AHCYL1 - adenosylhomocysteinase like 1 Gene

Homo sapiens

Also known as DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA

Gene ID: 10768 | Gene type: protein coding

About AHCYL1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,984,765-110,023,742 (from NCBI)

This gene has 6 transcripts (splice variants), 275 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 81.1), duodenum (RPKM 50.1) and 25 other tissues.

Summary

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

AHCYL1 Products(5)

mRNA	Protein	Name
NM_001242673.2	NP_001229602.1	S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242674.2	NP_001229603.1	S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242675.2	NP_001229604.1	S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_001242676.2	NP_001229605.1	S-adenosylhomocysteine hydrolase-like protein 1 isoform b
NM_006621.7	NP_006612.2	S-adenosylhomocysteine hydrolase-like protein 1 isoform a

AHCYL1 Protein Structure

AdoHcyase

AdoHcyase_NAD

0
100
200
300
400
500
530 a.a.

Protein Preferred Names

Protein Names

S-adenosylhomocysteine hydrolase-like protein 1

DC-expressed AHCY-like molecule

Related Diseases

Diseases

Alias

Intestinal Impaction

Spinocerebellar Ataxia 29

Spinocerebellar Ataxia Type 29	SCA29
Cnpca	Cerebellar Vermis Aplasia
Aplasia Of Cerebellar Vermis	Acv
Cerebellar Ataxia, Congenital Nonprogressive, Autosomal Dominant	Spinocerebellar Ataxia 29, Congenital Nonprogressive
Congenital Nonprogressive Spinocerebellar Ataxia	Autosomal Dominant Congenital Nonprogressive Cerebellar Ataxia
Ataxia, Spinocerebellar, Type 29, Congenital Nonprogressive	Familial Aplasia Of The Vermis

Cerebral Palsy, Ataxic, Autosomal Recessive

Ataxic Cerebral Palsy	Acp
Hypotonic Cerebral Palsy	Cerebral Palsy Ataxic
Cerebral Palsy, Atonic	Congenital Cerebral Palsy With Ataxia
Ataxic Cerebral Paralysis	Ataxia With Cerebral Palsy
Cerebral Infantile Diataxia

Spinocerebellar Ataxia, Autosomal Recessive 13

Autosomal Recessive Spinocerebellar Ataxia 13	SCAR13
Autosomal Recessive Congenital Cerebellar Ataxia Due To Mglur1 Deficiency	Autosomal Recessive Congenital Cerebellar Ataxia Due To Metabotropic Glutamate Receptor 1 Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 13	Spinocerebellar Ataxia, Autosomal Recessive, 13
Ataxia, Spinocerebellar, Autosomal Recessive, Type 13

Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

HH6	Kallmann Syndrome 6
Kal6	Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia

Gillespie Syndrome

GLSP	Aniridia, Cerebellar Ataxia And Mental Deficiency
Aniridia Cerebellar Ataxia Mental Deficiency	Aniridia, Cerebellar Ataxia, And Mental Retardation
Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome	Aniridia-Cerebellar Ataxia-Intellectual Disability
Aniridia-Cerebellar Ataxia-Mental Deficiency	Partial Aniridia-Cerebellar Ataxia-Oligophrenia
Aniridia, Cerebellar Ataxia, And Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00477	AHCYL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AHCYL1	VGNC	VGNC:37725
Felis catus	AHCYL1	VGNC	VGNC:80130
Rattus norvegicus	AHCYL1	RGD	RGD:1309768
Mus musculus	AHCYL1	MGD	MGI:2385184
Macaca mulatta	AHCYL1	VGNC	VGNC:81350
Bos taurus	AHCYL1	VGNC	VGNC:25751

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