MGST2 - microsomal glutathione S-transferase 2 Gene

Homo sapiens

Also known as GST2; MGST-II

Gene ID: 4258 | Gene type: protein coding

About MGST2

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,665,819-139,754,618 (from NCBI)

This gene has 7 transcripts (splice variants), 158 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 15.9), small intestine (RPKM 13.0) and 25 other tissues.

Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

MGST2 Products(4)

mRNA	Protein	Name
NM_001204366.2	NP_001191295.1	microsomal glutathione S-transferase 2 isoform 1 precursor
NM_001204367.2	NP_001191296.1	microsomal glutathione S-transferase 2 isoform 2
NM_001204368.2	NP_001191297.1	microsomal glutathione S-transferase 2 isoform 3 precursor
NM_002413.5	NP_002404.1	microsomal glutathione S-transferase 2 isoform 1 precursor

MGST2 Protein Structure

MAPEG

0
100
147 a.a.

Protein Preferred Names

Protein Names

microsomal glutathione S-transferase 2

glutathione peroxidase MGST2

Related Diseases

Diseases

Alias

Persistent Mild Asthma

Psoriasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08417	MGST2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MGST2	VGNC	VGNC:68252
Mus musculus	MGST2	MGD	MGI:2448481
Macaca mulatta	MGST2	VGNC	VGNC:74719
Rattus norvegicus	MGST2	RGD	RGD:1311218
Canis familiaris	MGST2	VGNC	VGNC:54328
Bos taurus	MGST2	VGNC	VGNC:31452
Others	MGST2	NCBI

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