UBE2Z - ubiquitin conjugating enzyme E2 Z Gene

Also Known as USE1; HOYS7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65264

About UBE2Z

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,908,407-48,929,056 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 24 paralogues. Ubiquitous expression in thyroid (RPKM 33.3), brain (RPKM 25.6) and 25 other tissues.

Summary

This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and Apoptosis. [provided by RefSeq, Feb 2012]

UBE2Z Products (1)

mRNA Protein Name
NM_023079.5 NP_075567.2 ubiquitin-conjugating enzyme E2 Z

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
26555268 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
17464193 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17464193 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2Z Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (103 - 231)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 Z

  • E2 ubiquitin-conjugating enzyme Z

UBE2Z Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2Z Q9H832 PLEKHA6 Homo sapiens Q9Y2H5
Validated Y2H
32296183
Intra
UBE2Z Q9H832 PLEKHA6 Homo sapiens Q9Y2H5
Y2H Array
32296183
Intra
UBE2Z Q9H832 PLEKHA6 Homo sapiens Q9Y2H5
Y2H Prey Pooling
32296183
Intra
UBE2Z Q9H832 TRIM3 Homo sapiens O75382
Y2H Prey Pooling
32296183
Intra
UBE2Z Q9H832 TRIM3 Homo sapiens O75382
Y2H Array
32296183
Intra
UBE2Z Q9H832 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
25416956
Intra
UBE2Z Q9H832 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
UBE2Z Q9H832 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
UBE2Z Q9H832 CCT3 Homo sapiens P49368
Y2H Prey Pooling
32296183
Intra
UBE2Z Q9H832 CCT3 Homo sapiens P49368
Y2H Array
32296183
Intra
UBE2Z Q9H832 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
UBE2Z Q9H832 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
UBE2Z Q9H832 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
UBE2Z Q9H832 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
UBE2Z Q9H832 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
UBE2Z Q9H832 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
UBE2Z Q9H832 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
UBE2Z Q9H832 PLEKHF2 Homo sapiens Q9H8W4
Y2H Pooling
16189514
Intra
UBE2Z Q9H832 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
UBE2Z Q9H832 AK8 Homo sapiens Q96MA6
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2Z Proteins

Cat. No. Product Name Accession Purity
HY-P71412 UBE2Z Protein, Human (His) Q9H832-2 (M1-V246) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15367 UBE2Z Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21072 Ube2z Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27589 Ube2z Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBE2Z VGNC VGNC:104671
Canis familiaris UBE2Z VGNC VGNC:48067
Felis catus UBE2Z VGNC VGNC:99568
Rattus norvegicus UBE2Z RGD RGD:1308347
Bos taurus UBE2Z VGNC VGNC:36598
Mus musculus UBE2Z MGD MGI:1343160
Others UBE2Z NCBI