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AHCYL1 - adenosylhomocysteinase like 1 Gene

Also Known as DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10768

About AHCYL1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,984,765-110,023,742 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 81.1), duodenum (RPKM 50.1) and 25 other tissues.

Summary

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

AHCYL1 Products (5)

mRNA	Protein	Name
NM_001242673.2	NP_001229602.1	S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242674.2	NP_001229603.1	S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242675.2	NP_001229604.1	S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242676.2	NP_001229605.1	S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_006621.7	NP_006612.2	S-adenosylhomocysteine hydrolase-like protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16769890	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in angiotensin-activated signaling pathway	IDA IDA: Inferred from direct assay	20584908	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	27995898	GOA
involved in mitochondrion-endoplasmic reticulum membrane tethering	IMP IMP: Inferred from mutant phenotype	27995898	GOA
involved in positive regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	16769890	GOA
involved in regulation of mRNA 3'-end processing	IDA IDA: Inferred from direct assay	19224921	GOA
involved in regulation of monoatomic ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16769890	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	18829453	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	27995898	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AHCYL1 Protein Structure

AdoHcyase

AdoHcyase_NAD

0
100
200
300
400
500
530 a.a.

Protein Preferred Names	Protein Names
S-adenosylhomocysteine hydrolase-like protein 1	DC-expressed AHCY-like molecule

AHCYL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AHCYL1	O43865	ZNF165	Homo sapiens	Q53Z40	Validated Y2H	25416956
Intra	AHCYL1	O43865	ZNF165	Homo sapiens	Q53Z40	Y2H Prey Pooling	25416956
Intra	AHCYL1	O43865	DACH1	Homo sapiens	Q9UI36-2	Validated Y2H	25416956
Intra	AHCYL1	O43865	DACH1	Homo sapiens	Q9UI36-2	Y2H Prey Pooling	32296183
Intra	AHCYL1	O43865	DACH1	Homo sapiens	Q9UI36-2	Validated Y2H	32296183
Intra	AHCYL1	O43865	DACH1	Homo sapiens	Q9UI36-2	Y2H Array	25416956
Intra	AHCYL1	O43865	DACH1	Homo sapiens	Q9UI36-2	Y2H Array	32296183
Intra	AHCYL1	O43865	HBQ1	Homo sapiens	P09105	Y2H Prey Pooling	32296183
Intra	AHCYL1	O43865	HBQ1	Homo sapiens	P09105	Y2H Array	32296183
Intra	AHCYL1	O43865	HBQ1	Homo sapiens	P09105	Validated Y2H	32296183
Intra	AHCYL1	O43865	HBQ1	Homo sapiens	P09105	MAPPIT	32296183
Intra	AHCYL1	O43865	BID	Homo sapiens	P55957-2	Validated Y2H	25416956
Intra	AHCYL1	O43865	BID	Homo sapiens	P55957-2	Y2H Array	25416956
Intra	AHCYL1	O43865	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	AHCYL1	O43865	PLEKHG5	Homo sapiens	O94827-4	Validated Y2H	32296183
Intra	AHCYL1	O43865	SLC23A1	Homo sapiens	Q9UHI7-3	Validated Y2H	32296183
Intra	AHCYL1	O43865	JOSD2	Homo sapiens	Q8TAC2	Validated Y2H	32296183
Intra	AHCYL1	O43865	JOSD2	Homo sapiens	Q8TAC2	Y2H Prey Pooling	32296183
Intra	AHCYL1	O43865	JOSD2	Homo sapiens	Q8TAC2	Y2H Array	32296183
Intra	AHCYL1	O43865	SLC23A1	Homo sapiens	Q9UHI7	Y2H Prey Pooling	25416956
Intra	AHCYL1	O43865	BCL2L10	Homo sapiens	Q9HD36	Anti Bait CoIP	27995898
Intra	AHCYL1	O43865	BCL2L10	Homo sapiens	Q9HD36	Anti Tag CoIP	27995898
Intra	AHCYL1	O43865	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	AHCYL1	O43865	CDKN2C	Homo sapiens	P42773	Y2H Array	31515488
Intra	AHCYL1	O43865	CDKN2C	Homo sapiens	P42773	Y2H Prey Pooling	25416956
Intra	AHCYL1	O43865	CDKN2C	Homo sapiens	P42773	Validated Y2H	25416956
Intra	AHCYL1	O43865	CDKN2C	Homo sapiens	P42773	Validated Y2H	32296183
Intra	AHCYL1	O43865	UACA	Homo sapiens	Q9BZF9	Validated Y2H	32296183
Intra	AHCYL1	O43865	HSPA6	Homo sapiens	P17066	Validated Y2H	32296183
Intra	AHCYL1	O43865	HSPA6	Homo sapiens	P17066	Y2H Array	32296183
Intra	AHCYL1	O43865	HSPA6	Homo sapiens	P17066	Y2H Prey Pooling	32296183
Intra	AHCYL1	O43865	PPL	Homo sapiens	O60437	Y2H Array	25416956
Intra	AHCYL1	O43865	PPL	Homo sapiens	O60437	Validated Y2H	25416956
Intra	AHCYL1	O43865	BID	Homo sapiens	P55957	Validated Y2H	25416956
Intra	AHCYL1	O43865	BID	Homo sapiens	P55957	Y2H Array	25416956
Intra	AHCYL1	O43865	BID	Homo sapiens	P55957	Y2H Prey Pooling	25416956
Intra	AHCYL1	O43865	LRRK2	Homo sapiens	Q5S007	Protein Array	29513927
Intra	AHCYL1	O43865	MAGEA2	Homo sapiens	P43356	Y2H Array	32814053
Intra	AHCYL1	O43865	MAGEA2	Homo sapiens	P43356	Y2H Pooling	32814053
Intra	AHCYL1	O43865	MAGEA2	Homo sapiens	P43356	Validated Y2H	32814053
Intra	AHCYL1	O43865	ZNF165	Homo sapiens	P49910	Validated Y2H	32296183
Intra	AHCYL1	O43865	ZNF165	Homo sapiens	P49910	Y2H Prey Pooling	32296183
Intra	AHCYL1	O43865	ZNF165	Homo sapiens	P49910	Y2H Array	32296183
Intra	AHCYL1	O43865	SOX30	Homo sapiens	O94993	Y2H Array	25416956
Intra	AHCYL1	O43865	GEM	Homo sapiens	P55040	Validated Y2H	32296183
Intra	AHCYL1	O43865	GEM	Homo sapiens	P55040	Y2H Array	25416956
Intra	AHCYL1	O43865	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	AHCYL1	O43865	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	AHCYL1	O43865	PSMD9	Homo sapiens	O00233	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intestinal Impaction
Spinocerebellar Ataxia 29	Spinocerebellar Ataxia Type 29 SCA29 Cnpca Cerebellar Vermis Aplasia Aplasia Of Cerebellar Vermis Acv Cerebellar Ataxia, Congenital Nonprogressive, Autosomal Dominant Spinocerebellar Ataxia 29, Congenital Nonprogressive Congenital Nonprogressive Spinocerebellar Ataxia Autosomal Dominant Congenital Nonprogressive Cerebellar Ataxia Ataxia, Spinocerebellar, Type 29, Congenital Nonprogressive Familial Aplasia Of The Vermis
Cerebral Palsy, Ataxic, Autosomal Recessive	Ataxic Cerebral Palsy Acp Hypotonic Cerebral Palsy Cerebral Palsy Ataxic Cerebral Palsy, Atonic Congenital Cerebral Palsy With Ataxia Ataxic Cerebral Paralysis Ataxia With Cerebral Palsy Cerebral Infantile Diataxia
Spinocerebellar Ataxia, Autosomal Recessive 13	Autosomal Recessive Spinocerebellar Ataxia 13 SCAR13 Autosomal Recessive Congenital Cerebellar Ataxia Due To Mglur1 Deficiency Autosomal Recessive Congenital Cerebellar Ataxia Due To Metabotropic Glutamate Receptor 1 Deficiency Autosomal Recessive Spinocerebellar Ataxia Type 13 Spinocerebellar Ataxia, Autosomal Recessive, 13 Ataxia, Spinocerebellar, Autosomal Recessive, Type 13
Hypogonadotropic Hypogonadism 6 With Or Without Anosmia	HH6 Kallmann Syndrome 6 Kal6 Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia
Gillespie Syndrome	GLSP Aniridia, Cerebellar Ataxia And Mental Deficiency Aniridia Cerebellar Ataxia Mental Deficiency Aniridia, Cerebellar Ataxia, And Mental Retardation Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome Aniridia-Cerebellar Ataxia-Intellectual Disability Aniridia-Cerebellar Ataxia-Mental Deficiency Partial Aniridia-Cerebellar Ataxia-Oligophrenia Aniridia, Cerebellar Ataxia, And Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00477	AHCYL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AHCYL1	VGNC	VGNC:37725
Felis catus	AHCYL1	VGNC	VGNC:80130
Rattus norvegicus	AHCYL1	RGD	RGD:1309768
Mus musculus	AHCYL1	MGD	MGI:2385184
Macaca mulatta	AHCYL1	VGNC	VGNC:81350
Bos taurus	AHCYL1	VGNC	VGNC:25751
Others	AHCYL1	NCBI