JUNB - JunB proto-oncogene, AP-1 transcription factor subunit Gene

Also Known as AP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3726

About JUNB

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,791,486-12,793,315 (from NCBI)

This gene has 1 transcript (splice variant), 236 orthologues and 2 paralogues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor AP-1 complex. Biomarker of Hodgkin's lymphoma and anaplastic large cell lymphoma. [provided by Alliance of Genome Resources, Apr 2022]

JUNB Products (1)

mRNA	Protein	Name
NM_002229.3	NP_002220.1	transcription factor JunB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10508860	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
part of transcription factor AP-1 complex	IDA IDA: Inferred from direct assay	10508860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JUNB Protein Structure

Jun

bZIP_1

0
100
200
300
347 a.a.

Protein Preferred Names	Protein Names
transcription factor JunB	activator protein 1 jun B proto-oncogene transcription factor AP-1 subunit JunB transcription factor jun-B

JUNB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JUNB	P17275	FOS	Homo sapiens	Q6FG41	Y2H Prey Pooling	25416956
Intra	JUNB	P17275	BATF3	Homo sapiens	Q9NR55	Y2H Array	20211142
Intra	JUNB	P17275	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	JUNB	P17275	BATF3	Homo sapiens	Q9NR55	Peptide Array	20102225
Intra	JUNB	P17275	BATF3	Homo sapiens	Q9NR55	Anti Tag CoIP	35271311
Intra	JUNB	P17275	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
Intra	JUNB	P17275	ATF2	Homo sapiens	P15336	Peptide Array	20102225
Intra	JUNB	P17275	ATF2	Homo sapiens	P15336	Anti Tag CoIP	28514442
Intra	JUNB	P17275	JDP2	Homo sapiens	Q8WYK2	Y2H Array	20211142
Intra	JUNB	P17275	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	JUNB	P17275	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	JUNB	P17275	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	JUNB	P17275	FOSB	Homo sapiens	P53539	Y2H Prey Pooling	32296183
Intra	JUNB	P17275	FOSB	Homo sapiens	P53539	Validated Y2H	32296183
Intra	JUNB	P17275	FOSB	Homo sapiens	P53539	Y2H Array	32296183
Intra	JUNB	P17275	FOSB	Homo sapiens	P53539	Anti Tag CoIP	33961781
Intra	JUNB	P17275	FOSB	Homo sapiens	P53539	Anti Tag CoIP	28514442
Intra	JUNB	P17275	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	JUNB	P17275	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	JUNB	P17275	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	JUNB	P17275	FOSL2	Homo sapiens	P15408	Anti Tag CoIP	33961781
Intra	JUNB	P17275	FOSL2	Homo sapiens	P15408	Anti Tag CoIP	28514442
Intra	JUNB	P17275	FOSL2	Homo sapiens	P15408	Y2H Prey Pooling	32296183
Intra	JUNB	P17275	FOSL2	Homo sapiens	P15408	Peptide Array	20102225
Intra	JUNB	P17275	FOSL2	Homo sapiens	P15408	Y2H Array	32296183
Intra	JUNB	P17275	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	JUNB	P17275	ATF3	Homo sapiens	P18847	Peptide Array	20102225
Intra	JUNB	P17275	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	JUNB	P17275	ATF3	Homo sapiens	P18847	Anti Tag CoIP	33961781
Intra	JUNB	P17275	ATF3	Homo sapiens	P18847	Anti Tag CoIP	28514442
Intra	JUNB	P17275	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	JUNB	P17275	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	JUNB	P17275	BATF2	Homo sapiens	Q8N1L9	FRET	23661758
Intra	JUNB	P17275	BATF2	Homo sapiens	Q8N1L9	Y2H Array	21988832
Intra	JUNB	P17275	BATF2	Homo sapiens	Q8N1L9	Confocal	21988832
Intra	JUNB	P17275	FOSL1	Homo sapiens	P15407	Y2H Prey Pooling	32296183
Intra	JUNB	P17275	FOSL1	Homo sapiens	P15407	Y2H Pooling	16189514
Intra	JUNB	P17275	FOSL1	Homo sapiens	P15407	FRET	23661758
Intra	JUNB	P17275	FOSL1	Homo sapiens	P15407	Y2H Array	32296183
Intra	JUNB	P17275	FOSL1	Homo sapiens	P15407	Anti Tag CoIP	33961781
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	Y2H Array	25416956
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	FRET	23661758
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	Y2H Prey Pooling	25416956
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	SLC	31467278
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	Lumier	29997244
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	Y2H Array	31467278
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	Y2H Pooling	18692475
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	Peptide Array	20102225
Intra	JUNB	P17275	BATF	Homo sapiens	Q16520	BRET	29997244
Intra	JUNB	P17275	TCL1A	Homo sapiens	P56279	Anti Bait CoIP	19064921
Intra	JUNB	P17275	TCL1A	Homo sapiens	P56279	Anti Tag CoIP	19064921
Intra	JUNB	P17275	ATF7	Homo sapiens	P17544	Peptide Array	20102225
Intra	JUNB	P17275	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781
Intra	JUNB	P17275	FOS	Homo sapiens	P01100	Complementation	16511568
Intra	JUNB	P17275	FOS	Homo sapiens	P01100	FRET	23661758
Intra	JUNB	P17275	FOS	Homo sapiens	P01100	Display Tech	20195357
Intra	JUNB	P17275	FOS	Homo sapiens	P01100	Peptide Array	20102225
Cross	JUNB	P17275	MDV005	Gallid herpesvirus 2	Q9DGW5	Peptide Array	20102225
Cross	JUNB	P17275	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

JUNB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80200	JunB Antibody (YA325)	WB, ICC/IF, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Breast Scirrhous Carcinoma	Infiltrating Carcinoma Of Breast With Fibrotic Stroma Scirrhous Carcinoma Of Breast
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W011927	4,4'-Sulfonyldiphenol		99.81%	Unkown
HY-W011927S	4,4'-Sulfonyldiphenol-d8		99.21%	Unkown
HY-RS07058	Junb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07057	JUNB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07059	Junb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12025	RNASEH2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W092110	Phe-Tyr	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JUNB	VGNC	VGNC:73959
Rattus norvegicus	JUNB	RGD	RGD:2944
Felis catus	JUNB	VGNC	VGNC:67882
Mus musculus	JUNB	MGD	MGI:96647
Canis familiaris	JUNB	VGNC	VGNC:42198
Bos taurus	JUNB	VGNC	VGNC:30387
Others	JUNB	NCBI