MRM1 - mitochondrial rRNA methyltransferase 1 Gene

Homo sapiens

Gene ID: 79922 | Gene type: protein coding

About MRM1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,601,583-36,634,698 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 189 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 1.2), lymph node (RPKM 1.0) and 25 other tissues.

Summary

Enables rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA 2'-O-methylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MRM1 Products(1)

mRNA	Protein	Name
NM_024864.5	NP_079140.2	rRNA methyltransferase 1, mitochondrial precursor

MRM1 Protein Structure

SpoU_sub_bind

SpoU_methylase

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

rRNA methyltransferase 1, mitochondrial

16S rRNA (guanosine(1145)-2'-O)-methyltransferase

Related Diseases

Diseases

Alias

Non-Syndromic X-Linked Intellectual Disability 9

Mrx44	Mrx9
X-Linked Mental Retardation 44

3-Methylcrotonyl-Coa Carboxylase 1 Deficiency

MCC1D	Mccd Type 1
Mcc1 Deficiency	Methylcrotonylglycinuria Type I
3-Methylcrotonylglycinuria I	3-Methylcrotonoyl-Coa Carboxylase 1 Deficiency
3-Methylcrotonylglycinuria Type I	Mcgi
3 Methylcrotonyl-Coa Carboxylase 1 Deficiency	3-Methylcrotonyl Coa Carboxylase 1 Deficiency

Raynaud-Claes Syndrome

Mrx49	MRXSRC
Mental Retardation, X-Linked 49	Mrx15
Clcn4-Related X-Linked Intellectual Disability Syndrome	Mental Retardation, X-Linked 15
X-Linked Mental Retardation 15	X-Linked Mental Retardation 49
Mental Retardation, X-Linked-49

Mitochondrial Dna Depletion Syndrome 4b

Mitochondrial Neurogastrointestinal Encephalopathy Syndrome	Mngie Syndrome
Thymidine Phosphorylase Deficiency	MTDPS4B
Mitochondrial Neurogastrointestinal Encephalopathy Disease	Mngie
Myoneurogastrointestinal Encephalopathy Syndrome	Ogimd
Oculogastrointestinal Muscular Dystrophy	Polip
Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudo-Obstruction	Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Polg-Related
Mngie, Polg-Related	Mepop
Mitochondrial Myopathy With Sensorimotor Polyneuropathy, Ophthalmoplegia, And Pseudo-Obstruction	Mngie Disease
Mitochondrial Dna Depletion Syndrome 4b Mngie Type	Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Polg-Related
Mngie Polg-Related	Mitochondrial Dna Depletion Syndrome, Type 4b
Visceral Myopathy Familial External Ophthalmoplegia

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08655	MRM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MRM1	VGNC	VGNC:31605
Felis catus	MRM1	VGNC	VGNC:63582
Rattus norvegicus	MRM1	RGD	RGD:1566232
Mus musculus	MRM1	MGD	MGI:2443470
Macaca mulatta	MRM1	VGNC	VGNC:74833
Canis familiaris	MRM1	VGNC	VGNC:43366