CEBPA - CCAAT enhancer binding protein alpha Gene
Also Known as CEBP; C/EBP-alpha
Species: Homo sapiens
About CEBPA
This gene has 1 transcript (splice variant), 167 orthologues, 4 paralogues and is associated with 66 phenotypes.
Summary
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
CEBPA Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001285829.2 | NP_001272758.1 | CCAAT/enhancer-binding protein alpha isoform b |
| NM_001287424.2 | NP_001274353.1 | CCAAT/enhancer-binding protein alpha isoform c |
| NM_001287435.2 | NP_001274364.1 | CCAAT/enhancer-binding protein alpha isoform d |
| NM_004364.5 | NP_004355.2 | CCAAT/enhancer-binding protein alpha isoform a |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of C/EBP complex |
IPI
IPI: Inferred from physical interaction
|
20102225 | GOA |
| part of CHOP-C/EBP complex |
IPI
IPI: Inferred from physical interaction
|
20102225 | GOA |
| part of RNA polymerase II transcription regulator complex |
IMP
IMP: Inferred from mutant phenotype
|
16946298 | GOA |
| part of RNA polymerase II transcription regulator complex |
IPI
IPI: Inferred from physical interaction
|
20102225 | GOA |
| located in nucleolus |
IDA
IDA: Inferred from direct assay
|
20075868 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
11242107 | GOA |
| part of transcription regulator complex |
IDA
IDA: Inferred from direct assay
|
24429361 | GOA |
CEBPA Protein Structure
bZIP_2: Basic region leucine zipper (282 - 334)
- 0
- 100
- 200
- 300
- 358 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
CCAAT/enhancer-binding protein alpha |
|
CEBPA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CEBPA | P49715 | BATF3 | Homo sapiens | Q9NR55 | 23661758 | |
|
Intra
|
CEBPA | P49715 | CEBPG | Homo sapiens | P53567 | 20102225 | |
|
Intra
|
CEBPA | P49715 | CEBPA | Homo sapiens | P49715 | 23661758 | |
|
Intra
|
CEBPA | P49715 | ATF5 | Homo sapiens | Q9Y2D1 | 23661758 | |
|
Cross
|
CEBPA | P49715 | E2 | Human papillomavirus | P06422 | 12692227 | |
|
Intra
|
CEBPA | P49715 | CEBPA | Homo sapiens | P49715 | 20102225 | |
|
Intra
|
CEBPA | P49715 | DDIT3 | Homo sapiens | P35638 | 20102225 | |
|
Intra
|
CEBPA | P49715 | ATF4 | Homo sapiens | P18848 | 23661758 | |
|
Intra
|
CEBPA | P49715 | DDIT3 | Homo sapiens | P35638 | 23661758 | |
|
Intra
|
CEBPA | P49715 | CEBPG | Homo sapiens | P53567 | 23661758 | |
|
Intra
|
CEBPA | P49715 | BATF | Homo sapiens | Q16520 | 23661758 | |
|
Intra
|
CEBPA | P49715 | PARP1 | Homo sapiens | P09874 | 16490787 | |
|
Intra
|
CEBPA | P49715 | CEBPE | Homo sapiens | Q15744 | 23661758 | |
|
Cross
|
CEBPA | P49715 | E2 | Bovine papillomavirus | P03122 | 12692227 | |
|
Intra
|
CEBPA | P49715 | ATF3 | Homo sapiens | P18847 | 23661758 | |
|
Intra
|
CEBPA | P49715 | BATF2 | Homo sapiens | Q8N1L9 | 23661758 | |
|
Intra
|
CEBPA | P49715 | CEBPD | Homo sapiens | P49716 | 20102225 | |
|
Intra
|
CEBPA | P49715 | CDX1 | Homo sapiens | P47902 | 19059241 | |
|
Intra
|
CEBPA | P49715 | CDX1 | Homo sapiens | P47902 | 19059241 | |
|
Intra
|
CEBPA | P49715 | FOS | Homo sapiens | P01100 | 23661758 | |
|
Intra
|
CEBPA | P49715 | IL32 | Homo sapiens | P24001-2 | 23814099 | |
|
Intra
|
CEBPA | P49715 | IL32 | Homo sapiens | P24001-2 | 23814099 | |
|
Intra
|
CEBPA | P49715 | CEBPB | Homo sapiens | P17676 | 20102225 |
CEBPA Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81161 | CEBP-alpha Antibody | WB, ELISA, IHC-P, IHC-F, FC, ICC/IF | Human, Rat |
| HY-P86181 | CEBP-alpha Antibody (YA5873) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Leukemia, Acute Myeloid |
|
|
| Acute Myeloid Leukemia With T(8;21)(Q22;Q22) Translocation |
|
|
| Acute Leukemia |
|
|
| Leukemia |
|
|
| Myeloid Leukemia |
|
|
| Severe Congenital Neutropenia |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Bap1 Tumor Predisposition Syndrome |
|
|
| Familial Partial Lipodystrophy |
|
|
| Actinomycosis |
|
|
| Liposarcoma |
|
|
| Core Binding Factor Acute Myeloid Leukemia |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Pulmonary Immaturity |
|
|
| Childhood Acute Myeloid Leukemia |
|
|
| Microphthalmia, Isolated 1 |
|
|
| Immunodeficiency 21 |
|
|
| Adenoid Cystic Carcinoma |
|
|
| Hepatoblastoma |
|
|
| Diamond-Blackfan Anemia 11 |
|
|
| Childhood Leukemia |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Acute Erythroid Leukemia |
|
|
| Osteoporosis |
|
|
| Chronic Myelomonocytic Leukemia |
|
|
| Overnutrition |
|
|
| Acquired Metabolic Disease |
|
|
| Acute Megakaryocytic Leukemia |
|
|
| Congenital Generalized Lipodystrophy |
|
|
| Shwachman-Diamond Syndrome 1 |
|
|
| Myelodysplastic Syndrome |
|
|
| Dyskeratosis Congenita |
|
|
| Diamond-Blackfan Anemia |
|
|
| Type 2 Diabetes Mellitus |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CEBPA | MGD | MGI:99480 |
| Rattus norvegicus | CEBPA | RGD | RGD:2326 |
| Macaca mulatta | CEBPA | VGNC | VGNC:71000 |
| Others | CEBPA | NCBI |