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A939572

HY-50709

(stearoyl-CoA desaturase (SCD) inhibitor; SCD-inhibitor; 1-Piperidinecarboxamide, 4-(2-chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-)

A939572

A939572 Chemical Structure

A939572 (SCD1 inhibitor) is a potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1 respectively.

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Free sample   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
2 mg $60 In-stock
5 mg $90 In-stock
10 mg $120 In-stock
50 mg $480 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €75 In-stock
2 mg €59 In-stock
5 mg €88 In-stock
10 mg €118 In-stock
50 mg €470 In-stock
100 mg Get quote
200 mg Get quote

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Product name: A939572
Cat. No.: HY-50709

A939572 Data Sheet

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    Purity: 99.79%

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Biological Activity of A939572

A939572 (SCD1 inhibitor) is a potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitor with IC50 values of  <4 nM and 37 nM for mSCD1 and hSCD1 respectively.
IC50 value: <4 nM (mSCD1); 37 nM (hSCD1) [1]
Target: SCD1
in vitro: A939572 is a small molecule that specifically inhibits SCD1 enzymatic activity. A939572 showed a significant dose-dependent decrease in proliferation in Caki1, A498, Caki2, and ACHN at day 5 (IC50s of 65, 50, 65, and 6 nmol/L, respectively). In congruity with previous experimentation examining SCD1 lentiviral knockdown models, A939572 induced apoptosis confirmed by PARP cleavage via Western blot analysis in all 4 cell lines. InA939572 (SCDi) treated Caki1 and A498 cells, all 5 endoplasmic reticulum stress related genes were expressed at significantly increased levels compared to DMSO t BSA control, and this elevated expression could be blocked with the addition of OA-BSA [2].
in vivo: Athymic nude (nu/nu) mice bearing A498 ccRCC xenografts were treated with A939572 and Tem individually or in
combination over the course of 4 weeks, and tumor volume (mm3) was recorded [2].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 387.86 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C20H22ClN3O3
CAS No 1032229-33-6
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.5782 mL 12.8912 mL 25.7825 mL
5 mM 0.5156 mL 2.5782 mL 5.1565 mL
10 mM 0.2578 mL 1.2891 mL 2.5782 mL

References on A939572

Inhibitor Kit
  • PluriSln 1

    PluriSln 1(NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs.

  • SCD inhibitor 1

    SCD inhibitor 1 is a stearoyl-coa desaturase (SCD) extracted from patent WO/2009060053 A1, compound example 16.