KCNN4 - potassium calcium-activated channel subfamily N member 4 Gene

Also Known as IK; IK1; SK4; DHS2; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3783

About KCNN4

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:43,766,533-43,780,973 (from NCBI)

This gene has 9 transcripts (splice variants), 190 orthologues, 3 paralogues and is associated with 3 phenotypes. Biased expression in salivary gland (RPKM 25.8), stomach (RPKM 13.6) and 10 other tissues.

Summary

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent Potassium Channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated Potassium Channel in T-lymphocytes. This gene is similar to Other KCNN family Potassium Channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

KCNN4 Products (1)

mRNA	Protein	Name
NM_002250.3	NP_002241.1	intermediate conductance calcium-activated potassium channel protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	18796614	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	29724949	GOA
enables intermediate conductance calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	9326665	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10880439	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29953543	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	18796614	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion transport	IDA IDA: Inferred from direct assay	18796614	GOA
involved in macropinocytosis	IDA IDA: Inferred from direct assay	24591580	GOA
involved in positive regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	18796614	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	9326665	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	29724949	GOA
involved in regulation of calcium ion import across plasma membrane	IDA IDA: Inferred from direct assay	17157250	GOA
involved in stabilization of membrane potential	IDA IDA: Inferred from direct assay	18796614	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	15831468	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	24591580	GOA
located in vesicle	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNN4 Protein Structure

SK_channel

Ion_trans_2

CaMBD

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
intermediate conductance calcium-activated potassium channel protein 4	SKCa 4

KCNN4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCNN4	O15554	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	KCNN4	O15554	CNIH3	Homo sapiens	Q8TBE1	Validated Y2H	32296183
Intra	KCNN4	O15554	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	KCNN4	O15554	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	KCNN4	O15554	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	KCNN4	O15554	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	KCNN4	O15554	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	KCNN4	O15554	PHPT1	Homo sapiens	Q9NRX4	Anti Tag CoIP	18796614
Intra	KCNN4	O15554	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	KCNN4	O15554	STX1B	Homo sapiens	P61266	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KCNN4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83836	KCNN4 Antibody (YA3533)	WB, ICC/IF, FC, ELISA	Human
HY-P83836A	KCNN4 Antibody (YA3533)(PBS only)	WB, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Dehydrated Hereditary Stomatocytosis 2	Xerocytosis Gardos Desiccytosis Gardos DHS2
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema	Dehydrated Hereditary Stomatocytosis Hereditary Xerocytosis Xerocytosis, Hereditary Pshk1 Pseudohyperkalemia Edinburgh Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema DHS1 Dhs Hereditary Desiccytosis Dehydrated Hereditary Stomatocytosis 1 Desiccytosis, Hereditary Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak Pseudohyperkalemia Familial 1, Due To Red Cell Leak Desiccytosis Hereditary Xerocytosis Hereditary Familial Pseudohyperkalemia 1 Due To Red Cell Leak Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema Xerocytosis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Hereditary Stomatocytosis	Hereditary Stomatocytic Disease
Sickle Cell Disease	Hbs Disease Hemoglobin S Disease Scd Sickle Cell Disorders Sickling Disorder Due To Hemoglobin S Anemia, Sickle Cell Hb-Ss Disease Without Crisis Hbss Without Crisis Sickle-Cell Anaemia Without Crisis Scd - [Sickle Cell Disease] Sca - [Sickle Cell Anaemia] Sickle Cell Disease Nos Sickle Cell Disorder Sickle Cell Syndrome Sickle-Cell Anaemia Nos Sickle-Cell Disorder Nos Haemoglobin S Disease Haemoglobin Ss Disease Hb S Disease Hb Ss Disease Herrick Anaemia Hereditary Haemoglobinopathy Disorder Homozygous For Haemoglobin S Sickle-Cell Haemoglobin Disease Sickling Disorder Due To Haemoglobin S Hb-Ss Disease With Crisis Sickle Cell Crisis Sickle-Cell Disorder With Crisis Sickle-Cell Anaemia With Crisis Hbss With Crisis Hb S Disease With Mention Of Crisis Haemoglobin Ss Disease With Crisis Hb-Ss Disease With Vaso-Occlusive Pain Vaso-Occlusive Crisis
Fabry Disease	Alpha-Galactosidase A Deficiency Anderson-Fabry Disease Angiokeratoma Corporis Diffusum Ceramide Trihexosidase Deficiency Fabry Disease, Cardiac Variant Fabry'S Disease Hereditary Dystopic Lipidosis Gla Deficiency FD Alpha Galactosidase Deficiency Deficiency Of Melibiase Angiokeratoma, Diffuse Angiokeratoma Diffuse Diffuse Angiokeratoma
Erythroleukemia
Anemia, Congenital Dyserythropoietic, Type Ia	Congenital Dyserythropoietic Anemia Type I Cda I CDAN1A Congenital Dyserythropoietic Anemia Type 1 Congenital Dyserythropoietic Anemia Type Ia Congenital Dyserythropoietic Anemia, Type I Anemia, Congenital Dyserythropoietic, Type I Cda Type 1 Cda Type I Cda Ia Dyserythropoietic Anemia, Congenital Type 1 Anemia, Congenital Dyserythropoietic, Type 1a Dyserythropoietic Anemia, Congenital, Type Ia Cda, Type Ia Congenital Dyserythropoietic Anaemia Type 1 Congenital Dyserythropoietic Anaemia Type I Anemia, Dyserythropoietic, Congenital Type 1 Type I Congenital Dyserythropoietic Anemia Anemia, Congenital Dyserythropoietic, 1a Anemia, Dyserythropoietic, Congenital, Type Ia
Anemia, Congenital Dyserythropoietic, Type Ib	CDAN1B Congenital Dyserythropoietic Anemia Type Ib Cda, Type Ib Congenital Dyserythropoietic Anemia Type Type 1b Dyserythropoietic Anemia, Congenital, Type Ib Anemia, Congenital Dyserythropoietic, 1b Cda Ib Anemia, Dyserythropoietic, Congenital Anemia, Dyserythropoietic, Congenital, Type Ib
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Robinow Syndrome, Autosomal Dominant 2	Autosomal Dominant Robinow Syndrome 2 DRS2 Robinow, Autosomal Dominant Syndrome, Type 2
Anemia, Congenital Dyserythropoietic, Type Iv	CDAN4 Congenital Dyserythropoietic Anemia Type Iv Congenital Dyserythropoietic Anemia Type 4 Cda Iv Cda Due To Klf1 Mutation Cda Type 4 Cda Type Iv Congenital Dyserythropoietic Anemia Due To Klf1 Mutation Cda, Type Iv Dyserythropoietic Anemia, Congenital, Type Iv Congenital Dyserythropoietic Anaemia Due To Klf1 Mutation Congenital Dyserythropoietic Anaemia Type 4 Congenital Dyserythropoietic Anaemia Type Iv Anemia, Congenital Dyserythropoietic, 4 Anemia, Dyserythropoietic Congenital, Type Iv Anemia, Dyserythropoietic, Congenital, Type Iv
Anemia, Congenital Dyserythropoietic, Type Ii	Congenital Dyserythropoietic Anemia Type Ii CDAN2 Cda Ii Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test Cda Type Ii Congenital Dyserythropoietic Anemia Type 2 Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test Sec23b-Cdg Congenital Dyserythropoietic Anemia, Type Ii Dyserythropoietic Anemia, Hempas Type Hempas Cda Type 2 Dyserythropoietic Anemia, Congenital, Type Ii Cda, Type Ii Congenital Dyserythropoietic Anaemia Type 2 Congenital Dyserythropoietic Anaemia Type Ii Anemia, Dyserythropoietic, Congenital Type 2 Hempas Anemia Dyserythropoietic Anemia, Congenital Type 2 Anemia, Congenital Dyserythropoietic, 2 Dyserythropoietic Anemia Hempas Type Anemia, Dyserythropoietic Congenital, Type Ii Anemia, Dyserythropoietic, Congenital, Type Ii
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Hereditary Elliptocytosis	Congenital Elliptocytosis Ovalocytosis Elliptocytosis, Hereditary He Elliptocytosis Hereditary Congenital Ovalocytosis Elliptocytosis Hereditary Elliptocytosis With Infantile Poikilocytosis Hereditary Ovalocytosis Oval Erythrocytosis He - [Hereditary Elliptocytosis] Elliptocytosis Anaemia
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4121	L17E		99.88%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W403607	CBIQ	Activator	99.94%	Unkown
HY-RS07172	KCNN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20432	Kcnn4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26941	Kcnn4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KCNN4	VGNC	VGNC:30486
Felis catus	KCNN4	VGNC	VGNC:67928
Canis familiaris	KCNN4	VGNC	VGNC:42287
Mus musculus	KCNN4	MGD	MGI:1277957
Rattus norvegicus	KCNN4	RGD	RGD:621476
Others	KCNN4	NCBI