DISC1 - DISC1 scaffold protein Gene

Homo sapiens

Also known as SCZD9; C1orf136

Gene ID: 27185 | Gene type: protein coding

About DISC1

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:231,626,790-232,041,272 (from NCBI)

This gene has 23 transcripts (splice variants), 194 orthologues and is associated with 2 phenotypes. Ubiquitous expression in placenta (RPKM 2.1), ovary (RPKM 1.4) and 24 other tissues.

Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

DISC1 Products(23)

mRNA	Protein	Name
NM_001012957.2	NP_001012975.1	disrupted in schizophrenia 1 protein isoform Lv
NM_001012958.2	NP_001012976.1	disrupted in schizophrenia 1 protein isoform Es
NM_001012959.2	NP_001012977.1	disrupted in schizophrenia 1 protein isoform S
NM_001164537.2	NP_001158009.1	disrupted in schizophrenia 1 protein isoform a
NM_001164538.2	NP_001158010.1	disrupted in schizophrenia 1 protein isoform b
NM_001164539.2	NP_001158011.1	disrupted in schizophrenia 1 protein isoform c
NM_001164540.2	NP_001158012.1	disrupted in schizophrenia 1 protein isoform d
NM_001164541.2	NP_001158013.1	disrupted in schizophrenia 1 protein isoform e
NM_001164542.2	NP_001158014.1	disrupted in schizophrenia 1 protein isoform f
NM_001164544.2	NP_001158016.1	disrupted in schizophrenia 1 protein isoform g
NM_001164545.2	NP_001158017.1	disrupted in schizophrenia 1 protein isoform h
NM_001164546.2	NP_001158018.1	disrupted in schizophrenia 1 protein isoform i
NM_001164547.2	NP_001158019.1	disrupted in schizophrenia 1 protein isoform i
NM_001164548.2	NP_001158020.1	disrupted in schizophrenia 1 protein isoform k
NM_001164549.2	NP_001158021.1	disrupted in schizophrenia 1 protein isoform l
NM_001164550.2	NP_001158022.1	disrupted in schizophrenia 1 protein isoform m
NM_001164551.2	NP_001158023.1	disrupted in schizophrenia 1 protein isoform n
NM_001164552.2	NP_001158024.1	disrupted in schizophrenia 1 protein isoform o
NM_001164553.2	NP_001158025.1	disrupted in schizophrenia 1 protein isoform p
NM_001164554.2	NP_001158026.1	disrupted in schizophrenia 1 protein isoform q
NM_001164555.2	NP_001158027.1	disrupted in schizophrenia 1 protein isoform r
NM_001164556.2	NP_001158028.1	disrupted in schizophrenia 1 protein isoform t
NM_018662.3	NP_061132.2	disrupted in schizophrenia 1 protein isoform L

Protein Preferred Names

Protein Names

disrupted in schizophrenia 1 protein

Related Diseases

Diseases

Alias

Schizophrenia 9

SCZD9	Schizophrenia 9 With Or Without An Affective Disorder
Schizophrenia Susceptibility Locus, Chromosome 1q42-Related	Schizophrenia 9, Susceptibility To
Schizophrenia Susceptibility Locus Chromosome 1q-Related	Schizophrenia, Type 9

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Cyclothymic Disorder

Cyclothymia	Cycloid Personality
Cyclothymic Personality	Affective Personality Disorder
Cyclothymic Personality Disorder	Cycloid Personality Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Tardive Dyskinesia

Drug-Induced Tardive Dyskinesia	Lingual-Facial-Buccal Dyskinesia
Neuroleptic-Induced Tardive Dyskinesia

Schizophrenia 5

SCZD5	Schizophrenia Susceptibility Locus, Chromosome 6q-Related
Schizophrenia 5 With Or Without An Affective Disorder

Subacute Delirium

Delirium

Acute Confusional State Nos

Paranoid Schizophrenia

Chronic Paranoid Schizophrenia	Paranoid Type Schizophrenia
Paranoid Type Schizophrenia Subchronic State	Paraphrenia - Late
Paraphrenic Schizophrenia	Schizophrenia, Paranoid

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Schizophrenia 2

SCZD2	Schizophrenia Susceptibility Locus, Chromosome 11q-Related
Schizophrenia Susceptibility Locus Chromosome 11q-Related

Schizotypal Personality Disorder

Schizotypal Personality

Schizophrenia 18

SCZD18	Schizophrenia 18 With Or Without An Affective Disorder
Schizophrenia Susceptibility 18	Chromosome 7q36.3 Duplication Syndrome, 362-Kb
Schizophrenia, Type 18

Paranoid Personality Disorder

Schizoid Personality Disorder

Bardet-Biedl Syndrome 4

BBS4	Bardet-Biedl Syndrome, Type 4

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Mental Depression

Depression

Depressive Disorder

Cannabis Abuse

Marijuana Abuse

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Spinocerebellar Ataxia 44

SCA44

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Delusional Disorder

Persistent Delusional Disorders	Delusional Perception
Induced Delusional Disorder

Disease Of Mental Health

Mental Health

Mental Disorders

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Specific Developmental Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108909	Chymopapain		/	Unkown
HY-RS03781	DISC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DISC1	VGNC	VGNC:106712
Felis catus	DISC1	VGNC	VGNC:82471
Canis familiaris	DISC1	VGNC	VGNC:39965
Macaca mulatta	DISC1	VGNC	VGNC:71799
Mus musculus	DISC1	MGD	MGI:2447658
Rattus norvegicus	DISC1	RGD	RGD:631359