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Products are for research use only. Not for human use. We do not sell to patients.
(stearoyl-CoA desaturase (SCD) inhibitor; SCD-inhibitor; 1-Piperidinecarboxamide, 4-(2-chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-)
A939572 Chemical Structure
|Product name: A939572|
|Cat. No.: HY-50709|
A939572 (SCD1 inhibitor) is a potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1 respectively.
IC50 value: <4 nM (mSCD1); 37 nM (hSCD1) 
in vitro: A939572 is a small molecule that specifically inhibits SCD1 enzymatic activity. A939572 showed a significant dose-dependent decrease in proliferation in Caki1, A498, Caki2, and ACHN at day 5 (IC50s of 65, 50, 65, and 6 nmol/L, respectively). In congruity with previous experimentation examining SCD1 lentiviral knockdown models, A939572 induced apoptosis confirmed by PARP cleavage via Western blot analysis in all 4 cell lines. InA939572 (SCDi) treated Caki1 and A498 cells, all 5 endoplasmic reticulum stress related genes were expressed at significantly increased levels compared to DMSO t BSA control, and this elevated expression could be blocked with the addition of OA-BSA .
in vivo: Athymic nude (nu/nu) mice bearing A498 ccRCC xenografts were treated with A939572 and Tem individually or in
combination over the course of 4 weeks, and tumor volume (mm3) was recorded .
|M.Wt||387.86||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 56 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.5782 mL||12.8912 mL||25.7825 mL|
|5 mM||0.5156 mL||2.5782 mL||5.1565 mL|
|10 mM||0.2578 mL||1.2891 mL||2.5782 mL|
PluriSln 1(NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs.
SCD inhibitor 1 is a stearoyl-coa desaturase (SCD) extracted from patent WO/2009060053 A1, compound example 16.