CEBPB - CCAAT enhancer binding protein beta Gene

Also Known as TCF5; IL6DBP; NF-IL6; C/EBP-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1051

About CEBPB

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,190,583-50,192,690 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 4 paralogues.

Summary

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among Other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]

CEBPB Products (3)

mRNA	Protein	Name
NM_001285878.1	NP_001272807.1	CCAAT/enhancer-binding protein beta isoform b
NM_001285879.1	NP_001272808.1	CCAAT/enhancer-binding protein beta isoform c
NM_005194.4	NP_005185.2	CCAAT/enhancer-binding protein beta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7959007	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7651415	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	30355733	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	27812542	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27812542	GOA
acts upstream of or within positive regulation of biomineral tissue development	IDA IDA: Inferred from direct assay	27812542	GOA
acts upstream of or within positive regulation of biomineral tissue development	IMP IMP: Inferred from mutant phenotype	27812542	GOA
acts upstream of or within positive regulation of sodium-dependent phosphate transport	IDA IDA: Inferred from direct assay	27812542	GOA
acts upstream of or within positive regulation of sodium-dependent phosphate transport	IMP IMP: Inferred from mutant phenotype	27812542	GOA
involved in positive regulation of transcription by RNA polymerase II	EXP EXP: Inferred from Experiment	11792321	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7959007	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15775988	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20829347	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18647749	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	15775988	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of C/EBP complex	IPI IPI: Inferred from physical interaction	20102225	GOA
part of CHOP-C/EBP complex	IPI IPI: Inferred from physical interaction	20102225	GOA
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	11792321	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20829347	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEBPB Protein Structure

bZIP_2

0
100
200
300
345 a.a.

Protein Preferred Names	Protein Names
CCAAT/enhancer-binding protein beta	CCAAT/enhancer binding protein (C/EBP), beta

CEBPB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CEBPB	P17676	P15941-PRO_0000317447	Homo sapiens	P15941-PRO_0000317447	Anti Bait CoIP	24043631
Intra	CEBPB	P17676	P15941-PRO_0000317447	Homo sapiens	P15941-PRO_0000317447	Confocal	24043631
Intra	CEBPB	P17676	CEBPA	Homo sapiens	P49715	Peptide Array	20102225
Cross	CEBPB	P17676	E2	Human papillomavirus	P03120	Pull Down	12692227
Intra	CEBPB	P17676	TP53	Homo sapiens	P04637	IF	16227626
Cross	CEBPB	P17676	E2	Human papillomavirus	P06790	Anti Bait CoIP	12692227
Cross	CEBPB	P17676	E2	Human papillomavirus	P06790	Pull Down	12692227
Cross	CEBPB	P17676	E2	Bovine papillomavirus	P03122	Pull Down	12692227
Cross	CEBPB	P17676	E2	Human papillomavirus	P06422	Pull Down	12692227
Intra	CEBPB	P17676	CEBPG	Homo sapiens	P53567	Peptide Array	20102225
Intra	CEBPB	P17676	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	CEBPB	P17676	ESR1	Homo sapiens	P03372	Pull Down	7651415

Cross: Cross-species interaction Intra: Intraspecies interaction

CEBPB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80490	CEBP beta Antibody (YA576)	WB, FC, IP	Human, Rat
HY-P82090	CEBP beta Antibody (YA1835)	WB, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P85068	CEBP beta Antibody (YA4760)	WB, FC, ELISA	Human

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Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02446	CEBPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23873	Cebpb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17419	Cebpb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CEBPB	VGNC	VGNC:84575
Canis familiaris	CEBPB	VGNC	VGNC:54618
Mus musculus	CEBPB	MGD	MGI:88373
Rattus norvegicus	CEBPB	RGD	RGD:2327
Others	CEBPB	NCBI