country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

MRM1 - mitochondrial rRNA methyltransferase 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79922

About MRM1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,601,583-36,634,698 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 189 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 1.2), lymph node (RPKM 1.0) and 25 other tissues.

Summary

Enables rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA 2'-O-methylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MRM1 Products (1)

mRNA	Protein	Name
NM_024864.5	NP_079140.2	rRNA methyltransferase 1, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables rRNA (guanosine-2'-O-)-methyltransferase activity	EXP EXP: Inferred from Experiment	25074936	GOA
enables rRNA (guanosine-2'-O-)-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	35177605	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	27184847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRM1 Protein Structure

SpoU_sub_bind

SpoU_methylase

0
100
200
300
353 a.a.

Protein Preferred Names	Protein Names
rRNA methyltransferase 1, mitochondrial	16S rRNA (guanosine(1145)-2'-O)-methyltransferase

MRM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MRM1	Q6IN84	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	MRM1	Q6IN84	CCL4L1	Homo sapiens	Q8NHW4	Validated Y2H	32296183
Intra	MRM1	Q6IN84	VKORC1L1	Homo sapiens	Q8N0U8	Validated Y2H	32296183
Intra	MRM1	Q6IN84	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	MRM1	Q6IN84	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	MRM1	Q6IN84	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	MRM1	Q6IN84	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	MRM1	Q6IN84	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	MRM1	Q6IN84	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	MRM1	Q6IN84	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	MRM1	Q6IN84	VSTM1	Homo sapiens	Q6UX27-3	Validated Y2H	32296183
Intra	MRM1	Q6IN84	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	MRM1	Q6IN84	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	MRM1	Q6IN84	SYT3	Homo sapiens	Q9BQG1	Validated Y2H	32296183
Intra	MRM1	Q6IN84	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	MRM1	Q6IN84	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	MRM1	Q6IN84	RHBDD2	Homo sapiens	Q6NTF9-3	Validated Y2H	32296183
Intra	MRM1	Q6IN84	NXPE3	Homo sapiens	Q969Y0	Validated Y2H	32296183
Intra	MRM1	Q6IN84	SPX	Homo sapiens	Q9BT56	Validated Y2H	32296183
Intra	MRM1	Q6IN84	ITGAM	Homo sapiens	P11215	Y2H Prey Pooling	32296183
Intra	MRM1	Q6IN84	AQP3	Homo sapiens	Q92482	Validated Y2H	32296183
Intra	MRM1	Q6IN84	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	MRM1	Q6IN84	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	MRM1	Q6IN84	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	MRM1	Q6IN84	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	MRM1	Q6IN84	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	MRM1	Q6IN84	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	MRM1	Q6IN84	CGGBP1	Homo sapiens	Q9UFW8	Anti Tag CoIP	28514442
Intra	MRM1	Q6IN84	CGGBP1	Homo sapiens	Q9UFW8	Anti Tag CoIP	33961781
Intra	MRM1	Q6IN84	CGGBP1	Homo sapiens	Q9UFW8	Validated Y2H	32296183
Intra	MRM1	Q6IN84	CMTM3	Homo sapiens	Q96MX0	Validated Y2H	32296183
Intra	MRM1	Q6IN84	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	MRM1	Q6IN84	COQ8A	Homo sapiens	Q8NI60	Validated Y2H	32296183
Intra	MRM1	Q6IN84	KLRG1	Homo sapiens	Q96E93	Validated Y2H	32296183
Intra	MRM1	Q6IN84	DNAJC30	Homo sapiens	Q96LL9	Validated Y2H	32296183
Intra	MRM1	Q6IN84	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183
Intra	MRM1	Q6IN84	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	MRM1	Q6IN84	MAL2	Homo sapiens	Q969L2	Y2H Prey Pooling	32296183
Intra	MRM1	Q6IN84	MAL2	Homo sapiens	Q969L2	Validated Y2H	32296183
Intra	MRM1	Q6IN84	MAL2	Homo sapiens	Q969L2	Y2H Array	32296183
Intra	MRM1	Q6IN84	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Non-Syndromic X-Linked Intellectual Disability 9	Mrx44 Mrx9 X-Linked Mental Retardation 44
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency	MCC1D Mccd Type 1 Mcc1 Deficiency Methylcrotonylglycinuria Type I 3-Methylcrotonylglycinuria I 3-Methylcrotonoyl-Coa Carboxylase 1 Deficiency 3-Methylcrotonylglycinuria Type I Mcgi 3 Methylcrotonyl-Coa Carboxylase 1 Deficiency 3-Methylcrotonyl Coa Carboxylase 1 Deficiency
Raynaud-Claes Syndrome	Mrx49 MRXSRC Mental Retardation, X-Linked 49 Mrx15 Clcn4-Related X-Linked Intellectual Disability Syndrome Mental Retardation, X-Linked 15 X-Linked Mental Retardation 15 X-Linked Mental Retardation 49 Mental Retardation, X-Linked-49
Mitochondrial Dna Depletion Syndrome 4b	Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Mngie Syndrome Thymidine Phosphorylase Deficiency MTDPS4B Mitochondrial Neurogastrointestinal Encephalopathy Disease Mngie Myoneurogastrointestinal Encephalopathy Syndrome Ogimd Oculogastrointestinal Muscular Dystrophy Polip Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudo-Obstruction Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Polg-Related Mngie, Polg-Related Mepop Mitochondrial Myopathy With Sensorimotor Polyneuropathy, Ophthalmoplegia, And Pseudo-Obstruction Mngie Disease Mitochondrial Dna Depletion Syndrome 4b Mngie Type Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Polg-Related Mngie Polg-Related Mitochondrial Dna Depletion Syndrome, Type 4b Visceral Myopathy Familial External Ophthalmoplegia
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 2 PKD2 Polycystic Kidney Disease, Adult, Type Ii Apkd2 Polycystic Kidney Disease, Type 2 Adpkd2 Adult Polycystic Kidney Disease Type 2 Autosomal Dominant Polycystic Kidney Disease 2 Pkd-2 Polycystic Kidney Disease Adult Type Ii Polycystic Kidney Type 2 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 2
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08655	MRM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22240	Mrm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28762	Mrm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MRM1	VGNC	VGNC:31605
Felis catus	MRM1	VGNC	VGNC:63582
Rattus norvegicus	MRM1	RGD	RGD:1566232
Mus musculus	MRM1	MGD	MGI:2443470
Macaca mulatta	MRM1	VGNC	VGNC:74833
Canis familiaris	MRM1	VGNC	VGNC:43366
Others	MRM1	NCBI