CERS4 - ceramide synthase 4 Gene

Also Known as Trh1; LASS4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79603

About CERS4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,209,370-8,262,421 (from NCBI)

This gene has 16 transcripts (splice variants), 301 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 13.9), prostate (RPKM 10.3) and 24 other tissues.

Summary

Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

CERS4 Products (1)

mRNA Protein Name
NM_024552.3 NP_078828.2 ceramide synthase 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sphingosine N-acyltransferase activity IDA
IDA: Inferred from direct assay
17977534 GOA
Biological Process GO Annotation Evidence References Source
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
17977534 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CERS4 Protein Structure

Homeobox

Homeobox: Homeobox domain (82 - 126)

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (132 - 325)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

ceramide synthase 4

  • LAG1 homolog, ceramide synthase 4

CERS4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CERS4 Q9HA82 TEX264 Homo sapiens Q9Y6I9
Validated Y2H
32296183
Intra
CERS4 Q9HA82 SLC13A4 Homo sapiens Q9UKG4
Validated Y2H
32296183
Intra
CERS4 Q9HA82 SLC35A1 Homo sapiens P78382
Y2H Array
32296183
Intra
CERS4 Q9HA82 SCD Homo sapiens O00767
Y2H Array
32296183
Intra
CERS4 Q9HA82 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra
CERS4 Q9HA82 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
Intra
CERS4 Q9HA82 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Her2-Receptor Negative Breast Cancer
Dermatitis, Atopic, 2

  • Atopic Dermatitis 2

  • ATOD2

  • Dermatitis, Atopic, Susceptibility To, 2

  • Dermatitis, Atopic, 2, Susceptibility To

  • Dermatitis, Atopic 2

  • Dermatitis Atopic 2

  • Atopic Eczema

  • Dermatitis, Atopic, Type 2

  • Dermatitis, Atopic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133490A ST1074 Inducer 99.41% Unkown
HY-RS02539 CERS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-133488 ST1072 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CERS4 VGNC VGNC:60794
Canis familiaris CERS4 VGNC VGNC:39150
Rattus norvegicus CERS4 RGD RGD:1309303
Bos taurus CERS4 VGNC VGNC:27226
Mus musculus CERS4 MGD MGI:1914510
Macaca mulatta CERS4 VGNC VGNC:71077
Others CERS4 NCBI