ATF5 - activating transcription factor 5 Gene

Also Known as ATFX; HMFN0395

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22809

About ATF5

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,928,906-49,933,935 (from NCBI)

This gene has 5 transcripts (splice variants), 234 orthologues and 1 paralogue. Biased expression in liver (RPKM 197.1), thyroid (RPKM 55.7) and 2 other tissues.

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and tubulin binding activity. Involved in several processes, including fat cell differentiation; regulation of cell cycle process; and regulation of transcription, DNA-templated. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ATF5 Products (3)

mRNA	Protein	Name
NM_001193646.2	NP_001180575.1	cyclic AMP-dependent transcription factor ATF-5
NM_001290746.2	NP_001277675.1	cyclic AMP-dependent transcription factor ATF-5
NM_012068.6	NP_036200.2	cyclic AMP-dependent transcription factor ATF-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16300731	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20654631	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	15890932	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	21212266	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	25512613	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10373550	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	26213385	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	24216764	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22528486	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21212266	GOA
involved in negative regulation of cell cycle G2/M phase transition	IDA IDA: Inferred from direct assay	22528486	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	22528486	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21212266	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16300731	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20654631	GOA
involved in regulation of centrosome cycle	IDA IDA: Inferred from direct assay	26213385	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
located in centrosome	IDA IDA: Inferred from direct assay	26213385	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22528486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF5 Protein Structure

bZIP_1

0
100
200
282 a.a.

Protein Preferred Names	Protein Names
cyclic AMP-dependent transcription factor ATF-5	cAMP-dependent transcription factor ATF-5

ATF5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATF5	Q9Y2D1	CEBPA	Homo sapiens	P49715	Peptide Array	20102225
Intra	ATF5	Q9Y2D1	DISC1	Homo sapiens	Q9NRI5	Y2H	12812986
Intra	ATF5	Q9Y2D1	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	ATF5	Q9Y2D1	CEBPG	Homo sapiens	P53567	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

ATF5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82439	ATF5 Antibody (YA2184)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P82439A	ATF5 Antibody (YA2184)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cardiomyopathy, Familial Hypertrophic, 15	Hypertrophic Cardiomyopathy 15 CMH15 Cardiomyopathy, Hypertrophic, 15 Cardiomyopathy Familial Hypertrophic 15 Cardiomyopathy, Familial Hypertrophic 15 Cardiomyopathy, Hypertrophic, Familial, Type 15
Triple-Receptor Negative Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112680A	Carboxy pyridostatin trifluoroacetate salt		99.49%	Unkown
HY-112680	Carboxypyridostatin		99.41%	Unkown
HY-RS19118	Atf5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01131	ATF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25608	Atf5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATF5	VGNC	VGNC:38211
Rattus norvegicus	ATF5	RGD	RGD:628902
Macaca mulatta	ATF5	VGNC	VGNC:108472
Bos taurus	ATF5	VGNC	VGNC:26243
Mus musculus	ATF5	MGD	MGI:2141857
Others	ATF5	NCBI