2. Gene
  3. TRIM2 - tripartite motif containing 2 Gene

TRIM2 - tripartite motif containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CMT2R; RNF86

Gene ID: 23321 | Gene type: protein coding

About TRIM2

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:153,152,163-153,339,317 (from NCBI)

This gene has 90 transcripts (splice variants), 276 orthologues, 80 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 37.2), thyroid (RPKM 33.2) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

TRIM2 Products(24)

mRNA Protein Name
NM_001130067.2 NP_001123539.1 tripartite motif-containing protein 2 isoform 2
NM_001302692.2 NP_001289621.1 tripartite motif-containing protein 2 isoform 3
NM_001302693.2 NP_001289622.1 tripartite motif-containing protein 2 isoform 4
NM_001302694.2 NP_001289623.1 tripartite motif-containing protein 2 isoform 5
NM_001351054.2 NP_001337983.1 tripartite motif-containing protein 2 isoform 6
NM_001351055.2 NP_001337984.1 tripartite motif-containing protein 2 isoform 7
NM_001351056.2 NP_001337985.1 tripartite motif-containing protein 2 isoform 8
NM_001351057.2 NP_001337986.1 tripartite motif-containing protein 2 isoform 9
NM_001375488.1 NP_001362417.1 tripartite motif-containing protein 2 isoform 10
NM_001375489.1 NP_001362418.1 tripartite motif-containing protein 2 isoform 11
NM_001375490.1 NP_001362419.1 tripartite motif-containing protein 2 isoform 12
NM_001375491.1 NP_001362420.1 tripartite motif-containing protein 2 isoform 13
NM_001375512.1 NP_001362441.1 tripartite motif-containing protein 2 isoform 2
NM_001375513.1 NP_001362442.1 tripartite motif-containing protein 2 isoform 2
NM_001375514.1 NP_001362443.1 tripartite motif-containing protein 2 isoform 2
NM_001375515.1 NP_001362444.1 tripartite motif-containing protein 2 isoform 2
NM_001375516.1 NP_001362445.1 tripartite motif-containing protein 2 isoform 2
NM_001375517.1 NP_001362446.1 tripartite motif-containing protein 2 isoform 2
NM_001375519.1 NP_001362448.1 tripartite motif-containing protein 2 isoform 14
NM_001375520.1 NP_001362449.1 tripartite motif-containing protein 2 isoform 15
NM_001375522.1 NP_001362451.1 tripartite motif-containing protein 2 isoform 16
NM_001375523.1 NP_001362452.1 tripartite motif-containing protein 2 isoform 16
NM_001375525.1 NP_001362454.1 tripartite motif-containing protein 2 isoform 16
NM_015271.5 NP_056086.2 tripartite motif-containing protein 2 isoform 1

TRIM2 Protein Structure

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (23 - 63)

zf-B_box

zf-B_box: B-box zinc finger (116 - 154)

Filamin

Filamin: Filamin/ABP280 repeat (323 - 418)

NHL

NHL: NHL repeat (486 - 513)

NHL

NHL: NHL repeat (533 - 560)

NHL

NHL: NHL repeat (577 - 602)

NHL

NHL: NHL repeat (622 - 649)

NHL

NHL: NHL repeat (669 - 696)

NHL

NHL: NHL repeat (713 - 740)

  • 0
  • 200
  • 400
  • 600
  • 744 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 2

Charcot-Marie-Tooth disease, type 2R

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2r

Charcot-Marie-Tooth Disease Type 2r

CMT2R

Charcot-Marie-Tooth Neuropathy, Type 2r

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2r

Charcot-Marie-Tooth Disease, Type 2r

Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2r

Charcot-Marie-Tooth Neuropathy Type 2r

Charcot-Marie-Tooth Disease 2r

Autosomal Recessive Charcot-Marie-Tooth Disease Axonal Type 2r

Charcot-Marie-Tooth Disease Axonal Type 2r

Charcot-Marie-Tooth Neuropathy Axonal Type 2r
Axonal Neuropathy
Charcot-Marie-Tooth Disease, Axonal, Type 2t

CMT2T

Charcot-Marie-Tooth Disease Axonal Type 2t

Charcot-Marie-Tooth Neuropathy, Type 2t

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2t

Ar-Cmt2t

Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2t

Mme-Related Autosomal Dominant Charcot Marie Tooth Disease Type 2

Charcot-Marie-Tooth Neuropathy Type 2t

Charcot-Marie-Tooth Disease Type 2t

Mme-Related Autosomal Dominant Cmt2

Mme-Related Autosomal Dominant Hereditary Motor And Sensory Neuropathy Type 2

Charcot-Marie-Tooth Disease 2t

Charcot-Marie-Tooth Neuropathy Axonal Type 2t
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Tooth Disease

Tooth Diseases

Teeth Disease

Tooth Disorders
Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2

CMT2E

CMT2S

CMT2Y

Charcot-Marie-Tooth Disease Type 2e

Charcot-Marie-Tooth Disease Type 2y

Charcot-Marie-Tooth Disease Axonal Type 2s

Charcot-Marie-Tooth Disease, Axonal, Type 2s

Charcot-Marie-Tooth Disease, Type 2e

Hereditary Motor And Sensory Neuropathy Type 2

Charcot-Marie-Tooth Neuropathy, Type 2s

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s

Charcot-Marie-Tooth Disease, Axonal, Type 2y

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y

Charcot-Marie-Tooth Neuropathy, Type 2y

Charcot-Marie-Tooth Disease, Type 2y

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e

Charcot-Marie-Tooth Neuropathy Type 2e

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation

Cmt2 Due To Vcp Mutation

Charcot-Marie-Tooth Disease Type 2s

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease

Cmt2

Charcot-Marie-Tooth Neuropathy, Type 2e

Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type

Hereditary Motor And Sensory Neuropathy Okinawa Type

Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y

Charcot-Marie-Tooth Neuropathy Type 2y

Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s

Charcot-Marie-Tooth Neuropathy Type 2s

Charcot-Marie-Tooth Type 2

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y

Charcot-Marie-Tooth Disease 2e

Charcot-Marie-Tooth Disease Axonal Type 2e

Charcot-Marie-Tooth Disease Neuronal Type 2e

Charcot-Marie-Tooth Disease 2s

Charcot-Marie-Tooth Neuropathy Axonal Type 2s

Charcot-Marie-Tooth Disease 2y

Charcot-Marie-Tooth Disease, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii
Charcot-Marie-Tooth Disease, Axonal, Type 2p

CMT2P

Charcot-Marie-Tooth Disease Axonal Type 2p

Charcot-Marie-Tooth Disease Type 2p

Charcot-Marie-Tooth Neuropathy, Type 2p

Charcot-Marie-Tooth Disease, Axonal, Type 2g, Formerly

Cmt2g, Formerly

Charcot-Marie-Tooth Neuropathy Type 2p

Charcot-Marie-Toothe Disease, Axonal, Type 2p

Charcot-Marie-Tooth Disease 2p

Charcot-Marie-Tooth Disease, Axonal Type 2g

Charcot-Marie-Tooth Neuropathy Axonal Type 2p

Cmt2g

Charcot-Marie-Tooth Disease, Type 2p

Charcot-Marie-Tooth Disease, Axonal, Type 2g
Charcot-Marie-Tooth Disease, Recessive Intermediate D

Charcot-Marie-Tooth Disease Recessive Intermediate D

CMTRID

Autosomal Recessive Intermediate Charcot-Marie-Tooth Disease Type D

Ri-Cmt Type D

Charcot-Marie-Tooth Disease, Recessive, Intermediate Type, D
Charcot-Marie-Tooth Disease, Axonal, Type 2b2

Charcot-Marie-Tooth Disease Type 2b2

CMT2B2

Arcmt2b

Charcot-Marie-Tooth Disease, Type 2b2

Ar-Cmt2b2

Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b2

Autosomal Recessive Axonal Cmt4c3

Charcot-Marie-Tooth Disease Neuronal Type 2b2

Charcot-Marie-Tooth Neuropathy Type 2b2

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b2

Charcot-Marie-Tooth Disease, Neuronal, Type 2b2

Charcot-Marie-Tooth Neuropathy, Type 2b2

Charcot-Marie-Tooth Disease 2b2

Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B2

Charcot-Marie-Tooth Disease Axonal Type 2b2
Charcot-Marie-Tooth Disease Type 2a2a

Charcot-Marie-Tooth Disease, Type 2a2a

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2a2

Charcot-Marie-Tooth Neuronal Type 2a2

Charcot-Marie-Tooth Neuropathy Type 2a2

Cmt2a2a

Hereditary Motor And Sensory Neuropathy Iia2

Hmsn Iia2

Hmsn2a2
Charcot-Marie-Tooth Disease, Axonal, Type 2h

CMT2H

Charcot-Marie-Tooth Disease Axonal Type 2h

Ar-Cmt2c

Autosomal Recessive Axonal Cmt4c2

Axonal Charcot-Marie-Tooth Disease With Pyramidal Involvement

Charcot-Marie-Tooth Disease Type 2h

Charcot-Marie-Tooth Disease, Axonal, With Pyramidal Features, Autosomal Recessive

Charcot-Marie-Tooth Neuropathy, Axonal, With Pyramidal Features, Autosomal Recessive

Autosomal Recessive Axonal Charcot-Marie-Tooth Disease With Pyramidal Features

Autosomal Recessive Axonal Charcot-Marie-Tooth Neuropathy With Pyramidal Features

Charcot-Marie-Tooth Disease, Type 2h
Charcot-Marie-Tooth Disease, Axonal, Type 2b1

Charcot-Marie-Tooth Disease Type 2b1

Charcot-Marie-Tooth Disease, Type 2b1

CMT2B1

Autosomal Recessive Axonal Cmt4c1

Autosomal Recessive Charcot-Marie-Tooth Disease Type 2b1

Charcot-Marie-Tooth Disease Neuronal Type 2b1

Charcot-Marie-Tooth Neuropathy Type 2b1

Charcot-Marie-Tooth Disease, Neuronal, Type 2b1

Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b1

Charcot-Marie-Tooth Neuropathy, Type 2b1

Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b1

Ar-Cmt2b1

Charcot-Marie-Tooth Disease 2b1

Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B1

Charcot-Marie-Tooth Disease Axonal Type 2b1
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4

Charcot-Marie-Tooth Disease Type 4e

Hereditary Motor And Sensory Neuropathy

Cmt4e

CHN1

Hypomyelinating Neuropathy, Congenital, 1

Charcot-Marie-Tooth Neuropathy Type 4e

Neuropathy, Congenital Hypomyelinating, 1

Ar-Cmt1

Autosomal Recessive Demyelinating Charcot-Marie-Tooth

Cmt4

Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive

Hypomyelination, Severe Congenital

Charcot-Marie-Tooth Disease, Type 4e

Charcot-Marie-Tooth Neuropathy, Type 4e

Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy

Autosomal Recessive Congenital Hypomyelinating Neuropathy

Congenital Amyelinating Neuropathy

Congenital Hypomyelinating Neuropathy Autosomal Recessive

Neuropathy, Congenital Hypomyelinating Or Amyelinating

Severe Congenital Hypomyelination

Hereditary Sensory Motor Neuropathy

Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive

Neuropathy, Hypomyelinating, Congenital, Type 1

Neuropathy, Motor And Sensory, Hereditary

Congenital Hypomyelinating Neuropathy

Hereditary Motor And Sensory Neuropathies

Hereditary Sensorimotor Neuropathy

Hmsn - [Hereditary Motor And Sensory Neuropathy]

Hsmn - [Hereditary Sensory And Motor Neuropathy]

Hereditary Motor And Sensory Neuropathy, Types I-Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15025 TRIM2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIM2 VGNC VGNC:36318
Mus musculus TRIM2 MGD MGI:1933163
Felis catus TRIM2 VGNC VGNC:66529
Rattus norvegicus TRIM2 RGD RGD:1310981
Others TRIM2 NCBI