VPS72 - vacuolar protein sorting 72 homolog Gene

Also Known as YL1; CFL1; Swc2; YL-1; TCFL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6944

About VPS72

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,176,304-151,190,197 (from NCBI)

This gene has 5 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in brain (RPKM 14.7), prostate (RPKM 14.0) and 25 other tissues.

Summary

The protein encoded by this gene is a shared subunit of two multi-component complexes, the Histone Acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and Apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

VPS72 Products (3)

mRNA	Protein	Name
NM_001271087.2	NP_001258016.1	vacuolar protein sorting-associated protein 72 homolog isoform 1
NM_001271088.2	NP_001258017.1	vacuolar protein sorting-associated protein 72 homolog isoform 3
NM_005997.3	NP_005988.1	vacuolar protein sorting-associated protein 72 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone binding	IPI IPI: Inferred from physical interaction	26974126	GOA
enables histone chaperone activity	IMP IMP: Inferred from mutant phenotype	26974126	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15647280	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	27153538	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27153538	GOA
involved in transcription initiation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	26974126	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NuA4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	27153538	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27153538	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14966270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS72 Protein Structure

YL1

YL1_C

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 72 homolog	transcription factor-like 1

VPS72 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS72	Q15906	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	VPS72	Q15906	RUVBL1	Homo sapiens	Q9Y265	Anti Bait CoIP	15647280
Intra	VPS72	Q15906	RUVBL1	Homo sapiens	Q9Y265	Anti Tag CoIP	15647280
Intra	VPS72	Q15906	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	VPS72	Q15906	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	VPS72	Q15906	MDFI	Homo sapiens	Q99750	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Peripheral Neuropathy With Variable Spasticity, Exercise Intolerance, And Developmental Delay	Combined Oxidative Phosphorylation Deficiency 26 COXPD26 Combined Oxidative Phosphorylation Defect Type 26 PNSED Oxidative Phosphorylation Deficiency, Combined, Type 26
Brain Compression	Compression Of Brain
Amyotrophic Lateral Sclerosis Type 5	Amyotrophic Lateral Sclerosis 5 Als5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15700	VPS72 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VPS72	VGNC	VGNC:36831
Rattus norvegicus	VPS72	RGD	RGD:1306121
Felis catus	VPS72	VGNC	VGNC:66975
Mus musculus	VPS72	MGD	MGI:1202305
Canis familiaris	VPS72	VGNC	VGNC:48299
Macaca mulatta	VPS72	VGNC	VGNC:78560
Others	VPS72	NCBI