2. Gene
  3. HMBOX1 - homeobox containing 1 Gene

HMBOX1 - homeobox containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HOT1; TAH1; PBHNF; HNF1LA

Gene ID: 79618 | Gene type: protein coding

About HMBOX1

Cytogenetic location: 8p21.1-p12 Genomic coordinates (GRCh38): 8:28,890,116-29,053,270 (from NCBI)

This gene has 16 transcripts (splice variants) and 279 orthologues. Ubiquitous expression in adrenal (RPKM 3.8), testis (RPKM 3.5) and 25 other tissues.

Summary

Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of Telomerase activity; and positive regulation of telomere maintenance via Telomerase. Located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

HMBOX1 Products(17)

mRNA Protein Name
NM_001135726.3 NP_001129198.1 homeobox-containing protein 1 isoform 1
NM_001324382.2 NP_001311311.1 homeobox-containing protein 1 isoform 1
NM_001324383.2 NP_001311312.1 homeobox-containing protein 1 isoform 2
NM_001324384.1 NP_001311313.1 homeobox-containing protein 1 isoform 2
NM_001324385.2 NP_001311314.1 homeobox-containing protein 1 isoform 3
NM_001324386.2 NP_001311315.1 homeobox-containing protein 1 isoform 4
NM_001324387.2 NP_001311316.1 homeobox-containing protein 1 isoform 5
NM_001324388.2 NP_001311317.1 homeobox-containing protein 1 isoform 5
NM_001324389.2 NP_001311318.1 homeobox-containing protein 1 isoform 6
NM_001324390.1 NP_001311319.1 homeobox-containing protein 1 isoform 6
NM_001324391.2 NP_001311320.1 homeobox-containing protein 1 isoform 7
NM_001324392.1 NP_001311321.1 homeobox-containing protein 1 isoform 7
NM_001324393.2 NP_001311322.1 homeobox-containing protein 1 isoform 8
NM_001324394.2 NP_001311323.1 homeobox-containing protein 1 isoform 8
NM_001324395.2 NP_001311324.1 homeobox-containing protein 1 isoform 9
NM_001330498.2 NP_001317427.1 homeobox-containing protein 1 isoform 10
NM_024567.4 NP_078843.2 homeobox-containing protein 1 isoform 1

HMBOX1 Protein Structure

HNF-1_N

HNF-1_N: Hepatocyte nuclear factor 1 (HNF-1), N terminus (25 - 228)

Homeobox

Homeobox: Homeobox domain (269 - 339)

  • 0
  • 100
  • 200
  • 300
  • 420 a.a.
Protein Preferred Names Protein Names

homeobox-containing protein 1

homeobox telomere-binding protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06223 HMBOX1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HMBOX1 VGNC VGNC:62823
Macaca mulatta HMBOX1 VGNC VGNC:73443
Rattus norvegicus HMBOX1 RGD RGD:1306787
Canis familiaris HMBOX1 VGNC VGNC:41703
Bos taurus HMBOX1 VGNC VGNC:29869
Mus musculus HMBOX1 MGD MGI:2445066