2. Membrane Transporter/Ion Channel
  3. Chloride Channel Potassium Channel
  4. CBIQ

CBIQ  (Synonyms: 4-Chlorobenzo[f]isoquinoline)

Cat. No.: HY-W403607 Purity: 99.94%
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CBIQ (4-Chlorobenzo[f]isoquinoline) is a benzoisoquinoline compound. CBIQ can activate the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- ion channels and the intermediate-conductance calcium-sensitive K+ channel (KCNN4) with Kd values of 0.1 and 3.9 μM. CBIQ can be used for the research related to cystic fibrosis.

For research use only. We do not sell to patients.

CBIQ

CBIQ Chemical Structure

CAS No. : 32081-28-0

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CBIQ Related Antibodies

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Description

CBIQ (4-Chlorobenzo[f]isoquinoline) is a benzoisoquinoline compound. CBIQ can activate the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- ion channels and the intermediate-conductance calcium-sensitive K+ channel (KCNN4) with Kd values of 0.1 and 3.9 μM. CBIQ can be used for the research related to cystic fibrosis[1].

Molecular Weight

213.66

Formula

C13H8ClN
CAS No.
Appearance

Solid

SMILES

ClC1=NC=CC2=C1C=CC=3C=CC=CC32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (146.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6803 mL 23.4017 mL 46.8033 mL
5 mM 0.9361 mL 4.6803 mL 9.3607 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6803 mL 23.4017 mL 46.8033 mL 117.0083 mL
5 mM 0.9361 mL 4.6803 mL 9.3607 mL 23.4017 mL
10 mM 0.4680 mL 2.3402 mL 4.6803 mL 11.7008 mL
15 mM 0.3120 mL 1.5601 mL 3.1202 mL 7.8006 mL
20 mM 0.2340 mL 1.1701 mL 2.3402 mL 5.8504 mL
25 mM 0.1872 mL 0.9361 mL 1.8721 mL 4.6803 mL
30 mM 0.1560 mL 0.7801 mL 1.5601 mL 3.9003 mL
40 mM 0.1170 mL 0.5850 mL 1.1701 mL 2.9252 mL
50 mM 0.0936 mL 0.4680 mL 0.9361 mL 2.3402 mL
60 mM 0.0780 mL 0.3900 mL 0.7801 mL 1.9501 mL
80 mM 0.0585 mL 0.2925 mL 0.5850 mL 1.4626 mL
100 mM 0.0468 mL 0.2340 mL 0.4680 mL 1.1701 mL
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CBIQ Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBIQ32081-28-04-Chlorobenzo[f]isoquinolineChloride ChannelPotassium ChannelCl− Channels KcsAInhibitorinhibitorinhibit

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