DBP - D-box binding PAR bZIP transcription factor Gene

Also Known as DABP; taxREB302

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1628

About DBP

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,630,030-48,637,379 (from NCBI)

This gene has 5 transcripts (splice variants), 251 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 6.3), spleen (RPKM 6.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

DBP Products (1)

mRNA Protein Name
NM_001352.5 NP_001343.2 D site-binding protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20093779 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20093779 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20093779 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
23661758 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBP Protein Structure

bZIP_2

bZIP_2: Basic region leucine zipper (254 - 307)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

D site-binding protein

  • D site of albumin promoter (albumin D-box) binding protein

DBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DBP Q10586 BATF3 Homo sapiens Q9NR55
FRET
23661758
Intra
DBP Q10586 HLF Homo sapiens Q16534
FRET
23661758
Intra
DBP Q10586 DDIT3 Homo sapiens P35638
Y2H
21988832
Intra
DBP Q10586 DDIT3 Homo sapiens P35638
FRET
23661758
Intra
DBP Q10586 BATF Homo sapiens Q16520
FRET
23661758
Cross: Cross-species interaction Intra: Intraspecies interaction

DBP Antibodies

Cat. No. Product Name Application Reactivity
HY-P810252 DABP Antibody (YA9596) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Hemophilia B

  • Christmas Disease

  • Factor Ix Deficiency

  • F9 Deficiency

  • HEMB

  • Plasma Thromboplastin Component Deficiency

  • Congenital Factor Ix Deficiency

  • Mild Hemophilia B

  • Severe Hemophilia B

  • Congenital Factor Ix Disorder

  • Deficiency, Functional Factor Ix

  • Hem B

  • Mild Congenital F9 Deficiency

  • Mild Congenital Factor Ix Deficiency

  • Moderate Hemophilia B

  • Moderate Congenital F9 Deficiency

  • Moderate Congenital Factor Ix Deficiency

  • Severe Congenital F9 Deficiency

  • Severe Congenital Factor Ix Deficiency

  • Bleeding Disorder In Hemophilia B Carriers

  • Congenital F9 Deficiency

  • Recessive X-Linked Hemophilia B
Delayed Sleep Phase Disorder

  • Delayed Sleep Phase Syndrome

  • Delayed Sleep Phase Syndrome, Susceptibility To

  • DSPD

  • Delayed Sleep Phase Disorder, Susceptibility To

  • DSPS

  • Sleep Phase, Delayed, Disorder

  • Sleep Phase Syndrome, Delayed, Susceptibility To
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y0678 1,3,5-Trimethoxybenzene 99.96% Unkown
HY-Y1667 2,6-Dibromophenol Inhibitor 99.76% Unkown
HY-N7143 Monobutyl phthalate 99.72% Unkown
HY-N7143S Monobutyl phthalate-d4 99.33% Unkown
HY-133631 Chloronitromethane 98.12% Unkown
HY-133630 1-Bromo-1,1-dichloroacetone / Unkown
HY-133625 1,1-Dibromo-3-chloroacetone / Unkown
HY-133626 1,1-Dibromo-3,3-dichloroacetone / Unkown
HY-133627 1,3-Dibromo-1,3-dichloroacetone / Unkown
HY-133628 1,1,3-Tribromo-3-chloroacetone / Unkown
HY-133633 Bromodichloronitromethane / Unkown
HY-133635 Tribromonitromethane / Unkown
HY-133636 Bromochloronitromethane / Unkown
HY-133656 (Z)-2-Bromo-3-methyl-2-butenedioic acid / Unkown
HY-133659 Diiodoacetic acid / Unkown
HY-133664 Dibromochloroacetamide / Unkown
HY-133665 2,2-Dibromoacetamide / Unkown
HY-RS03552 DBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05316 GC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06397 HSD17B4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-133629 1,1,1,3-Tetrachloroacetone / Unkown
HY-133634 Dibromochloronitromethane / Unkown
HY-133655 (E)-2,3-Dibromo-2-butenedioic acid / Unkown
HY-133657 Bromoiodoacetic acid / Unkown
HY-133666 Diiodoacetamide / Unkown
HY-180503 19-Nor-22-oxa-1a,25(OH)2-VD3 / Unkown
HY-RS16765 Gc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17285 Dbp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20632 Hsd17b4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23205 Gc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23740 Dbp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27763 Mybbp1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W243879 Tetraphenyldibenzoperiflanthene / Unkown
HY-W704657 Monobutyl phosphate-d9 / Unkown
HY-Y0678R 1,3,5-Trimethoxybenzene (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DBP VGNC VGNC:39785
Macaca mulatta DBP VGNC VGNC:71743
Bos taurus DBP VGNC VGNC:27894
Rattus norvegicus DBP RGD RGD:2491
Mus musculus DBP MGD MGI:94866
Others DBP NCBI