BCL2L10 - BCL2 like 10 Gene

Also Known as Boo; Diva; BCL-B; bcl2-L-10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10017

About BCL2L10

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,109,263-52,112,775 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues and 8 paralogues. Broad expression in skin (RPKM 2.0), kidney (RPKM 1.9) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 Family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with Other members of Bcl-2 protein family including BCL2, BCL2L1/BCL-X(L), and Bax. Overexpression of this gene has been shown to suppress cell Apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating Caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and Caspase 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

BCL2L10 Products (2)

mRNA Protein Name
NM_001306168.1 NP_001293097.1 bcl-2-like protein 10 isoform 1
NM_020396.4 NP_065129.1 bcl-2-like protein 10 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IMP
IMP: Inferred from mutant phenotype
21705382 GOA
enables caspase binding IPI
IPI: Inferred from physical interaction
19255499 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11278245 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
27995898 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
11278245 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11278245 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22498477 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
27995898 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
11278245 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL2L10 Protein Structure

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (49 - 163)

  • 0
  • 100
  • 204 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 10

  • BCL2-like 10 (apoptosis facilitator)

  • anti-apoptotic protein Boo

  • anti-apoptotic protein NrH

  • apoptosis regulator Bcl-B

  • death inducer binding to vBcl-2 and Apaf-1

BCL2L10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BCL2L10 Q9HD36 SAMD4B Homo sapiens Q5PRF9
Y2H Prey Pooling
32296183
Intra
BCL2L10 Q9HD36 SAMD4B Homo sapiens Q5PRF9
Y2H Array
32296183
Intra
BCL2L10 Q9HD36 MGST2 Homo sapiens Q99735
Y2H Prey Pooling
32296183
Intra
BCL2L10 Q9HD36 MGST2 Homo sapiens Q99735
Y2H Array
32296183
Intra
BCL2L10 Q9HD36 TMEM200A Homo sapiens Q86VY9
Y2H Prey Pooling
32296183
Intra
BCL2L10 Q9HD36 TMEM200A Homo sapiens Q86VY9
Y2H Array
32296183
Intra
BCL2L10 Q9HD36 AHCYL1 Homo sapiens O43865
BN-PAGE
27995898
Intra
BCL2L10 Q9HD36 BMF Homo sapiens Q96LC9
Y2H Prey Pooling
32296183
Intra
BCL2L10 Q9HD36 BMF Homo sapiens Q96LC9
Y2H Array
32296183
Intra
BCL2L10 Q9HD36 ITPR1 Homo sapiens Q14643
BN-PAGE
27995898
Intra
BCL2L10 Q9HD36 BAX Homo sapiens Q07812
Anti Tag CoIP
23235460
Intra
BCL2L10 Q9HD36 BAX Homo sapiens Q07812
Anti Tag CoIP
33961781
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
Y2H Array
32296183
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
SPR
23235460
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
DLS
23235460
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
Anti Tag CoIP
33961781
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
Y2H Prey Pooling
32296183
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
CD
23235460
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
X-Ray Diffraction
23235460
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521
GMS
23235460
Intra
BCL2L10 Q9HD36 BCL2L11 Homo sapiens O43521-1
Anti Tag CoIP
23235460
Intra
BCL2L10 Q9HD36 BIK Homo sapiens Q13323
Anti Tag CoIP
23235460
Cross: Cross-species interaction Intra: Intraspecies interaction

BCL2L10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84812 BCL2L10 Antibody (YA4509) IHC-P, ICC/IF, FC, ELISA Human
HY-P84812A BCL2L10 Antibody (YA4509)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150540 Bcl-2-IN-10 / Unkown
HY-RS01424 BCL2L10 Human Pre-designed siRNA Set A / Unkown
HY-RS01425 Bcl2l10 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01426 Bcl2l10 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BCL2L10 VGNC VGNC:84313
Mus musculus BCL2L10 MGD MGI:1330841
Rattus norvegicus BCL2L10 RGD RGD:621015
Others BCL2L10 NCBI