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BATF - basic leucine zipper ATF-like transcription factor Gene

Also Known as SFA2; B-ATF; BATF1; SFA-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10538

About BATF

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,522,469-75,546,992 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 8 paralogues. Broad expression in lymph node (RPKM 11.0), appendix (RPKM 9.8) and 14 other tissues.

Summary

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

BATF Products (1)

mRNA	Protein	Name
NM_006399.5	NP_006390.1	basic leucine zipper transcriptional factor ATF-like

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8954125	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BATF Protein Structure

bZIP_1

0
100
125 a.a.

Protein Preferred Names	Protein Names
basic leucine zipper transcriptional factor ATF-like	B-cell-activating transcription factor

BATF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BATF	Q16520	ATF2	Homo sapiens	P15336	FRET	23661758
Intra	BATF	Q16520	CEBPA	Homo sapiens	P49715	Peptide Array	20102225
Intra	BATF	Q16520	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	BATF	Q16520	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	BATF	Q16520	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	BATF	Q16520	JUND	Homo sapiens	P17535	Peptide Array	20102225
Intra	BATF	Q16520	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	BATF	Q16520	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	BATF	Q16520	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	BATF	Q16520	GOPC	Homo sapiens	Q9HD26	Y2H Array	25416956
Intra	BATF	Q16520	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	BATF	Q16520	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	BATF	Q16520	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	BATF	Q16520	DBP	Homo sapiens	Q10586	FRET	23661758
Intra	BATF	Q16520	ATF4	Homo sapiens	P18848	Peptide Array	20102225
Intra	BATF	Q16520	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	BATF	Q16520	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	BATF	Q16520	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	BATF	Q16520	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	BATF	Q16520	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	BATF	Q16520	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	BATF	Q16520	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	BATF	Q16520	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	BATF	Q16520	GARS1	Homo sapiens	P41250	Y2H Pooling	32814053
Intra	BATF	Q16520	GARS1	Homo sapiens	P41250	Validated Y2H	32814053
Intra	BATF	Q16520	GARS1	Homo sapiens	P41250	Y2H Array	32814053
Intra	BATF	Q16520	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	BATF	Q16520	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
Intra	BATF	Q16520	DDIT3	Homo sapiens	P35638	Validated Y2H	27107012
Intra	BATF	Q16520	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	BATF	Q16520	DDIT3	Homo sapiens	P35638	BFG-2H	27107012
Intra	BATF	Q16520	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	BATF	Q16520	JUNB	Homo sapiens	P17275	Y2H Array	18692475
Intra	BATF	Q16520	JUNB	Homo sapiens	P17275	Lumier	37398436
Intra	BATF	Q16520	JUNB	Homo sapiens	P17275	Peptide Array	20102225
Intra	BATF	Q16520	JUNB	Homo sapiens	P17275	BRET	37398436
Intra	BATF	Q16520	JUNB	Homo sapiens	P17275	Validated Y2H	25416956
Intra	BATF	Q16520	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	BATF	Q16520	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	BATF	Q16520	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	BATF	Q16520	JUN	Homo sapiens	P05412	Peptide Array	20102225
Intra	BATF	Q16520	JUN	Homo sapiens	P05412	FRET	23661758
Intra	BATF	Q16520	CEBPB	Homo sapiens	P17676	Peptide Array	20102225
Intra	BATF	Q16520	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	BATF	Q16520	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	BATF	Q16520	PEX1	Homo sapiens	O43933	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01372	BATF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19308	Batf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01371	BATF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01373	BATF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20369	Batf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21496	Batf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25799	Batf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26879	Batf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28014	Batf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BATF	VGNC	VGNC:70229
Rattus norvegicus	BATF	RGD	RGD:1304923
Bos taurus	BATF	VGNC	VGNC:26425
Felis catus	BATF	VGNC	VGNC:81030
Canis familiaris	BATF	VGNC	VGNC:38385
Mus musculus	BATF	MGD	MGI:1859147
Others	BATF	NCBI