Nde1 - nudE neurodevelopment protein 1 Gene

Also Known as Nude; mNudE; 2810027M15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67203

Summary

Enables identical protein binding activity and microtubule binding activity. Involved in centrosome duplication and neuron migration. Acts upstream of or within microtubule nucleation; nervous system development; and vesicle transport along microtubule. Located in spindle pole centrosome and synapse. Is expressed in several structures, including body cavity or lining; brain; early conceptus; integumental system; and vertebral axis musculature. Human ortholog(s) of this gene implicated in lissencephaly 4. Orthologous to human NDE1 (nudE neurodevelopment protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nde1 Products (4)

mRNA Protein Name
NM_001114085.1 NP_001107557.1 nuclear distribution protein nudE homolog 1 isoform b
NM_001285503.1 NP_001272432.1 nuclear distribution protein nudE homolog 1 isoform c
NM_001285504.1 NP_001272433.1 nuclear distribution protein nudE homolog 1 isoform d
NM_023317.2 NP_075806.2 nuclear distribution protein nudE homolog 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15571978 MGI
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
15473967 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11163258 MGI
Biological Process GO Annotation Evidence References Source
involved in centrosome duplication IMP
IMP: Inferred from mutant phenotype
15473967 MGI
acts upstream of or within cerebral cortex development IGI
IGI: Inferred from genetic interaction
18469343 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15473967 MGI
acts upstream of or within microtubule nucleation IDA
IDA: Inferred from direct assay
11163258 MGI
involved in microtubule organizing center organization IMP
IMP: Inferred from mutant phenotype
11163258 MGI
acts upstream of or within neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
15473967 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
11163258 MGI
acts upstream of or within vesicle transport along microtubule IGI
IGI: Inferred from genetic interaction
16107726 MGI
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
11163258 MGI
located in microtubule organizing center IDA
IDA: Inferred from direct assay
11163258 MGI
located in spindle IDA
IDA: Inferred from direct assay
15473967 MGI
located in spindle pole centrosome IDA
IDA: Inferred from direct assay
15473967 MGI
located in synapse IDA
IDA: Inferred from direct assay
18983980 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear distribution protein nudE homolog 1

  • nuclear distribution gene E homolog 1

Nde1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nde1 Q9CZA6 Cenpf Mus musculus Q155P7
Y2H
15939891
Intra
Nde1 Q9CZA6 Cenpf Mus musculus Q155P7
Y2H
11163258
Cross
Nde1 Q9CZA6 DYNC1I1 Homo sapiens O14576
Anti Bait CoIP
19927128
Cross
Nde1 Q9CZA6 PAFAH1B1 Homo sapiens P43034
Y2H
11163258
Cross
Nde1 Q9CZA6 PAFAH1B1 Homo sapiens P43034
Anti Tag CoIP
11163258
Cross
Nde1 Q9CZA6 PAFAH1B1 Homo sapiens P43034
TAP
20360068
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175496 Acid Ceramidase-IN-3 Inhibitor / Unkown
HY-RS09106 NDE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nde1 NCBI NCBI:54820