BATF2 - basic leucine zipper ATF-like transcription factor 2 Gene

Also Known as SARI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116071

About BATF2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,987,945-64,996,971 (from NCBI)

This gene has 5 transcripts (splice variants), 238 orthologues and 8 paralogues. Broad expression in spleen (RPKM 7.0), appendix (RPKM 4.9) and 23 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

BATF2 Products (3)

mRNA Protein Name
NM_001300807.2 NP_001287736.1 basic leucine zipper transcriptional factor ATF-like 2 isoform 2
NM_001300808.2 NP_001287737.1 basic leucine zipper transcriptional factor ATF-like 2 isoform 3
NM_138456.4 NP_612465.3 basic leucine zipper transcriptional factor ATF-like 2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
23661758 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BATF2 Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (16 - 69)

  • 0
  • 100
  • 200
  • 274 a.a.
Protein Preferred Names Protein Names

basic leucine zipper transcriptional factor ATF-like 2

  • B-ATF-2

BATF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BATF2 Q8N1L9 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
BATF2 Q8N1L9 YTHDF1 Homo sapiens Q9BYJ9
Validated Y2H
32296183
Intra
BATF2 Q8N1L9 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
BATF2 Q8N1L9 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
32296183
Intra
BATF2 Q8N1L9 PPP1R16A Homo sapiens Q96I34
Validated Y2H
32296183
Intra
BATF2 Q8N1L9 MAFF Homo sapiens Q9ULX9
FRET
23661758
Intra
BATF2 Q8N1L9 DAZAP2 Homo sapiens Q15038
Y2H Array
19060904
Intra
BATF2 Q8N1L9 DAZAP2 Homo sapiens Q15038
Y2H Pooling
19060904
Intra
BATF2 Q8N1L9 CEBPG Homo sapiens P53567
FRET
23661758
Intra
BATF2 Q8N1L9 DDIT3 Homo sapiens P35638
FRET
23661758
Intra
BATF2 Q8N1L9 JUNB Homo sapiens P17275
Anti Tag CoIP
21988832
Intra
BATF2 Q8N1L9 JUN Homo sapiens P05412
FRET
23661758
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01372 BATF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20369 Batf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26879 Batf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris BATF2 VGNC VGNC:38386
Felis catus BATF2 VGNC VGNC:60074
Macaca mulatta BATF2 VGNC VGNC:70127
Bos taurus BATF2 VGNC VGNC:26426
Rattus norvegicus BATF2 RGD RGD:1311481
Mus musculus BATF2 MGD MGI:1921731
Others BATF2 NCBI