2. Gene
  3. TRIM3 - tripartite motif containing 3 Gene

TRIM3 - tripartite motif containing 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BERP; HAC1; RNF22; RNF97

Gene ID: 10612 | Gene type: protein coding

About TRIM3

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,448,613-6,474,459 (from NCBI)

This gene has 14 transcripts (splice variants), 266 orthologues and 80 paralogues. Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of Myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in Myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

TRIM3 Products(4)

mRNA Protein Name
NM_001248006.2 NP_001234935.1 tripartite motif-containing protein 3 isoform 1
NM_001248007.2 NP_001234936.1 tripartite motif-containing protein 3 isoform 2
NM_006458.4 NP_006449.2 tripartite motif-containing protein 3 isoform 1
NM_033278.4 NP_150594.2 tripartite motif-containing protein 3 isoform 1

TRIM3 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (22 - 62)

zf-B_box

zf-B_box: B-box zinc finger (113 - 150)

Filamin

Filamin: Filamin/ABP280 repeat (321 - 415)

NHL

NHL: NHL repeat (486 - 513)

NHL

NHL: NHL repeat (533 - 560)

NHL

NHL: NHL repeat (577 - 602)

NHL

NHL: NHL repeat (622 - 649)

NHL

NHL: NHL repeat (669 - 696)

NHL

NHL: NHL repeat (713 - 737)

  • 0
  • 200
  • 400
  • 600
  • 744 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 3

RING finger protein 97

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15035 TRIM3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIM3 VGNC VGNC:66533
Macaca mulatta TRIM3 VGNC VGNC:78549
Rattus norvegicus TRIM3 RGD RGD:70074
Mus musculus TRIM3 MGD MGI:1860040
Canis familiaris TRIM3 VGNC VGNC:47813
Bos taurus TRIM3 VGNC VGNC:36326
Others TRIM3 NCBI