ATF5 - activating transcription factor 5 Gene

Homo sapiens

Also known as ATFX; HMFN0395

Gene ID: 22809 | Gene type: protein coding

About ATF5

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,928,906-49,933,935 (from NCBI)

This gene has 5 transcripts (splice variants), 234 orthologues and 1 paralogue. Biased expression in liver (RPKM 197.1), thyroid (RPKM 55.7) and 2 other tissues.

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and tubulin binding activity. Involved in several processes, including fat cell differentiation; regulation of cell cycle process; and regulation of transcription, DNA-templated. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ATF5 Products(3)

mRNA	Protein	Name
NM_001193646.2	NP_001180575.1	cyclic AMP-dependent transcription factor ATF-5
NM_001290746.2	NP_001277675.1	cyclic AMP-dependent transcription factor ATF-5
NM_012068.6	NP_036200.2	cyclic AMP-dependent transcription factor ATF-5

ATF5 Protein Structure

bZIP_1

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-dependent transcription factor ATF-5

cAMP-dependent transcription factor ATF-5

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 15

Hypertrophic Cardiomyopathy 15	CMH15
Cardiomyopathy, Hypertrophic, 15	Cardiomyopathy Familial Hypertrophic 15
Cardiomyopathy, Familial Hypertrophic 15	Cardiomyopathy, Hypertrophic, Familial, Type 15

Triple-Receptor Negative Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01131	ATF5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATF5	VGNC	VGNC:38211
Rattus norvegicus	ATF5	RGD	RGD:628902
Macaca mulatta	ATF5	VGNC	VGNC:108472
Bos taurus	ATF5	VGNC	VGNC:26243
Mus musculus	ATF5	MGD	MGI:2141857