SCD - stearoyl-CoA desaturase Gene

Also Known as SCD1; FADS5; SCDOS; hSCD1; MSTP008

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6319

About SCD

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,347,233-100,364,826 (from NCBI)

This gene has 1 transcript (splice variant), 312 orthologues and 1 paralogue. Biased expression in fat (RPKM 972.1), brain (RPKM 238.0) and 4 other tissues.

Summary

This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]

SCD Products (1)

mRNA Protein Name
NM_005063.5 NP_005054.3 stearoyl-CoA desaturase

SCD Protein Structure

FA_desaturase

FA_desaturase: Fatty acid desaturase (100 - 308)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

stearoyl-CoA desaturase

  • acyl-CoA desaturase

  • delta(9)-desaturase

  • fatty acid desaturase

  • predicted protein of HQ0998

  • stearoyl-CoA desaturase (delta-9-desaturase)

  • stearoyl-CoA desaturase opposite strand

SCD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCD O00767 RETREG3 Homo sapiens Q86VR2 32296183
Intra
SCD O00767 RETREG3 Homo sapiens Q86VR2 32296183
Intra
SCD O00767 RETREG3 Homo sapiens Q86VR2 32296183
Intra
SCD O00767 JAGN1 Homo sapiens Q8N5M9 32296183
Intra
SCD O00767 JAGN1 Homo sapiens Q8N5M9 32296183
Intra
SCD O00767 JAGN1 Homo sapiens Q8N5M9 32296183
Intra
SCD O00767 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
SCD O00767 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
SCD O00767 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
SCD O00767 SPAG4 Homo sapiens Q9NPE6 32296183
Intra
SCD O00767 SPAG4 Homo sapiens Q9NPE6 32296183
Intra
SCD O00767 SPAG4 Homo sapiens Q9NPE6 32296183
Intra
SCD O00767 REEP2 Homo sapiens Q9BRK0 32296183
Intra
SCD O00767 REEP2 Homo sapiens Q9BRK0 32296183
Intra
SCD O00767 REEP2 Homo sapiens Q9BRK0 32296183
Intra
SCD O00767 GPX8 Homo sapiens Q8TED1 32296183
Intra
SCD O00767 GPX8 Homo sapiens Q8TED1 32296183
Intra
SCD O00767 GPX8 Homo sapiens Q8TED1 32296183
Intra
SCD O00767 KCNJ6 Homo sapiens P48051 32296183
Intra
SCD O00767 KCNJ6 Homo sapiens P48051 32296183
Intra
SCD O00767 KCNJ6 Homo sapiens P48051 32296183
Intra
SCD O00767 STOM Homo sapiens P27105 32296183
Intra
SCD O00767 STOM Homo sapiens P27105 32296183
Intra
SCD O00767 STOM Homo sapiens P27105 32296183
Intra
SCD O00767 TMPRSS2 Homo sapiens O15393-2 32296183
Intra
SCD O00767 TMPRSS2 Homo sapiens O15393-2 32296183
Intra
SCD O00767 TMPRSS2 Homo sapiens O15393-2 32296183
Intra
SCD O00767 TMPRSS2 Homo sapiens O15393-2 32296183
Intra
SCD O00767 CLEC12B Homo sapiens Q2HXU8-2 32296183
Intra
SCD O00767 CLEC12B Homo sapiens Q2HXU8-2 32296183
Intra
SCD O00767 CLEC12B Homo sapiens Q2HXU8-2 32296183
Intra
SCD O00767 TLCD4 Homo sapiens Q96MV1 32296183
Intra
SCD O00767 TLCD4 Homo sapiens Q96MV1 32296183
Intra
SCD O00767 TLCD4 Homo sapiens Q96MV1 32296183
Intra
SCD O00767 AQP6 Homo sapiens Q13520 32296183
Intra
SCD O00767 AQP6 Homo sapiens Q13520 32296183
Intra
SCD O00767 AQP6 Homo sapiens Q13520 32296183
Intra
SCD O00767 GPR152 Homo sapiens Q8TDT2 32296183
Intra
SCD O00767 GPR152 Homo sapiens Q8TDT2 32296183
Intra
SCD O00767 GPR152 Homo sapiens Q8TDT2 32296183
Intra
SCD O00767 SCN3B Homo sapiens Q9NY72 32296183
Intra
SCD O00767 SCN3B Homo sapiens Q9NY72 32296183
Intra
SCD O00767 SCN3B Homo sapiens Q9NY72 32296183
Intra
SCD O00767 GJB1 Homo sapiens P08034 32296183
Intra
SCD O00767 GJB1 Homo sapiens P08034 32296183
Intra
SCD O00767 GJB1 Homo sapiens P08034 32296183
Intra
SCD O00767 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
SCD O00767 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
SCD O00767 HSD17B13 Homo sapiens Q7Z5P4 32296183
Intra
SCD O00767 GPR42 Homo sapiens O15529 32296183
Intra
SCD O00767 GPR42 Homo sapiens O15529 32296183
Intra
SCD O00767 GPR42 Homo sapiens O15529 32296183
Intra
SCD O00767 SLC10A6 Homo sapiens Q3KNW5 32296183
Intra
SCD O00767 SLC10A6 Homo sapiens Q3KNW5 32296183
Intra
SCD O00767 SLC10A6 Homo sapiens Q3KNW5 32296183
Intra
SCD O00767 MARCHF5 Homo sapiens Q9NX47 32296183
Intra
SCD O00767 MARCHF5 Homo sapiens Q9NX47 32296183
Intra
SCD O00767 MARCHF5 Homo sapiens Q9NX47 32296183
Intra
SCD O00767 CERS4 Homo sapiens Q9HA82 32296183
Intra
SCD O00767 CERS4 Homo sapiens Q9HA82 32296183
Intra
SCD O00767 CYBC1 Homo sapiens Q9BQA9 32296183
Intra
SCD O00767 CYBC1 Homo sapiens Q9BQA9 32296183
Intra
SCD O00767 CYBC1 Homo sapiens Q9BQA9 32296183
Intra
SCD O00767 MCFD2 Homo sapiens Q8NI22 32296183
Intra
SCD O00767 MCFD2 Homo sapiens Q8NI22 32296183
Intra
SCD O00767 MCFD2 Homo sapiens Q8NI22 32296183
Intra
SCD O00767 SEC11C Homo sapiens Q9BY50 32296183
Intra
SCD O00767 SEC11C Homo sapiens Q9BY50 32296183
Intra
SCD O00767 SEC11C Homo sapiens Q9BY50 32296183
Intra
SCD O00767 CD207 Homo sapiens Q9UJ71 32296183
Intra
SCD O00767 CD207 Homo sapiens Q9UJ71 32296183
Intra
SCD O00767 CD207 Homo sapiens Q9UJ71 32296183
Intra
SCD O00767 RNF5 Homo sapiens Q99942 32296183
Intra
SCD O00767 RNF5 Homo sapiens Q99942 32296183
Intra
SCD O00767 RNF5 Homo sapiens Q99942 32296183
Intra
SCD O00767 MFSD14B Homo sapiens Q5SR56 32296183
Intra
SCD O00767 MFSD14B Homo sapiens Q5SR56 32296183
Intra
SCD O00767 MFSD14B Homo sapiens Q5SR56 32296183
Intra
SCD O00767 CD33 Homo sapiens P20138 32296183
Intra
SCD O00767 CD33 Homo sapiens P20138 32296183
Intra
SCD O00767 CD33 Homo sapiens P20138 32296183
Intra
SCD O00767 PVR Homo sapiens P15151 32296183
Intra
SCD O00767 PVR Homo sapiens P15151 32296183
Intra
SCD O00767 PVR Homo sapiens P15151 32296183
Intra
SCD O00767 MTIF3 Homo sapiens Q9H2K0 32296183
Intra
SCD O00767 MTIF3 Homo sapiens Q9H2K0 32296183
Intra
SCD O00767 MTIF3 Homo sapiens Q9H2K0 32296183
Intra
SCD O00767 SLC7A14 Homo sapiens Q8TBB6 32296183
Intra
SCD O00767 SLC7A14 Homo sapiens Q8TBB6 32296183
Intra
SCD O00767 SLC7A14 Homo sapiens Q8TBB6 32296183
Intra
SCD O00767 TIMMDC1 Homo sapiens Q9NPL8 32296183
Intra
SCD O00767 TIMMDC1 Homo sapiens Q9NPL8 32296183
Intra
SCD O00767 TIMMDC1 Homo sapiens Q9NPL8 32296183
Intra
SCD O00767 TMX2 Homo sapiens Q9Y320 32296183
Intra
SCD O00767 TMX2 Homo sapiens Q9Y320 32296183
Intra
SCD O00767 TMX2 Homo sapiens Q9Y320 32296183
Intra
SCD O00767 CREB3L1 Homo sapiens Q96BA8 32296183
Intra
SCD O00767 CREB3L1 Homo sapiens Q96BA8 32296183
Intra
SCD O00767 CREB3L1 Homo sapiens Q96BA8 32296183
Intra
SCD O00767 MGST3 Homo sapiens O14880 32296183
Intra
SCD O00767 MGST3 Homo sapiens O14880 32296183
Intra
SCD O00767 MGST3 Homo sapiens O14880 32296183
Intra
SCD O00767 ERGIC3 Homo sapiens Q9Y282 32296183
Intra
SCD O00767 ERGIC3 Homo sapiens Q9Y282 32296183
Intra
SCD O00767 ERGIC3 Homo sapiens Q9Y282 32296183
Intra
SCD O00767 CYB561 Homo sapiens P49447 32296183
Intra
SCD O00767 CYB561 Homo sapiens P49447 32296183
Intra
SCD O00767 CYB561 Homo sapiens P49447 32296183
Intra
SCD O00767 TMEM30B Homo sapiens Q3MIR4 32296183
Intra
SCD O00767 TMEM30B Homo sapiens Q3MIR4 32296183
Intra
SCD O00767 TMEM30B Homo sapiens Q3MIR4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SCD Antibodies

Cat. No. Product Name Application Reactivity
HY-P81418 SCD1 Antibody (YA1163) IHC-P Human
HY-P81418A SCD1 Antibody (YA1163)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Abdominal Obesity-Metabolic Syndrome 1
  • Metabolic Syndrome X

  • Metabolic Syndrome

  • AOMS1

  • Dysmetabolic Syndrome X

  • Metabolic Disease

  • Abdominal Obesity Metabolic Syndrome

Non-Alcoholic Fatty Liver Disease
  • Fatty Liver

  • Non-Alcoholic Fatty Liver

  • Nafld

  • Nonalcoholic Fatty Liver Disease

  • Nonalcoholic Steatohepatitis

  • Steatosis

  • Nafl

  • Nash

  • Non-Alcoholic Steatohepatitis

  • Susceptibility To Nonalcoholic Fatty Liver Disease

  • Steatohepatitis

  • Fatty Degeneration

  • Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

  • Nafld Without Nash

  • Nafld Without Mention Of Nash

Non-Alcoholic Steatohepatitis
  • Nonalcoholic Steatohepatitis

  • Nash

  • Nash - [Non-Alcoholic Steatohepatitis]

  • Non-Alcoholic Steatohepatosis

Skin Disease
  • Skin Diseases

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Genodermatosis

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders

Fatty Liver Disease
  • Alcoholic Fatty Liver

  • Fatty Liver

  • Fatty Liver, Alcoholic

  • Fatty Change Of Liver

  • Hepatic Lipidosis

  • Steatosis Of Liver

  • Fatty Liver Alcoholic

  • Steatohepatitis

  • Etoh Fatty Liver

  • Etoh Fatty Liver Metamorphosis

  • Fatty Etoh Liver Necrosis

Lipid Storage Disease
  • Lipoidosis

  • Inborn Lipid Storage Disorder

  • Lipoid Storage Diseas

  • Lipid Storage Diseases

  • Lipidoses

Fetal Akinesia Deformation Sequence 1
  • Fetal Akinesia Deformation Sequence

  • Fads

  • Fetal Akinesia Sequence

  • FADS1

  • Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome Type 1

  • Fetal Akinesia Deformation Sequence Syndrome

  • Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

  • Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome, Type I

  • Foetal Akinesia Deformation Sequence Syndrome

  • Foetal Akinesia Sequence

  • Fetal Akinesia Deformation Sequence Syndrome 1

  • Pena-Shokeir Syndrome, Type 1

  • Pena Shokeir Syndrome, Type 1

  • Akinesia, Fetal, Deformation Sequence

  • Akinesia, Fetal, Deformation Sequence, Type 1

  • Pena-Shokeir Syndrome Type I

Body Mass Index Quantitative Trait Locus 11
  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis

Diabetes Mellitus
  • Diabetes

Homocystinuria
  • Cystathionine Beta Synthase Deficiency

  • Homocysteinemia

  • Cbs Deficiency

  • Cystathionine Synthase Deficiency

  • Cystathionine Beta-Synthase Deficiency Disease

Type 2 Diabetes Mellitus
  • Insulin Resistance

  • NIDDM

  • Diabetes Mellitus, Non-Insulin-Dependent

  • Type 2 Diabetes

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta SCD VGNC VGNC:106098
Bos taurus SCD VGNC VGNC:106916
Felis catus SCD VGNC VGNC:64904
Rattus norvegicus SCD RGD RGD:621176
Canis familiaris SCD VGNC VGNC:45900
Others SCD NCBI