SAMD4B - sterile alpha motif domain containing 4B Gene

Also Known as SMGB; Smaug2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55095

About SAMD4B

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,342,421-39,390,764 (from NCBI)

This gene has 12 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.3) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cerebellar neuron development. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SAMD4B Products (30)

mRNA Protein Name
NM_001303614.2 NP_001290543.1 protein Smaug homolog 2 isoform b
NM_001384565.1 NP_001371494.1 protein Smaug homolog 2 isoform a
NM_001384566.1 NP_001371495.1 protein Smaug homolog 2 isoform a
NM_001384568.1 NP_001371497.1 protein Smaug homolog 2 isoform a
NM_001384569.1 NP_001371498.1 protein Smaug homolog 2 isoform a
NM_001384570.1 NP_001371499.1 protein Smaug homolog 2 isoform a
NM_001384571.1 NP_001371500.1 protein Smaug homolog 2 isoform a
NM_001384573.1 NP_001371502.1 protein Smaug homolog 2 isoform a
NM_001384574.2 NP_001371503.1 protein Smaug homolog 2 isoform a
NM_001384575.1 NP_001371504.1 protein Smaug homolog 2 isoform a
NM_001384576.1 NP_001371505.1 protein Smaug homolog 2 isoform a
NM_001384577.1 NP_001371506.1 protein Smaug homolog 2 isoform a
NM_001384578.1 NP_001371507.1 protein Smaug homolog 2 isoform a
NM_001384580.1 NP_001371509.1 protein Smaug homolog 2 isoform b
NM_001384581.1 NP_001371510.1 protein Smaug homolog 2 isoform b
NM_001384582.1 NP_001371511.1 protein Smaug homolog 2 isoform b
NM_001384583.1 NP_001371512.1 protein Smaug homolog 2 isoform b
NM_001384584.1 NP_001371513.1 protein Smaug homolog 2 isoform b
NM_001384585.1 NP_001371514.1 protein Smaug homolog 2 isoform c
NM_001384586.1 NP_001371515.1 protein Smaug homolog 2 isoform c
NM_001384587.1 NP_001371516.1 protein Smaug homolog 2 isoform c
NM_001384588.1 NP_001371517.1 protein Smaug homolog 2 isoform c
NM_001384589.1 NP_001371518.1 protein Smaug homolog 2 isoform c
NM_001384590.1 NP_001371519.1 protein Smaug homolog 2 isoform c
NM_001384591.1 NP_001371520.1 protein Smaug homolog 2 isoform c
NM_001384592.1 NP_001371521.1 protein Smaug homolog 2 isoform c
NM_001384593.1 NP_001371522.1 protein Smaug homolog 2 isoform c
NM_001384594.1 NP_001371523.1 protein Smaug homolog 2 isoform c
NM_001384595.1 NP_001371524.1 protein Smaug homolog 2 isoform d
NM_018028.4 NP_060498.2 protein Smaug homolog 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAMD4B Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (300 - 357)

  • 0
  • 200
  • 400
  • 600
  • 694 a.a.
Protein Preferred Names Protein Names

protein Smaug homolog 2

  • SAM domain-containing protein 4B

SAMD4B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SAMD4B Q5PRF9 BCL2L10 Homo sapiens Q9HD36
Validated Y2H
32296183
Intra
SAMD4B Q5PRF9 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
SAMD4B Q5PRF9 YWHAZ Homo sapiens P63104
Anti Tag CoIP
28514442
Intra
SAMD4B Q5PRF9 YWHAE Homo sapiens P62258
Anti Tag CoIP
33961781
Intra
SAMD4B Q5PRF9 YWHAE Homo sapiens P62258
Anti Tag CoIP
28514442
Intra
SAMD4B Q5PRF9 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
SAMD4B Q5PRF9 USP53 Homo sapiens Q70EK8
Validated Y2H
32296183
Intra
SAMD4B Q5PRF9 LRRC8E Homo sapiens Q6NSJ5
Validated Y2H
32296183
Intra
SAMD4B Q5PRF9 RSRC2 Homo sapiens Q7L4I2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Protoplasmic Astrocytoma

  • Protoplasmic Astrocytic Tumor

  • Astrocytoma Protoplasmic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12427 SAMD4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SAMD4B RGD RGD:1305597
Felis catus SAMD4B VGNC VGNC:64863
Bos taurus SAMD4B VGNC VGNC:34273
Canis familiaris SAMD4B VGNC VGNC:45853
Mus musculus SAMD4B MGD MGI:2448542
Macaca mulatta SAMD4B VGNC VGNC:77102
Others SAMD4B NCBI