NRM - nurim Gene

Also Known as NRM29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11270

About NRM

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,688,049-30,691,420 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 182 orthologues. Ubiquitous expression in skin (RPKM 5.3), bone marrow (RPKM 5.1) and 25 other tissues.

Summary

The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase Enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

NRM Products (6)

mRNA Protein Name
NM_001270707.2 NP_001257636.1 nurim isoform 2
NM_001270708.2 NP_001257637.1 nurim isoform 3
NM_001270709.2 NP_001257638.1 nurim isoform 4
NM_001270710.2 NP_001257639.1 nurim isoform 5
NM_001384369.1 NP_001371298.1 nurim isoform 1
NM_007243.3 NP_009174.1 nurim isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
10402458 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRM Protein Structure

NnrU

NnrU: NnrU protein (69 - 201)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

nurim

  • nuclear rim protein

NRM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NRM Q8IXM6 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
NRM Q8IXM6 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 TRIM59 Homo sapiens Q8IWR1
Y2H Array
32296183
Intra
NRM Q8IXM6 TRIM59 Homo sapiens Q8IWR1
Y2H Array
31515488
Intra
NRM Q8IXM6 TRIM59 Homo sapiens Q8IWR1
Validated Y2H
25416956
Intra
NRM Q8IXM6 TRIM59 Homo sapiens Q8IWR1
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SUN2 Homo sapiens Q9UH99
Validated Y2H
25416956
Intra
NRM Q8IXM6 SUN2 Homo sapiens Q9UH99
Y2H Array
25416956
Intra
NRM Q8IXM6 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
NRM Q8IXM6 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 RMDN3 Homo sapiens Q96TC7
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 RMDN3 Homo sapiens Q96TC7
Validated Y2H
32296183
Intra
NRM Q8IXM6 RMDN3 Homo sapiens Q96TC7
Y2H Array
32296183
Intra
NRM Q8IXM6 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
NRM Q8IXM6 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra
NRM Q8IXM6 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
NRM Q8IXM6 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC6A15 Homo sapiens Q9H2J7
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC6A15 Homo sapiens Q9H2J7
Validated Y2H
32296183
Intra
NRM Q8IXM6 SLC6A15 Homo sapiens Q9H2J7
Y2H Array
32296183
Intra
NRM Q8IXM6 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
NRM Q8IXM6 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
NRM Q8IXM6 GPR151 Homo sapiens Q8TDV0
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 GPR151 Homo sapiens Q8TDV0
Validated Y2H
32296183
Intra
NRM Q8IXM6 GPR151 Homo sapiens Q8TDV0
Y2H Array
32296183
Intra
NRM Q8IXM6 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
NRM Q8IXM6 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
NRM Q8IXM6 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 RTP4 Homo sapiens Q96DX8
Y2H Array
32296183
Intra
NRM Q8IXM6 RTP4 Homo sapiens Q96DX8
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 RTP4 Homo sapiens Q96DX8
Validated Y2H
32296183
Intra
NRM Q8IXM6 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
NRM Q8IXM6 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
NRM Q8IXM6 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
NRM Q8IXM6 PCDHGA4 Homo sapiens Q9Y5G9
Validated Y2H
32296183
Intra
NRM Q8IXM6 PCDHGA4 Homo sapiens Q9Y5G9
Y2H Array
32296183
Intra
NRM Q8IXM6 PCDHGA4 Homo sapiens Q9Y5G9
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
NRM Q8IXM6 OPN1LW Homo sapiens P04000
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 OPN1LW Homo sapiens P04000
Y2H Array
32296183
Intra
NRM Q8IXM6 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra
NRM Q8IXM6 CLRN1 Homo sapiens P58418
Y2H Array
32296183
Intra
NRM Q8IXM6 CLRN1 Homo sapiens P58418
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
NRM Q8IXM6 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
NRM Q8IXM6 PARP15 Homo sapiens Q460N3-2
Y2H Array
32296183
Intra
NRM Q8IXM6 PARP15 Homo sapiens Q460N3-2
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
NRM Q8IXM6 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
NRM Q8IXM6 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
NRM Q8IXM6 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
NRM Q8IXM6 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
NRM Q8IXM6 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
NRM Q8IXM6 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC10A2 Homo sapiens Q12908
Y2H Array
32296183
Intra
NRM Q8IXM6 SLC10A2 Homo sapiens Q12908
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
NRM Q8IXM6 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
NRM Q8IXM6 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
NRM Q8IXM6 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 RNASEH1 Homo sapiens O60930
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 RNASEH1 Homo sapiens O60930
Y2H Array
32296183
Intra
NRM Q8IXM6 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
NRM Q8IXM6 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
Intra
NRM Q8IXM6 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
NRM Q8IXM6 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 CNR2 Homo sapiens P34972
Y2H Array
32296183
Intra
NRM Q8IXM6 HHLA2 Homo sapiens Q9UM44
Validated Y2H
32296183
Intra
NRM Q8IXM6 HHLA2 Homo sapiens Q9UM44
Y2H Array
32296183
Intra
NRM Q8IXM6 HHLA2 Homo sapiens Q9UM44
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 HDAC11 Homo sapiens Q96DB2
Validated Y2H
32296183
Intra
NRM Q8IXM6 HDAC11 Homo sapiens Q96DB2
Y2H Array
32296183
Intra
NRM Q8IXM6 HDAC11 Homo sapiens Q96DB2
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 ATP6V0B Homo sapiens Q99437
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 ATP6V0B Homo sapiens Q99437
Validated Y2H
32296183
Intra
NRM Q8IXM6 ATP6V0B Homo sapiens Q99437
Y2H Array
32296183
Intra
NRM Q8IXM6 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
NRM Q8IXM6 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
NRM Q8IXM6 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
NRM Q8IXM6 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
NRM Q8IXM6 AGR3 Homo sapiens Q8TD06
Y2H Array
32296183
Intra
NRM Q8IXM6 AGR3 Homo sapiens Q8TD06
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 AGR3 Homo sapiens Q8TD06
Validated Y2H
32296183
Intra
NRM Q8IXM6 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra
NRM Q8IXM6 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
NRM Q8IXM6 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
NRM Q8IXM6 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
NRM Q8IXM6 FRMD3 Homo sapiens A2A2Y4
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 FRMD3 Homo sapiens A2A2Y4
Y2H Array
32296183
Intra
NRM Q8IXM6 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
NRM Q8IXM6 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
NRM Q8IXM6 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
NRM Q8IXM6 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra
NRM Q8IXM6 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
NRM Q8IXM6 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
NRM Q8IXM6 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
NRM Q8IXM6 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra
NRM Q8IXM6 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
32296183
Intra
NRM Q8IXM6 ANK1 Homo sapiens P16157-17
Y2H Array
32296183
Intra
NRM Q8IXM6 ANK1 Homo sapiens P16157-17
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 ERP29 Homo sapiens P30040
Y2H Prey Pooling
32296183
Intra
NRM Q8IXM6 ERP29 Homo sapiens P30040
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 20

  • Amyotrophic Lateral Sclerosis Type 20

  • ALS20

  • Sclerosis, Lateral, Amyotrophic, Type 20
Amyotrophic Lateral Sclerosis Type 5

  • Amyotrophic Lateral Sclerosis 5

  • Als5
Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia

  • Amyotrophic Lateral Sclerosis Type 10

  • ALS10

  • Amyotrophic Lateral Sclerosis 10, With Or Without Ftd

  • Frontotemporal Lobar Degeneration, Tardbp-Related

  • Amyotrophic Lateral Sclerosis 10

  • Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia

  • Tardbp-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions

  • Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia And With Tdp43 Inclusions

  • Sclerosis, Lateral, Amyotrophic, Type Type 10
Acatalasemia

  • Acatalasia

  • Catalase Deficiency

  • Deficiency Of Catalase

  • ACATLAS

  • Takahara'S Disease

  • Takahara Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-121404A Muscarine chloride Agonist 99.9% Unkown
HY-107654 Muscarine iodide Agonist 99.55% Unkown
HY-107042 trans-Sobrerol Inhibitor 99.75% Unkown
HY-108289 Sobrerol / Unkown
HY-121404 Muscarine Agonist / Unkown
HY-RS09576 NRM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18455 Nrm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24936 Nrm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NRM VGNC VGNC:49560
Rattus norvegicus NRM RGD RGD:1302966
Macaca mulatta NRM VGNC VGNC:75531
Felis catus NRM VGNC VGNC:68568
Mus musculus NRM MGD MGI:2146855
Others NRM NCBI