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CCL4L1 - C-C motif chemokine ligand 4 like 1 Gene

Also Known as LAG1; CCL4L; LAG-1; SCYA4L; AT744.2; SCYA4L1; SCYA4L2; MIP-1-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 388372

About CCL4L1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:33,500,001-39,800,000

Summary

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CCL4L1 Products (1)

mRNA	Protein	Name
NM_207007.3	NP_996890.1	C-C motif chemokine 4-like precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C-C motif chemokine 4-like	CC chemokine ligand 4L1

CCL4L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCL4L1	Q8NHW4	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	ITM2C	Homo sapiens	Q9NQX7-3	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	ITM2C	Homo sapiens	Q9NQX7-3	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	ITM2C	Homo sapiens	Q9NQX7-3	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	SLC10A2	Homo sapiens	Q12908	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	SLC10A2	Homo sapiens	Q12908	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	CATSPER4	Homo sapiens	Q7RTX7	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	CATSPER4	Homo sapiens	Q7RTX7	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	COMT	Homo sapiens	P21964	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	COMT	Homo sapiens	P21964	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	MFSD5	Homo sapiens	Q6N075	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	MFSD5	Homo sapiens	Q6N075	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	SLC7A14	Homo sapiens	Q8TBB6	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	CCL4L1	Q8NHW4	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	CCL4L1	Q8NHW4	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	CCL4L1	Q8NHW4	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL4L1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7257	CCL4 Protein, Human	P13236 (A24-N92)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74342	CCL4 Protein, Human (P.pastoris, His)	P13236 (A24-Q92)	≥ 90%, as determined by reducing SDS-PAGE.

CCL4L1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82814	CCL4 beta Antibody (YA2559)	WB, ICC/IF, IP	Human, Mouse

Related Diseases

Diseases	Alias
Marburg Hemorrhagic Fever	Marburg Virus Disease Marburg Disease Green Monkey Disease Mhf Vervet Monkey Disease Mard - [Marburg Disease] Mvd - [Marburg Virus Disease] Marburg Haemorrhagic Fever Mhf - [Marburg Haemorrhagic Fever]
Vaginitis	Infective Vaginitis Inflammation Of Vagina Colpitis Vaginal Inflammation Vaginitis Nos
Bacterial Vaginosis	Vaginosis, Bacterial
Trichomoniasis	Trichomonas Infection Trichomonas Infections Disease Due To Trichomonadidae Infection By Trichomonas Trichomonadosis Trichomonas Pruritus Trichomonosis Tricomoniasis
Japanese Spotted Fever	Oriental Spotted Fever Rickettsia Japonica Spotted Fever
Vaginal Disease	Vaginal Diseases
Funisitis
Duodenum Adenoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02103	CCL4L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174752	Human CCL4L1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCL4L1	MGD	MGI:98261