncongestive Glaucoma Nonobstructive Glaucoma Normal Pressure Glaucoma Primary Low Tension Glaucoma Low-Tension Glaucoma Residual Stage Low Tension Glaucoma Open Cleft Glaucoma
Pancreas Sarcoma	Sarcoma Of Pancreas
Spindle Cell Lipoma
Pleomorphic Lipoma	Lipoma Lipoma Pleomorphic Lipomatosis, Multiple
Myxofibrosarcoma	Fibromyxosarcoma Fibromyxoid Sarcoma Myxoid Malignant Fibrous Histiocytoma Dermatofibrosarcoma Protuberans, Myxoid
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus	Wolcott-Rallison Syndrome Med-Iddm Syndrome Iddm-Med Syndrome Wolcott Rallison Syndrome WRS Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Diabetes Mellitus	Diabetes
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03614	DDIT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183004	NCP26		/	Unkown
HY-RS18059	Ddit3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24534	Ddit3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DDIT3	MGD	MGI:109247
Rattus norvegicus	DDIT3	RGD	RGD:62391
Canis familiaris	DDIT3	VGNC	VGNC:39836
Felis catus	DDIT3	VGNC	VGNC:61389
Macaca mulatta	DDIT3	VGNC	VGNC:71756
Bos taurus	DDIT3	VGNC	VGNC:27947
Others	DDIT3	NCBI