2. Gene
  3. BCL2L10 - BCL2 like 10 Gene

BCL2L10 - BCL2 like 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Boo; Diva; BCL-B; bcl2-L-10

Gene ID: 10017 | Gene type: protein coding

About BCL2L10

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,109,263-52,112,775 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues and 8 paralogues. Broad expression in skin (RPKM 2.0), kidney (RPKM 1.9) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 Family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of Bcl-2 protein family including BCL2, BCL2L1/BCL-X(L), and Bax. Overexpression of this gene has been shown to suppress cell Apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating Caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and Caspase 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

BCL2L10 Products(2)

mRNA Protein Name
NM_001306168.1 NP_001293097.1 bcl-2-like protein 10 isoform 1
NM_020396.4 NP_065129.1 bcl-2-like protein 10 isoform 2

BCL2L10 Protein Structure

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (49 - 163)

  • 0
  • 100
  • 204 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 10

BCL2-like 10 (apoptosis facilitator)

anti-apoptotic protein Boo

anti-apoptotic protein NrH

apoptosis regulator Bcl-B

death inducer binding to vBcl-2 and Apaf-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150540 Bcl-2-IN-10 / Unkown
HY-RS01424 BCL2L10 Human Pre-designed siRNA Set A / Unkown
HY-RS01425 Bcl2l10 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01426 Bcl2l10 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BCL2L10 VGNC VGNC:84313
Mus musculus BCL2L10 MGD MGI:1330841
Rattus norvegicus BCL2L10 RGD RGD:621015