DYNLL2 - dynein light chain LC8-type 2 Gene

Homo sapiens

Also known as Dlc2; DNCL1B; RSPH22

Gene ID: 140735 | Gene type: protein coding

About DYNLL2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,083,419-58,095,542 (from NCBI)

This gene has 1 transcript (splice variant), 252 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 120.2), kidney (RPKM 90.1) and 25 other tissues.

Summary

Predicted to enable dynein intermediate chain binding activity and dynein LIGHT intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

DYNLL2 Products(1)

mRNA	Protein	Name
NM_080677.3	NP_542408.1	dynein light chain 2, cytoplasmic

DYNLL2 Protein Structure

Dynein_light

0
89 a.a.

Protein Preferred Names

Protein Names

dynein light chain 2, cytoplasmic

8 kDa dynein light chain b

Related Diseases

Diseases

Alias

Short-Rib Thoracic Dysplasia 11 With Or Without Polydactyly

SRTD11

Bardet-Biedl Syndrome 7

BBS7	Bardet-Biedl Syndrome, Type 7

Louping Ill

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04089	DYNLL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DYNLL2	VGNC	VGNC:98902
Mus musculus	DYNLL2	MGD	MGI:1915347
Rattus norvegicus	DYNLL2	RGD	RGD:619860
Canis familiaris	DYNLL2	VGNC	VGNC:40151
Bos taurus	DYNLL2	VGNC	VGNC:28275

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