DISC1 - DISC1 scaffold protein Gene

Also Known as SCZD9; C1orf136

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27185

About DISC1

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:231,626,790-232,041,272 (from NCBI)

This gene has 23 transcripts (splice variants), 194 orthologues and is associated with 2 phenotypes. Ubiquitous expression in placenta (RPKM 2.1), ovary (RPKM 1.4) and 24 other tissues.

Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with Other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

DISC1 Products (23)

mRNA	Protein	Name
NM_001012957.2	NP_001012975.1	disrupted in schizophrenia 1 protein isoform Lv
NM_001012958.2	NP_001012976.1	disrupted in schizophrenia 1 protein isoform Es
NM_001012959.2	NP_001012977.1	disrupted in schizophrenia 1 protein isoform S
NM_001164537.2	NP_001158009.1	disrupted in schizophrenia 1 protein isoform a
NM_001164538.2	NP_001158010.1	disrupted in schizophrenia 1 protein isoform b
NM_001164539.2	NP_001158011.1	disrupted in schizophrenia 1 protein isoform c
NM_001164540.2	NP_001158012.1	disrupted in schizophrenia 1 protein isoform d
NM_001164541.2	NP_001158013.1	disrupted in schizophrenia 1 protein isoform e
NM_001164542.2	NP_001158014.1	disrupted in schizophrenia 1 protein isoform f
NM_001164544.2	NP_001158016.1	disrupted in schizophrenia 1 protein isoform g
NM_001164545.2	NP_001158017.1	disrupted in schizophrenia 1 protein isoform h
NM_001164546.2	NP_001158018.1	disrupted in schizophrenia 1 protein isoform i
NM_001164547.2	NP_001158019.1	disrupted in schizophrenia 1 protein isoform i
NM_001164548.2	NP_001158020.1	disrupted in schizophrenia 1 protein isoform k
NM_001164549.2	NP_001158021.1	disrupted in schizophrenia 1 protein isoform l
NM_001164550.2	NP_001158022.1	disrupted in schizophrenia 1 protein isoform m
NM_001164551.2	NP_001158023.1	disrupted in schizophrenia 1 protein isoform n
NM_001164552.2	NP_001158024.1	disrupted in schizophrenia 1 protein isoform o
NM_001164553.2	NP_001158025.1	disrupted in schizophrenia 1 protein isoform p
NM_001164554.2	NP_001158026.1	disrupted in schizophrenia 1 protein isoform q
NM_001164555.2	NP_001158027.1	disrupted in schizophrenia 1 protein isoform r
NM_001164556.2	NP_001158028.1	disrupted in schizophrenia 1 protein isoform t
NM_018662.3	NP_061132.2	disrupted in schizophrenia 1 protein isoform L

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	30561706	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12812986	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18955030	GOA
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	19502360	GOA
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	20531939	GOA
involved in positive regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19303846	GOA
involved in positive regulation of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	19303846	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	16736468	GOA
located in centrosome	IDA IDA: Inferred from direct assay	18762586	GOA
located in ciliary base	IDA IDA: Inferred from direct assay	20531939	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16736468	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20880836	GOA
is active in postsynaptic density	IDA IDA: Inferred from direct assay	16736468	GOA
is active in presynapse	IDA IDA: Inferred from direct assay	16736468	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
disrupted in schizophrenia 1 protein

DISC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DISC1	Q9NRI5	AKAP9	Homo sapiens	Q99996	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	AKAP9	Homo sapiens	Q99996	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	TNIK	Homo sapiens	Q9UKE5	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	TNIK	Homo sapiens	Q9UKE5	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	HERC2	Homo sapiens	O95714	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	HERC2	Homo sapiens	O95714	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	CLU	Homo sapiens	P10909	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	CEP170	Homo sapiens	Q5SW79	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	CEP170	Homo sapiens	Q5SW79	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	CEP170	Homo sapiens	Q5SW79	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	KIF3A	Homo sapiens	Q9Y496	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	KIF3C	Homo sapiens	O14782	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	PDE4DIP	Homo sapiens	Q5VU43	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	PDE4DIP	Homo sapiens	Q5VU43	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	TFIP11	Homo sapiens	Q9UBB9	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	TNKS	Homo sapiens	O95271	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	TNKS	Homo sapiens	O95271	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	ANGEL1	Homo sapiens	Q9UNK9	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	ANGEL1	Homo sapiens	Q9UNK9	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	ANKHD1	Homo sapiens	Q8IWZ3-1	Y2H	12812986
Intra	DISC1	Q9NRI5	ANKHD1	Homo sapiens	Q8IWZ3-1	Anti Tag CoIP	12812986
Intra	DISC1	Q9NRI5	MAP4K4	Homo sapiens	O95819	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	RGPD5	Homo sapiens	Q99666	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	RGPD5	Homo sapiens	Q99666	Y2H Fragment Pooling	31413325
Cross	DISC1	Q9NRI5	Mad2l1	Mus musculus	Q9Z1B5	Pull Down	29961565
Cross	DISC1	Q9NRI5	Cep170	Mus musculus	Q6A065	Pull Down	29961565
Intra	DISC1	Q9NRI5	DRD2	Homo sapiens	P14416	Anti Tag CoIP	32493513
Intra	DISC1	Q9NRI5	NUP160	Homo sapiens	Q12769	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	NAV1	Homo sapiens	Q8NEY1	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	NAV1	Homo sapiens	Q8NEY1	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	SPTBN4	Homo sapiens	Q9H254	Y2H	12812986
Intra	DISC1	Q9NRI5	ALMS1	Homo sapiens	Q8TCU4	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	ALMS1	Homo sapiens	Q8TCU4	Anti Tag CoIP	33961781
Cross	DISC1	Q9NRI5	Nde1	Mus musculus	Q9CZA6	Pull Down	29961565
Intra	DISC1	Q9NRI5	DST	Homo sapiens	Q03001	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	DST	Homo sapiens	Q03001	Y2H	17043677
Intra	DISC1	Q9NRI5	YWHAZ	Homo sapiens	P63104	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	SPTAN1	Homo sapiens	Q13813	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	SPTAN1	Homo sapiens	Q13813	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	GSN	Homo sapiens	P06396	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	SPTBN1	Homo sapiens	Q01082	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	SPTBN1	Homo sapiens	Q01082	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	MATR3	Homo sapiens	P43243	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	MATR3	Homo sapiens	P43243	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	DYNC1H1	Homo sapiens	Q14204	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	YWHAE	Homo sapiens	P62258	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	DNAJC7	Homo sapiens	Q99615	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	XRN2	Homo sapiens	Q9H0D6	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	XRN2	Homo sapiens	Q9H0D6	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	NUP210	Homo sapiens	Q8TEM1	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	SPAG5	Homo sapiens	Q96R06	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	SPAG5	Homo sapiens	Q96R06	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	TNKS2	Homo sapiens	Q9H2K2	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	IMMT	Homo sapiens	Q16891	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	ATF4	Homo sapiens	P18848	Y2H	12812986
Intra	DISC1	Q9NRI5	ATF4	Homo sapiens	P18848	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	ATF5	Homo sapiens	Q9Y2D1	IF	12812986
Intra	DISC1	Q9NRI5	ATF5	Homo sapiens	Q9Y2D1	Y2H	12812986
Intra	DISC1	Q9NRI5	ATF5	Homo sapiens	Q9Y2D1	Anti Tag CoIP	12812986
Intra	DISC1	Q9NRI5	MACF1	Homo sapiens	Q9UPN3	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Y2H	12812986
Intra	DISC1	Q9NRI5	TRAF3IP1	Homo sapiens	Q8TDR0	IF	12812986
Intra	DISC1	Q9NRI5	TRAF3IP1	Homo sapiens	Q8TDR0	Y2H	12812986
Intra	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	TRAF3IP1	Homo sapiens	Q8TDR0	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	IF	12812986
Intra	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Anti Tag CoIP	12812986
Intra	DISC1	Q9NRI5	TRAF3IP1	Homo sapiens	Q8TDR0	Anti Tag CoIP	12812986
Intra	DISC1	Q9NRI5	PCNT	Homo sapiens	O95613	Anti Tag CoIP	15094396
Intra	DISC1	Q9NRI5	PCNT	Homo sapiens	O95613	Cosedimentation	12812986
Intra	DISC1	Q9NRI5	PCNT	Homo sapiens	O95613	Y2H	15094396
Intra	DISC1	Q9NRI5	ITSN1	Homo sapiens	Q15811	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	RANBP9	Homo sapiens	Q96S59	Y2H	12812986
Intra	DISC1	Q9NRI5	RANBP9	Homo sapiens	Q96S59	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	RANBP9	Homo sapiens	Q96S59	Anti Tag CoIP	12812986
Cross	DISC1	Q9NRI5	Ndel1	Mus musculus	Q9ERR1	Pull Down	29961565
Intra	DISC1	Q9NRI5	EIF3H	Homo sapiens	O15372	Y2H	12812986
Intra	DISC1	Q9NRI5	EIF3H	Homo sapiens	O15372	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	EIF3H	Homo sapiens	O15372	Anti Tag CoIP	12812986
Intra	DISC1	Q9NRI5	GRIPAP1	Homo sapiens	Q4V328	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	GRIPAP1	Homo sapiens	Q4V328	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	GRIPAP1	Homo sapiens	Q4V328	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	TRIO	Homo sapiens	O75962	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	TRIM27	Homo sapiens	P14373	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	TRIM27	Homo sapiens	P14373	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	PAFAH1B1	Homo sapiens	P43034	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	PAFAH1B1	Homo sapiens	P43034	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	TRIM37	Homo sapiens	O94972	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	TRIM37	Homo sapiens	O94972	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	CEP63	Homo sapiens	Q96MT8	Y2H	12812986
Intra	DISC1	Q9NRI5	CEP63	Homo sapiens	Q96MT8	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	RNF40	Homo sapiens	O75150	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	RNF40	Homo sapiens	O75150	Anti Tag CoIP	33961781
Cross	DISC1	Q9NRI5	Gripap1	Mus musculus	Q8VD04	Pull Down	29961565
Intra	DISC1	Q9NRI5	ACTN2	Homo sapiens	P35609	Y2H	12812986
Intra	DISC1	Q9NRI5	ACTN2	Homo sapiens	P35609	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	GATAD2B	Homo sapiens	Q8WXI9	Anti Tag CoIP	29961565
Intra	DISC1	Q9NRI5	GATAD2B	Homo sapiens	Q8WXI9	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	ATF7IP	Homo sapiens	Q6VMQ6	Y2H	12812986
Intra	DISC1	Q9NRI5	CCDC141	Homo sapiens	Q6ZP82	Y2H	12812986
Intra	DISC1	Q9NRI5	SYNE1	Homo sapiens	Q8NF91	Y2H	12812986
Intra	DISC1	Q9NRI5	SYNE1	Homo sapiens	Q8NF91	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	MAP1A	Homo sapiens	P78559	Anti Tag CoIP	12812986
Intra	DISC1	Q9NRI5	MAP1A	Homo sapiens	P78559	Y2H	12812986
Intra	DISC1	Q9NRI5	NDE1	Homo sapiens	Q9NXR1	Anti Tag CoIP	33961781
Intra	DISC1	Q9NRI5	NDE1	Homo sapiens	Q9NXR1	Y2H Fragment Pooling	31413325
Intra	DISC1	Q9NRI5	NDE1	Homo sapiens	Q9NXR1	Anti Tag CoIP	29961565

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Schizophrenia 9	SCZD9 Schizophrenia 9 With Or Without An Affective Disorder Schizophrenia Susceptibility Locus, Chromosome 1q42-Related Schizophrenia 9, Susceptibility To Schizophrenia Susceptibility Locus Chromosome 1q-Related Schizophrenia, Type 9
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Schizophrenia 1	SCZD1 Schizophrenia Susceptibility Locus, Chromosome 5-Related Schizophrenia 1 With Or Without An Affective Disorder
Schizoaffective Disorder	Schizo-Affective Psychosis Schizo-Affective Type Schizophrenia Schizoaffective Psychosis Schizoaffective Schizophrenia Schizophrenia, Schizo-Affective Type Schizophreniform Psychosis, Affective Type
Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Lissencephaly 1	LIS1 Classic Lissencephaly Ils Subcortical Laminar Heterotopia Lissencephaly Due To Lis1 Mutation Lissencephaly Sequence, Isolated Lissencephaly, Classic Pafah1b1-Related Lissencephaly Classical Lissencephaly Lissencephaly Type 1 Lissencephaly-1 Subcortical Band Heterotopia Double Cortex Lissencephaly Classic Lissencephaly Sequence Isolated Isolated Lissencephaly Sequence Type 1 Lissencephaly Lissencephaly Syndrome Type 1 SBH Sclh Lissencephaly, Type 1 Type I Lissencephaly
Cyclothymic Disorder	Cyclothymia Cycloid Personality Cyclothymic Personality Affective Personality Disorder Cyclothymic Personality Disorder Cycloid Personality Disorder
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Asperger Syndrome	Asperger Disorder Asperger Syndrome, Susceptibility To
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Mood Disorder	Mood Disorders Episodic Mood Disorder
Tardive Dyskinesia	Drug-Induced Tardive Dyskinesia Lingual-Facial-Buccal Dyskinesia Neuroleptic-Induced Tardive Dyskinesia
Schizophrenia 5	SCZD5 Schizophrenia Susceptibility Locus, Chromosome 6q-Related Schizophrenia 5 With Or Without An Affective Disorder
Subacute Delirium	Delirium Acute Confusional State Nos
Paranoid Schizophrenia	Chronic Paranoid Schizophrenia Paranoid Type Schizophrenia Paranoid Type Schizophrenia Subchronic State Paraphrenia - Late Paraphrenic Schizophrenia Schizophrenia, Paranoid
Schizophreniform Disorder	Schizophreniform Disorders Psychotic Disorders
Schizophrenia 2	SCZD2 Schizophrenia Susceptibility Locus, Chromosome 11q-Related Schizophrenia Susceptibility Locus Chromosome 11q-Related
Schizotypal Personality Disorder	Schizotypal Personality
Schizophrenia 18	SCZD18 Schizophrenia 18 With Or Without An Affective Disorder Schizophrenia Susceptibility 18 Chromosome 7q36.3 Duplication Syndrome, 362-Kb Schizophrenia, Type 18
Paranoid Personality Disorder
Schizoid Personality Disorder
Bardet-Biedl Syndrome 4	BBS4 Bardet-Biedl Syndrome, Type 4
Miller-Dieker Lissencephaly Syndrome	Miller-Dieker Syndrome Mds MDLS Miller Dieker Syndrome Classical Lissencephaly Syndrome Lissencephaly Due To 17p13.3 Deletion Monosomy 17p13.3 Telomeric Deletion 17p Classical Lissencephaly
Mental Depression	Depression Depressive Disorder
Cannabis Abuse	Marijuana Abuse
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Spinocerebellar Ataxia 44	SCA44
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Delusional Disorder	Persistent Delusional Disorders Delusional Perception Induced Delusional Disorder
Disease Of Mental Health	Mental Health Mental Disorders
Bipolar I Disorder	Manic Depression Nos Manic-Depressive Illness Bipolar Disorder Nos
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome
Specific Developmental Disorder
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108909	Chymopapain		/	Unkown
HY-121003	Aspyrone		/	Unkown
HY-RS03781	DISC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21555	Disc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28073	Disc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DISC1	VGNC	VGNC:106712
Felis catus	DISC1	VGNC	VGNC:82471
Canis familiaris	DISC1	VGNC	VGNC:39965
Macaca mulatta	DISC1	VGNC	VGNC:71799
Mus musculus	DISC1	MGD	MGI:2447658
Rattus norvegicus	DISC1	RGD	RGD:631359
Others	DISC1	NCBI