CNIH3 - cornichon family AMPA receptor auxiliary protein 3 Gene

Also Known as CNIH-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 149111

About CNIH3

This gene has 14 transcripts (splice variants), 194 orthologues and 4 paralogues. Biased expression in brain (RPKM 4.8), testis (RPKM 1.6) and 10 other tissues.

Summary

Predicted to enable channel regulator activity. Involved in regulation of AMPA Receptor activity. Predicted to be located in dendritic shaft and postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendrite and glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

CNIH3 Products (5)

mRNA Protein Name
NM_001322302.2 NP_001309231.1 protein cornichon homolog 3 isoform 2
NM_001322303.2 NP_001309232.1 protein cornichon homolog 3 isoform 3
NM_001322304.2 NP_001309233.1 protein cornichon homolog 3 isoform 4
NM_001322305.2 NP_001309234.1 protein cornichon homolog 3 isoform 5
NM_152495.2 NP_689708.1 protein cornichon homolog 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
20805473 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNIH3 Protein Structure

Cornichon

Cornichon: Cornichon protein (1 - 48)

Cornichon

Cornichon: Cornichon protein (59 - 152)

  • 0
  • 100
  • 160 a.a.
Protein Preferred Names Protein Names

protein cornichon homolog 3

  • cornichon homolog 3

CNIH3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNIH3 Q8TBE1 SORT1 Homo sapiens Q99523
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 SORT1 Homo sapiens Q99523
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 SORT1 Homo sapiens Q99523
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 CEACAM3 Homo sapiens P40198
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 CEACAM3 Homo sapiens P40198
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 SUSD3 Homo sapiens Q96L08
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 CLDN20 Homo sapiens P56880
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 CLDN20 Homo sapiens P56880
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 PLD3 Homo sapiens Q8IV08
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 PLD3 Homo sapiens Q8IV08
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 KCNN4 Homo sapiens O15554
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 KCNN4 Homo sapiens O15554
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 SMIM3 Homo sapiens Q9BZL3
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 SMIM3 Homo sapiens Q9BZL3
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
CNIH3 Q8TBE1 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
CNIH3 Q8TBE1 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
CNIH3 Q8TBE1 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
CNIH3 Q8TBE1 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
CNIH3 Q8TBE1 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
CNIH3 Q8TBE1 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Splenic Artery Aneurysm

  • Aneurysm Of Splenic Artery
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02886 CNIH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27407 Cnih2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CNIH3 VGNC VGNC:39401
Macaca mulatta CNIH3 VGNC VGNC:71359
Felis catus CNIH3 VGNC VGNC:107860
Rattus norvegicus CNIH3 RGD RGD:1582859
Mus musculus CNIH3 MGD MGI:1920228
Bos taurus CNIH3 VGNC VGNC:27503
Others CNIH3 NCBI