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Art. -Nr.: HY-150540

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Bcl-2-IN-10

Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research.

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CAS. Nr.: 2773354-28-0
Formel: C₂₂H₂₅N₁₁O₁₂
Molecular Weight:635.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Bcl-2-IN-10 Chemical Structure

CAS. Nr.: 2773354-28-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Bax

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	11.3 μM Compound: 1	Anticancer activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
BT-474	IC₅₀	7.06 μM Compound: 1	Anticancer activity against human BT474 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human BT474 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
CCRF-CEM	IC₅₀	1.26 μM Compound: 1	Anticancer activity against human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
Jurkat E6.1	IC₅₀	1.94 μM Compound: 1	Anticancer activity against human Jurkat E6-1 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human Jurkat E6-1 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]
MDA-MB-231	IC₅₀	17.86 μM Compound: 1	Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay	[PMID: 32156499]

In Vitro

Steroid sulfatase-IN-2 (compound 1, 0-20 μM approximately, 72 h) inhibits different cancer cells with IC₅₀s ranging from 1.26 μM to 17.86 μM^[1].
Steroid sulfatase-IN-2 (1 μM, 5 h) releases up to four molecules of nitric oxide^[1].
Steroid sulfatase-IN-2 (8 μM, 8-72 h) induces leukemia cell CCRF-CEM apoptosis via MAPKs pathways, arrests cell in the G2/M phase, and increases ratio of Bax/Bcl-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

CEM cells
Concentration:

8 μM
Incubation Time:

8, 24, 48 or 72 h
Result:

Induced apoptosis in a time-dependent and dose-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

CEM cells
Concentration:

8 μM
Incubation Time:

8, 24, 48 or 72 h
Result:

Arrested cell in the G2/M phase.

Western Blot Analysis^[1]

Cell Line:

CEM cells
Concentration:

0-8 μM
Incubation Time:

72 h
Result:

Increased the levels of JNK and p38, and the levels of phosphorylated JNK and p38.
Decreased Bcl-2 level in a time- and dose-dependent manner, and increased pro-apoptotic Bax level.

Chemical Information

CAS. Nr. 2773354-28-0
Molecular Weight 635.50
Formel C₂₂H₂₅N₁₁O₁₂
SMILES

O=[N+](C1=CC([N+]([O-])=O)=C(C=C1)O/N=[N+](N2CCC(CC2)CN3CCN(CC3)/N=[N+](OC4=C(C=C(C=C4)[N+]([O-])=O)[N+]([O-])=O)\[O-])\[O-])[O-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xun Ji, et al. Double-component diazeniumdiolate derivatives as anti-cancer agents. Bioorg Med Chem. 2020 Apr 15;28(8):115405. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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