LRRC8E - leucine rich repeat containing 8 VRAC subunit E Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80131

Summary

This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Broad expression in skin (RPKM 1.3), prostate (RPKM 0.9) and 17 other tissues.

LRRC8E Products (1)

mRNA Protein Name
NG_050684.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables volume-sensitive anion channel activity IDA
IDA: Inferred from direct assay
33139539 GOA
contributes to volume-sensitive anion channel activity IMP
IMP: Inferred from mutant phenotype
28193731 GOA
enables volume-sensitive anion channel activity IMP
IMP: Inferred from mutant phenotype
26824658 GOA
Biological Process GO Annotation Evidence References Source
involved in aspartate transmembrane transport IMP
IMP: Inferred from mutant phenotype
28193731 GOA
involved in cell volume homeostasis IDA
IDA: Inferred from direct assay
33139539 GOA
involved in cellular response to osmotic stress IMP
IMP: Inferred from mutant phenotype
28193731 GOA
involved in cyclic-GMP-AMP transmembrane import across plasma membrane IDA
IDA: Inferred from direct assay
33171122 GOA
involved in monoatomic anion transmembrane transport IMP
IMP: Inferred from mutant phenotype
24790029 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24790029 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
33139539 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
33139539 GOA
part of monoatomic ion channel complex IMP
IMP: Inferred from mutant phenotype
28193731 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
24790029 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
26824658 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC8E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRC8E Q6NSJ5 SAMD4B Homo sapiens Q5PRF9
Y2H Array
32296183
Intra
LRRC8E Q6NSJ5 SAMD4B Homo sapiens Q5PRF9
Y2H Prey Pooling
32296183
Intra
LRRC8E Q6NSJ5 TRIM3 Homo sapiens O75382
Y2H Prey Pooling
32296183
Intra
LRRC8E Q6NSJ5 TRIM3 Homo sapiens O75382
Y2H Array
32296183
Intra
LRRC8E Q6NSJ5 GPSM2 Homo sapiens P81274
Y2H Prey Pooling
32296183
Intra
LRRC8E Q6NSJ5 GPSM2 Homo sapiens P81274
Y2H Array
32296183
Intra
LRRC8E Q6NSJ5 TRIM2 Homo sapiens Q9C040
Y2H Prey Pooling
32296183
Intra
LRRC8E Q6NSJ5 TRIM2 Homo sapiens Q9C040
Validated Y2H
32296183
Intra
LRRC8E Q6NSJ5 TRIM2 Homo sapiens Q9C040
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07827 LRRC8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07828 LRRC8B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07829 LRRC8C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21148 Lrrc8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27665 Lrrc8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown