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BIK - BCL2 interacting killer Gene

Also Known as BP4; NBK; BIP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 638

About BIK

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,110,750-43,129,712 (from NCBI)

This gene has 1 transcript (splice variant) and 52 orthologues. Biased expression in stomach (RPKM 6.4), colon (RPKM 5.6) and 13 other tissues.

Summary

The protein encoded by this gene shares a critical BH3 domain with Other death-promoting proteins, such as BID, Bak, BAD and Bax, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

BIK Products (1)

mRNA	Protein	Name
NM_001197.5	NP_001188.1	bcl-2-interacting killer

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9027312	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	21041309	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	21041309	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	16697956	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Bcl-2 family protein complex	IPI IPI: Inferred from physical interaction	15694340	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIK Protein Structure

bcl-2I13

0
100
160 a.a.

Protein Preferred Names	Protein Names
bcl-2-interacting killer	BCL2-interacting killer (apoptosis-inducing)

BIK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BIK	Q13323	BCL2A1	Homo sapiens	Q16548	Y2H Array	32296183
Intra	BIK	Q13323	BCL2A1	Homo sapiens	Q16548	Y2H Prey Pooling	25416956
Intra	BIK	Q13323	BCL2A1	Homo sapiens	Q16548	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	BCL2A1	Homo sapiens	Q16548	Validated Y2H	32296183
Intra	BIK	Q13323	BCL2A1	Homo sapiens	Q16548	Y2H Array	25416956
Intra	BIK	Q13323	GRM2	Homo sapiens	Q14416	Validated Y2H	32296183
Intra	BIK	Q13323	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	BIK	Q13323	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	BIK	Q13323	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM199	Homo sapiens	Q8N511	Validated Y2H	32296183
Intra	BIK	Q13323	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	BIK	Q13323	PLPP4	Homo sapiens	Q5VZY2	Validated Y2H	32296183
Intra	BIK	Q13323	SLC39A7	Homo sapiens	Q92504	Validated Y2H	32296183
Intra	BIK	Q13323	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	BIK	Q13323	ADGRE2	Homo sapiens	Q9UHX3	Y2H Array	32296183
Intra	BIK	Q13323	ADGRE2	Homo sapiens	Q9UHX3	Validated Y2H	32296183
Intra	BIK	Q13323	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	BIK	Q13323	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	BIK	Q13323	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	BIK	Q13323	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	TMEM254	Homo sapiens	Q8TBM7	Validated Y2H	32296183
Intra	BIK	Q13323	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	BIK	Q13323	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	BIK	Q13323	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	BIK	Q13323	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	BIK	Q13323	NRAC	Homo sapiens	Q8N912	Validated Y2H	32296183
Intra	BIK	Q13323	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	BIK	Q13323	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	BIK	Q13323	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	BIK	Q13323	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM229B	Homo sapiens	Q8NBD8	Validated Y2H	32296183
Intra	BIK	Q13323	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	BIK	Q13323	CNIH3	Homo sapiens	Q8TBE1	Validated Y2H	32296183
Intra	BIK	Q13323	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	BIK	Q13323	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	BIK	Q13323	SLC35A4	Homo sapiens	Q96G79	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM107	Homo sapiens	Q6UX40	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	BIK	Q13323	SLC35E3	Homo sapiens	Q7Z769	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	SLC35E3	Homo sapiens	Q7Z769	Validated Y2H	32296183
Intra	BIK	Q13323	SLC35E3	Homo sapiens	Q7Z769	Y2H Array	32296183
Intra	BIK	Q13323	EXOC3L2	Homo sapiens	Q2M3D2	Validated Y2H	32296183
Intra	BIK	Q13323	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	BIK	Q13323	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	BIK	Q13323	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	BIK	Q13323	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	BIK	Q13323	BCL2L10	Homo sapiens	Q9HD36	Y2H Array	32296183
Intra	BIK	Q13323	BCL2L10	Homo sapiens	Q9HD36	Validated Y2H	32296183
Intra	BIK	Q13323	BCL2L10	Homo sapiens	Q9HD36	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	BCL2L10	Homo sapiens	Q9HD36	Complementation	32296183
Intra	BIK	Q13323	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	BIK	Q13323	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	BIK	Q13323	MARCHF5	Homo sapiens	Q9NX47	Y2H Array	32296183
Intra	BIK	Q13323	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	BIK	Q13323	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	BIK	Q13323	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	BIK	Q13323	TMBIM1	Homo sapiens	Q969X1	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	BIK	Q13323	NAT8	Homo sapiens	Q9UHE5	Validated Y2H	32296183
Intra	BIK	Q13323	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183
Intra	BIK	Q13323	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	BCL2L1	Homo sapiens	Q07817-1	SPR	15694340
Intra	BIK	Q13323	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	BIK	Q13323	KCNN4	Homo sapiens	O15554	Y2H Array	32296183
Intra	BIK	Q13323	KCNN4	Homo sapiens	O15554	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	TMEM222	Homo sapiens	Q9H0R3	Validated Y2H	32296183
Intra	BIK	Q13323	ALG8	Homo sapiens	Q9BVK2	Validated Y2H	32296183
Intra	BIK	Q13323	SCAMP4	Homo sapiens	Q969E2	Validated Y2H	32296183
Intra	BIK	Q13323	VKORC1	Homo sapiens	Q9BQB6	Validated Y2H	32296183
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	BFG-2H	27107012
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	Y2H Prey Pooling	25416956
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	Complementation	32296183
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	Validated Y2H	25416956
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	Y2H Array	25416956
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	SPR	15694340
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	Y2H Array	32296183
Intra	BIK	Q13323	BCL2L2	Homo sapiens	Q92843	FPS	16697956
Intra	BIK	Q13323	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	BIK	Q13323	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM120A	Homo sapiens	Q9BXJ8	Validated Y2H	32296183
Intra	BIK	Q13323	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	BIK	Q13323	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	FATE1	Homo sapiens	Q969F0	Y2H	21516116
Intra	BIK	Q13323	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	BIK	Q13323	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	BIK	Q13323	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
Intra	BIK	Q13323	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	BIK	Q13323	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	BIK	Q13323	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	BCL2	Homo sapiens	P10415	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	BCL2	Homo sapiens	P10415	Anti Tag CoIP	17289999
Intra	BIK	Q13323	BCL2	Homo sapiens	P10415	Y2H Array	32296183
Intra	BIK	Q13323	BCL2L1	Homo sapiens	Q07817	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	BCL2L1	Homo sapiens	Q07817	BFG-2H	27107012
Intra	BIK	Q13323	BCL2L1	Homo sapiens	Q07817	Y2H Array	32296183
Intra	BIK	Q13323	BCL2L1	Homo sapiens	Q07817	FPS	16697956
Intra	BIK	Q13323	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	BIK	Q13323	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	BIK	Q13323	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	BIK	Q13323	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	BIK	Q13323	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	BIK	Q13323	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	BIK	Q13323	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
Intra	BIK	Q13323	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	BIK	Q13323	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hyperinsulinemic Hypoglycemia, Familial, 1	HHF1 Persistent Hyperinsulinemic Hypoglycemia Of Infancy Familial Hyperinsulinemic Hypoglycemia 1 Congenital Hyperinsulinism Phhi Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency Hypoglycemia, Hyperinsulinemic, Of Infancy Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia Nesidioblastosis Of Pancreas Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis Hyperinsulinism, Congenital Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50868	Bafetinib		99.18%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5341	Bik BH3		/	Unkown
HY-E70861	SIK1 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS01503	BIK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17788	Bik Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24255	Bik Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BIK	RGD	RGD:621547
Mus musculus	BIK	MGD	MGI:1206591
Canis familiaris	BIK	VGNC	VGNC:38457
Macaca mulatta	BIK	VGNC	VGNC:107772
Others	BIK	NCBI