NXPE3 - neurexophilin and PC-esterase domain family member 3 Gene

Also Known as FAM55C; MST115; MSTP115

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91775

About NXPE3

This gene has 33 transcripts (splice variants), 504 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 6.4), lymph node (RPKM 5.0) and 24 other tissues.

Summary

This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

NXPE3 Products (11)

mRNA Protein Name
NM_001134456.2 NP_001127928.1 NXPE family member 3 isoform 1 precursor
NM_001348990.2 NP_001335919.1 NXPE family member 3 isoform 1 precursor
NM_001348991.2 NP_001335920.1 NXPE family member 3 isoform 1 precursor
NM_001348992.2 NP_001335921.1 NXPE family member 3 isoform 1 precursor
NM_001348993.2 NP_001335922.1 NXPE family member 3 isoform 1 precursor
NM_001348994.2 NP_001335923.1 NXPE family member 3 isoform 1 precursor
NM_001348995.2 NP_001335924.1 NXPE family member 3 isoform 1 precursor
NM_001348996.2 NP_001335925.1 NXPE family member 3 isoform 2
NM_001348997.2 NP_001335926.1 NXPE family member 3 isoform 2
NM_001348998.2 NP_001335927.1 NXPE family member 3 isoform 2
NM_145037.4 NP_659474.1 NXPE family member 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NXPE3 Protein Structure

Neurexophilin

Neurexophilin: Neurexophilin (74 - 284)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

NXPE family member 3

  • family with sequence similarity 55, member C

NXPE3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NXPE3 Q969Y0 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
NXPE3 Q969Y0 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
NXPE3 Q969Y0 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra
NXPE3 Q969Y0 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra
NXPE3 Q969Y0 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
NXPE3 Q969Y0 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
NXPE3 Q969Y0 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra
NXPE3 Q969Y0 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra
NXPE3 Q969Y0 OS9 Homo sapiens Q13438
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09716 NXPE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NXPE3 VGNC VGNC:32380
Mus musculus NXPE3 MGD MGI:2686598
Rattus norvegicus NXPE3 RGD RGD:1584648
Macaca mulatta NXPE3 VGNC VGNC:75476
Felis catus NXPE3 VGNC VGNC:63938
Canis familiaris NXPE3 VGNC VGNC:44075
Others NXPE3 NCBI