TRIM2 - tripartite motif containing 2 Gene

Also Known as CMT2R; RNF86

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23321

About TRIM2

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:153,152,163-153,339,317 (from NCBI)

This gene has 90 transcripts (splice variants), 276 orthologues, 80 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 37.2), thyroid (RPKM 33.2) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin Ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

TRIM2 Products (24)

mRNA	Protein	Name
NM_001130067.2	NP_001123539.1	tripartite motif-containing protein 2 isoform 2
NM_001302692.2	NP_001289621.1	tripartite motif-containing protein 2 isoform 3
NM_001302693.2	NP_001289622.1	tripartite motif-containing protein 2 isoform 4
NM_001302694.2	NP_001289623.1	tripartite motif-containing protein 2 isoform 5
NM_001351054.2	NP_001337983.1	tripartite motif-containing protein 2 isoform 6
NM_001351055.2	NP_001337984.1	tripartite motif-containing protein 2 isoform 7
NM_001351056.2	NP_001337985.1	tripartite motif-containing protein 2 isoform 8
NM_001351057.2	NP_001337986.1	tripartite motif-containing protein 2 isoform 9
NM_001375488.1	NP_001362417.1	tripartite motif-containing protein 2 isoform 10
NM_001375489.1	NP_001362418.1	tripartite motif-containing protein 2 isoform 11
NM_001375490.1	NP_001362419.1	tripartite motif-containing protein 2 isoform 12
NM_001375491.1	NP_001362420.1	tripartite motif-containing protein 2 isoform 13
NM_001375512.1	NP_001362441.1	tripartite motif-containing protein 2 isoform 2
NM_001375513.1	NP_001362442.1	tripartite motif-containing protein 2 isoform 2
NM_001375514.1	NP_001362443.1	tripartite motif-containing protein 2 isoform 2
NM_001375515.1	NP_001362444.1	tripartite motif-containing protein 2 isoform 2
NM_001375516.1	NP_001362445.1	tripartite motif-containing protein 2 isoform 2
NM_001375517.1	NP_001362446.1	tripartite motif-containing protein 2 isoform 2
NM_001375519.1	NP_001362448.1	tripartite motif-containing protein 2 isoform 14
NM_001375520.1	NP_001362449.1	tripartite motif-containing protein 2 isoform 15
NM_001375522.1	NP_001362451.1	tripartite motif-containing protein 2 isoform 16
NM_001375523.1	NP_001362452.1	tripartite motif-containing protein 2 isoform 16
NM_001375525.1	NP_001362454.1	tripartite motif-containing protein 2 isoform 16
NM_015271.5	NP_056086.2	tripartite motif-containing protein 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21478148	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11331580	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM2 Protein Structure

zf-C3HC4_2

zf-B_box

Filamin

NHL

0
200
400
600
744 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 2	Charcot-Marie-Tooth disease, type 2R

TRIM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM2	Q9C040	CIB3	Homo sapiens	Q96Q77	Y2H Prey Pooling	25416956
Intra	TRIM2	Q9C040	CIB3	Homo sapiens	Q96Q77	Validated Y2H	25416956
Intra	TRIM2	Q9C040	KCTD7	Homo sapiens	Q96MP8-2	Y2H Array	32296183
Intra	TRIM2	Q9C040	KCTD7	Homo sapiens	Q96MP8-2	Y2H Prey Pooling	32296183
Intra	TRIM2	Q9C040	TRIM3	Homo sapiens	O75382	Anti Tag CoIP	33961781
Intra	TRIM2	Q9C040	TRIM3	Homo sapiens	O75382	Anti Tag CoIP	28514442
Intra	TRIM2	Q9C040	TRIM3	Homo sapiens	O75382	Y2H Array	32296183
Intra	TRIM2	Q9C040	TRIM3	Homo sapiens	O75382	Y2H Prey Pooling	32296183
Intra	TRIM2	Q9C040	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	TRIM2	Q9C040	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	TRIM2	Q9C040	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	TRIM2	Q9C040	UBAC1	Homo sapiens	Q9BSL1	Y2H Array	32296183
Intra	TRIM2	Q9C040	UBAC1	Homo sapiens	Q9BSL1	Y2H Prey Pooling	32296183
Intra	TRIM2	Q9C040	LRRC8E	Homo sapiens	Q6NSJ5	Anti Tag CoIP	33961781
Intra	TRIM2	Q9C040	LRRC8E	Homo sapiens	Q6NSJ5	Y2H	21516116
Intra	TRIM2	Q9C040	COG3	Homo sapiens	Q96JB2-2	Y2H Prey Pooling	32296183
Intra	TRIM2	Q9C040	COG3	Homo sapiens	Q96JB2-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2r	Charcot-Marie-Tooth Disease Type 2r CMT2R Charcot-Marie-Tooth Neuropathy, Type 2r Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2r Charcot-Marie-Tooth Disease, Type 2r Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2r Charcot-Marie-Tooth Neuropathy Type 2r Charcot-Marie-Tooth Disease 2r Autosomal Recessive Charcot-Marie-Tooth Disease Axonal Type 2r Charcot-Marie-Tooth Disease Axonal Type 2r Charcot-Marie-Tooth Neuropathy Axonal Type 2r
Axonal Neuropathy
Charcot-Marie-Tooth Disease, Axonal, Type 2t	CMT2T Charcot-Marie-Tooth Disease Axonal Type 2t Charcot-Marie-Tooth Neuropathy, Type 2t Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2t Ar-Cmt2t Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2t Mme-Related Autosomal Dominant Charcot Marie Tooth Disease Type 2 Charcot-Marie-Tooth Neuropathy Type 2t Charcot-Marie-Tooth Disease Type 2t Mme-Related Autosomal Dominant Cmt2 Mme-Related Autosomal Dominant Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Disease 2t Charcot-Marie-Tooth Neuropathy Axonal Type 2t
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Tooth Disease	Tooth Diseases Teeth Disease Tooth Disorders
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Charcot-Marie-Tooth Disease, Axonal, Type 2p	CMT2P Charcot-Marie-Tooth Disease Axonal Type 2p Charcot-Marie-Tooth Disease Type 2p Charcot-Marie-Tooth Neuropathy, Type 2p Charcot-Marie-Tooth Disease, Axonal, Type 2g, Formerly Cmt2g, Formerly Charcot-Marie-Tooth Neuropathy Type 2p Charcot-Marie-Toothe Disease, Axonal, Type 2p Charcot-Marie-Tooth Disease 2p Charcot-Marie-Tooth Disease, Axonal Type 2g Charcot-Marie-Tooth Neuropathy Axonal Type 2p Cmt2g Charcot-Marie-Tooth Disease, Type 2p Charcot-Marie-Tooth Disease, Axonal, Type 2g
Charcot-Marie-Tooth Disease, Recessive Intermediate D	Charcot-Marie-Tooth Disease Recessive Intermediate D CMTRID Autosomal Recessive Intermediate Charcot-Marie-Tooth Disease Type D Ri-Cmt Type D Charcot-Marie-Tooth Disease, Recessive, Intermediate Type, D
Charcot-Marie-Tooth Disease, Axonal, Type 2b2	Charcot-Marie-Tooth Disease Type 2b2 CMT2B2 Arcmt2b Charcot-Marie-Tooth Disease, Type 2b2 Ar-Cmt2b2 Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b2 Autosomal Recessive Axonal Cmt4c3 Charcot-Marie-Tooth Disease Neuronal Type 2b2 Charcot-Marie-Tooth Neuropathy Type 2b2 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b2 Charcot-Marie-Tooth Disease, Neuronal, Type 2b2 Charcot-Marie-Tooth Neuropathy, Type 2b2 Charcot-Marie-Tooth Disease 2b2 Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B2 Charcot-Marie-Tooth Disease Axonal Type 2b2
Charcot-Marie-Tooth Disease Type 2a2a	Charcot-Marie-Tooth Disease, Type 2a2a Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2a2 Charcot-Marie-Tooth Neuronal Type 2a2 Charcot-Marie-Tooth Neuropathy Type 2a2 Cmt2a2a Hereditary Motor And Sensory Neuropathy Iia2 Hmsn Iia2 Hmsn2a2
Charcot-Marie-Tooth Disease, Axonal, Type 2h	CMT2H Charcot-Marie-Tooth Disease Axonal Type 2h Ar-Cmt2c Autosomal Recessive Axonal Cmt4c2 Axonal Charcot-Marie-Tooth Disease With Pyramidal Involvement Charcot-Marie-Tooth Disease Type 2h Charcot-Marie-Tooth Disease, Axonal, With Pyramidal Features, Autosomal Recessive Charcot-Marie-Tooth Neuropathy, Axonal, With Pyramidal Features, Autosomal Recessive Autosomal Recessive Axonal Charcot-Marie-Tooth Disease With Pyramidal Features Autosomal Recessive Axonal Charcot-Marie-Tooth Neuropathy With Pyramidal Features Charcot-Marie-Tooth Disease, Type 2h
Charcot-Marie-Tooth Disease, Axonal, Type 2b1	Charcot-Marie-Tooth Disease Type 2b1 Charcot-Marie-Tooth Disease, Type 2b1 CMT2B1 Autosomal Recessive Axonal Cmt4c1 Autosomal Recessive Charcot-Marie-Tooth Disease Type 2b1 Charcot-Marie-Tooth Disease Neuronal Type 2b1 Charcot-Marie-Tooth Neuropathy Type 2b1 Charcot-Marie-Tooth Disease, Neuronal, Type 2b1 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b1 Charcot-Marie-Tooth Neuropathy, Type 2b1 Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b1 Ar-Cmt2b1 Charcot-Marie-Tooth Disease 2b1 Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B1 Charcot-Marie-Tooth Disease Axonal Type 2b1
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15025	TRIM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18191	Trim2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24665	Trim2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIM2	VGNC	VGNC:36318
Mus musculus	TRIM2	MGD	MGI:1933163
Felis catus	TRIM2	VGNC	VGNC:66529
Rattus norvegicus	TRIM2	RGD	RGD:1310981
Others	TRIM2	NCBI