DYNC1I1 - dynein cytoplasmic 1 intermediate chain 1 Gene

Also Known as DNCI1; DNCIC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1780

About DYNC1I1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:95,772,554-96,110,322 (from NCBI)

This gene has 12 transcripts (splice variants), 257 orthologues and 7 paralogues. Biased expression in brain (RPKM 14.7), adrenal (RPKM 3.3) and 4 other tissues.

Summary

Enables spectrin binding activity. Involved in vesicle transport along microtubule. Located in several cellular components, including kinetochore; recycling endosome; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

DYNC1I1 Products (5)

mRNA	Protein	Name
NM_001135556.2	NP_001129028.1	cytoplasmic dynein 1 intermediate chain 1 isoform b
NM_001135557.2	NP_001129029.1	cytoplasmic dynein 1 intermediate chain 1 isoform c
NM_001278421.2	NP_001265350.1	cytoplasmic dynein 1 intermediate chain 1 isoform d
NM_001278422.2	NP_001265351.1	cytoplasmic dynein 1 intermediate chain 1 isoform e
NM_004411.5	NP_004402.1	cytoplasmic dynein 1 intermediate chain 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14985359	GOA
enables spectrin binding	IDA IDA: Inferred from direct assay	23704327	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	24561039	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25540360	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	19229290	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25540360	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	24561039	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	19229290	GOA
located in vesicle	IDA IDA: Inferred from direct assay	20682791	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNC1I1 Protein Structure

Dynein_IC2

WD40

0
100
200
300
400
500
600
645 a.a.

Protein Preferred Names	Protein Names
cytoplasmic dynein 1 intermediate chain 1	DH IC-1

DYNC1I1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DYNC1I1	O14576	BICD2	Homo sapiens	Q8TD16	Anti Tag CoIP	23664119
Intra	DYNC1I1	O14576	FAM83D	Homo sapiens	Q9H4H8	Anti Tag CoIP	33961781
Intra	DYNC1I1	O14576	FAM83D	Homo sapiens	Q9H4H8	Y2H	21900206
Intra	DYNC1I1	O14576	DYNLRB1	Homo sapiens	Q9NP97	Anti Tag CoIP	33961781
Intra	DYNC1I1	O14576	DYNLRB1	Homo sapiens	Q9NP97	Y2H Pooling	16189514
Intra	DYNC1I1	O14576	DYNLL2	Homo sapiens	Q96FJ2	Y2H Pooling	16189514
Intra	DYNC1I1	O14576	DYNLL2	Homo sapiens	Q96FJ2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Joubert Syndrome 31	JBTS31
Brugada Syndrome 9	BRGDA9 Brugada Syndrome, Type 9
Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive	Split Hand-Foot Malformation 1 With Sensorineural Hearing Loss SHFM1D Deafness, Congenital, With Split Hands And Feet Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss Congenital Deafness With Split Hands And Feet Split Hand-Split Foot-Deafness Syndrome Split Hand-Split Foot-Hearing Loss Syndrome Congenital Deafness And Split Hands And Feet Split-Hand/Foot Malformation, Type 1 With Sensorineural Hearing Loss Split-Hand-Foot Malformation With Sensorineural Hearing Loss
Paranoid Personality Disorder
Immunodeficiency 50	Combined Immunodeficiency Due To Moesin Deficiency IMD50 Immunodeficiency 50, X-Linked Recessive Cid Due To Moesin Deficiency Msn-Related Combined Immunodeficiency X-Linked Moesin-Associated Immunodeficiency Immunodeficiency 50 X Linked Recessive
Split-Hand/Foot Malformation 4	SHFM4 Split Hand-Foot Malformation 4 Split-Hand/Foot Malformation, Type 4
Citrullinemia, Type Ii, Neonatal-Onset	NICCD Citrin Deficiency Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency Citrullinemia, Type Ii, Neonatal-Onset, With Or Without Failure To Thrive And Dyslipidemia Cholestasis, Neonatal Intrahepatic, Caused By Citrin Deficiency Neonatal-Onset Type Ii Citrullinemia Neonatal Intrahepatic Cholestasis Caused By Citrin Deficiency Neonatal-Onset Citrullinemia Type 2 Neonatal-Onset Citrullinemia Type Ii Neonatal-Onset Type 2 Citrullinemia Adult-Onset Citrullinemia Type 2
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3	Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 3 EEC3 Eec Syndrome 3 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome, Type 3
Split Hand-Foot Malformation	Ectrodactyly Split-Hand/Foot Malformation Lobster-Claw Deformity Split-Hand Deformity Split Hand Foot Malformation Shfm Split Hand Foot Deformity Split Hand Foot Deformity 1
Lipoid Proteinosis Of Urbach And Wiethe	Lipoid Proteinosis Urbach-Wiethe Disease Hyalinosis Cutis Et Mucosae Lipid Proteinosis Lipoproteinosis Urbach Wiethe Disease Lipoglycoproteinosis Lipoidosis Cutis Et Mucosae Lipoidproteinosis Urbach-Wiethe Lipoid Proteinosis Urbach-Wiethe Syndrome LIP Proteinosis Lipoid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04083	DYNC1I1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DYNC1I1	VGNC	VGNC:71952
Rattus norvegicus	DYNC1I1	RGD	RGD:2512
Bos taurus	DYNC1I1	VGNC	VGNC:28270
Canis familiaris	DYNC1I1	VGNC	VGNC:40144
Felis catus	DYNC1I1	VGNC	VGNC:61676
Mus musculus	DYNC1I1	MGD	MGI:107743
Others	DYNC1I1	NCBI