HMBOX1 - homeobox containing 1 Gene

Also Known as HOT1; TAH1; PBHNF; HNF1LA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79618

About HMBOX1

Cytogenetic location: 8p21.1-p12 Genomic coordinates (GRCh38): 8:28,890,116-29,053,270 (from NCBI)

This gene has 16 transcripts (splice variants) and 279 orthologues. Ubiquitous expression in adrenal (RPKM 3.8), testis (RPKM 3.5) and 25 other tissues.

Summary

Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of Telomerase activity; and positive regulation of telomere maintenance via Telomerase. Located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

HMBOX1 Products (17)

mRNA Protein Name
NM_001135726.3 NP_001129198.1 homeobox-containing protein 1 isoform 1
NM_001324382.2 NP_001311311.1 homeobox-containing protein 1 isoform 1
NM_001324383.2 NP_001311312.1 homeobox-containing protein 1 isoform 2
NM_001324384.1 NP_001311313.1 homeobox-containing protein 1 isoform 2
NM_001324385.2 NP_001311314.1 homeobox-containing protein 1 isoform 3
NM_001324386.2 NP_001311315.1 homeobox-containing protein 1 isoform 4
NM_001324387.2 NP_001311316.1 homeobox-containing protein 1 isoform 5
NM_001324388.2 NP_001311317.1 homeobox-containing protein 1 isoform 5
NM_001324389.2 NP_001311318.1 homeobox-containing protein 1 isoform 6
NM_001324390.1 NP_001311319.1 homeobox-containing protein 1 isoform 6
NM_001324391.2 NP_001311320.1 homeobox-containing protein 1 isoform 7
NM_001324392.1 NP_001311321.1 homeobox-containing protein 1 isoform 7
NM_001324393.2 NP_001311322.1 homeobox-containing protein 1 isoform 8
NM_001324394.2 NP_001311323.1 homeobox-containing protein 1 isoform 8
NM_001324395.2 NP_001311324.1 homeobox-containing protein 1 isoform 9
NM_001330498.2 NP_001317427.1 homeobox-containing protein 1 isoform 10
NM_024567.4 NP_078843.2 homeobox-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded telomeric DNA binding IDA
IDA: Inferred from direct assay
23685356 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23685356 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
23685356 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
23685356 GOA
enables telomeric DNA binding IMP
IMP: Inferred from mutant phenotype
23685356 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19757162 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21839858 GOA
involved in telomere maintenance via telomerase IDA
IDA: Inferred from direct assay
23685356 GOA
involved in telomere-telomerase complex assembly IDA
IDA: Inferred from direct assay
23685356 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
23685356 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19757162 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19757162 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMBOX1 Protein Structure

HNF-1_N

HNF-1_N: Hepatocyte nuclear factor 1 (HNF-1), N terminus (25 - 228)

Homeobox

Homeobox: Homeobox domain (269 - 339)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 420 a.a.
Protein Preferred Names Protein Names

homeobox-containing protein 1

  • homeobox telomere-binding protein 1

HMBOX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HMBOX1 Q6NT76 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 FAM74A4 Homo sapiens Q5TZK3
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 FAM74A4 Homo sapiens Q5TZK3
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 AEBP2 Homo sapiens Q6ZN18-2
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 AEBP2 Homo sapiens Q6ZN18-2
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 AEBP2 Homo sapiens Q6ZN18-2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 POLDIP3 Homo sapiens Q8WUT1
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 POLL Homo sapiens Q9UGP5-2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 MFAP1 Homo sapiens P55081
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 SNRPB2 Homo sapiens P08579
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 SNRPB2 Homo sapiens P08579
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 PRKAA1 Homo sapiens Q13131
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 FGF11 Homo sapiens Q92914
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ASB7 Homo sapiens Q9H672-2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ASB7 Homo sapiens Q9H672-2
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 ASB7 Homo sapiens Q9H672-2
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 PRKAA2 Homo sapiens P54646
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 PRKAA2 Homo sapiens P54646
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 PRKAA2 Homo sapiens P54646
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 ZMYM5 Homo sapiens Q9UJ78-2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 FAM217B Homo sapiens Q9NTX9
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 FAM217B Homo sapiens Q9NTX9
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 FAM217B Homo sapiens Q9NTX9
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 SAP30L Homo sapiens Q9HAJ7
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 SAP30L Homo sapiens Q9HAJ7
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 FARS2 Homo sapiens O95363
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 FARS2 Homo sapiens O95363
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 FARS2 Homo sapiens O95363
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 DYNLL2 Homo sapiens Q96FJ2
Y2H Array
31515488
Intra
HMBOX1 Q6NT76 ZMAT2 Homo sapiens Q96NC0
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 ZMAT2 Homo sapiens Q96NC0
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 DNTTIP1 Homo sapiens Q9H147
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 DNTTIP1 Homo sapiens Q9H147
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 DNTTIP1 Homo sapiens Q9H147
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 MCRS1 Homo sapiens Q96EZ8
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 MCRS1 Homo sapiens Q96EZ8
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 XRCC6 Homo sapiens P12956
Anti Bait CoIP
23685356
Intra
HMBOX1 Q6NT76 ATP5PO Homo sapiens P48047
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 BYSL Homo sapiens Q13895
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 RPL9 Homo sapiens P32969
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 RPL9 Homo sapiens P32969
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 RPL9 Homo sapiens P32969
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 CCNG1 Homo sapiens P51959
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 CCNG1 Homo sapiens P51959
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 ASB7 Homo sapiens Q9H672
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 ZBTB26 Homo sapiens Q9HCK0
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 KAT5 Homo sapiens Q92993
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 KAT5 Homo sapiens Q92993
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 KAT5 Homo sapiens Q92993
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 VPS72 Homo sapiens Q15906
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 VPS72 Homo sapiens Q15906
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 MORF4L1 Homo sapiens Q9UBU8
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 MAGEH1 Homo sapiens Q9H213
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 UBA6 Homo sapiens A0AVT1
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 MRPL11 Homo sapiens Q9Y3B7
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 MRPL11 Homo sapiens Q9Y3B7
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 DKC1 Homo sapiens O60832
Anti Bait CoIP
23685356
Intra
HMBOX1 Q6NT76 ZNF337 Homo sapiens Q9Y3M9
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 ZNF337 Homo sapiens Q9Y3M9
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 ZNF337 Homo sapiens Q9Y3M9
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 C8orf33 Homo sapiens Q9H7E9
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 C8orf33 Homo sapiens Q9H7E9
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 INO80B Homo sapiens Q9C086
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 FAM161A Homo sapiens Q3B820
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 FAM161A Homo sapiens Q3B820
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 UBE2Z Homo sapiens Q9H832
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 UBE2Z Homo sapiens Q9H832
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 MRPL28 Homo sapiens Q13084
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ZBTB24 Homo sapiens O43167
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 ZBTB24 Homo sapiens O43167
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 FNDC11 Homo sapiens Q9BVV2
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 FNDC11 Homo sapiens Q9BVV2
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ZNF581 Homo sapiens Q9P0T4
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 GNL3L Homo sapiens Q9NVN8
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 IPO13 Homo sapiens O94829
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 IPO13 Homo sapiens O94829
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 REEP6 Homo sapiens Q96HR9
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 REEP6 Homo sapiens Q96HR9
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 FAM13C Homo sapiens Q8NE31
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 FAM13C Homo sapiens Q8NE31
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 CARD9 Homo sapiens Q9H257
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 CARD9 Homo sapiens Q9H257
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 DAB1 Homo sapiens O75553
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 DAB1 Homo sapiens O75553
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 DAB1 Homo sapiens O75553
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
HMBOX1 Q6NT76 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 GAS2L2 Homo sapiens Q8NHY3
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ABITRAM Homo sapiens Q9NX38
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 ABITRAM Homo sapiens Q9NX38
Validated Y2H
32296183
Intra
HMBOX1 Q6NT76 ABITRAM Homo sapiens Q9NX38
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 PIP4K2B Homo sapiens P78356
Validated Y2H
25416956
Intra
HMBOX1 Q6NT76 PIP4K2B Homo sapiens P78356
Y2H Prey Pooling
25416956
Intra
HMBOX1 Q6NT76 PIP4K2B Homo sapiens P78356
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 TCEANC Homo sapiens Q8N8B7
Y2H Array
25416956
Intra
HMBOX1 Q6NT76 CDCA8 Homo sapiens Q53HL2
Y2H Prey Pooling
32296183
Intra
HMBOX1 Q6NT76 CDCA8 Homo sapiens Q53HL2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06223 HMBOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HMBOX1 VGNC VGNC:62823
Macaca mulatta HMBOX1 VGNC VGNC:73443
Rattus norvegicus HMBOX1 RGD RGD:1306787
Canis familiaris HMBOX1 VGNC VGNC:41703
Bos taurus HMBOX1 VGNC VGNC:29869
Mus musculus HMBOX1 MGD MGI:2445066
Others HMBOX1 NCBI