1. Metabolic Enzyme/Protease
  2. Stearoyl-CoA Desaturase (SCD)
  3. XEN723

XEN723 

Cat. No.: HY-100249
Handling Instructions

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.

For research use only. We do not sell to patients.

XEN723 Chemical Structure

XEN723 Chemical Structure

CAS No. : 1072803-08-7

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Description

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.

IC50 & Target

IC50: 45 nM (SCD1 in Mouse), 524 nM (SCD1 in HepG2 cell)[1]

In Vitro

XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit[1].

Molecular Weight

425.48

Formula

C₂₁H₂₀FN₅O₂S

CAS No.

1072803-08-7

SMILES

O=C(C1=C(C)N=C(N2CCN(CC3=CC=C(F)C=C3)C2=O)S1)NCC4=CC=CN=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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XEN723
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