ERVFRD-1 - endogenous retrovirus group FRD member 1, envelope Gene
Also Known as envFRD; UNQ6191; ERVFRDE1; GLLL6191; HERV-FRD; HERV-W/FRD
Species: Homo sapiens
Summary
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]
Biased expression in placenta (RPKM 15.8) and lung (RPKM 0.4).
ERVFRD-1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_207582.3 | NP_997465.1 | syncytin-2 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within myoblast fusion |
IMP
IMP: Inferred from mutant phenotype
|
27589388 | GOA |
| involved in syncytium formation |
IDA
IDA: Inferred from direct assay
|
23492904 | GOA |
| involved in syncytium formation by plasma membrane fusion |
IDA
IDA: Inferred from direct assay
|
14557543 | GOA |
Compound Screening Libraries
Virtual Screening
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ERVFRD-1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ERVFRD-1 | P60508 | SLC30A8 | Homo sapiens | Q8IWU4 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | CCL4L1 | Homo sapiens | Q8NHW4 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | SLC41A2 | Homo sapiens | Q96JW4 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | TMPRSS4 | Homo sapiens | Q9NRS4 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | NINJ2 | Homo sapiens | Q9NZG7 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | ERMP1 | Homo sapiens | Q7Z2K6 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | GPHB5 | Homo sapiens | Q86YW7 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | GIMAP1 | Homo sapiens | Q8WWP7 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | NXPE3 | Homo sapiens | Q969Y0 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | EHHADH | Homo sapiens | Q08426 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | PMP22 | Homo sapiens | Q01453 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | TMEM60 | Homo sapiens | Q9H2L4 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | FAM3C | Homo sapiens | Q92520 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | BCL2L2 | Homo sapiens | Q92843 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | TAP1 | Homo sapiens | Q03518 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | SEC22A | Homo sapiens | Q96IW7 | 32296183 | |
|
Intra
|
ERVFRD-1 | P60508 | CACNG1 | Homo sapiens | Q06432 | 32296183 |