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Avasimibe (Synonyms: CI-1011; PD-148515)

Cat. No.: HY-13215 Purity: 99.25%
Data Sheet SDS Handling Instructions

Avasimibe is a ACAT inhibitor incluing ACAT-1 and ACAT-2 In vitro: 1) Avasimibe has beneficial on plasma lipids and direct antiatherosclerotic activity, independent of lipid effects, in various animal models of hypercholesterolemia 2) Avasimibe enhances the lipid lowering effect of atorvastatin in subjects with homozygousfamilial hypercholesterolemia.

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Avasimibe Chemical Structure

Avasimibe Chemical Structure

CAS No. : 166518-60-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $60 In-stock
50 mg $180 In-stock
100 mg $330 In-stock
200 mg $530 In-stock
500 mg   Get quote  
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Description

Avasimibe is a ACAT inhibitor incluing ACAT-1 and ACAT-2 In vitro: 1) Avasimibe has beneficial on plasma lipids and direct antiatherosclerotic activity, independent of lipid effects, in various animal models of hypercholesterolemia 2) Avasimibe enhances the lipid lowering effect of atorvastatin in subjects with homozygousfamilial hypercholesterolemia. In vivo: 1) The reference for administration is daily dosages up to 1000 mg/d for up to 2 weeks and 750 mg/d for up to 8 weeks. 2) Avasimibe reduced plasma apoB levels by 20% in A-PLUS when given at a dose of 750 mg. 3) Avasimibe can potently lowered plasma cholesterol levels in ApoE*3-Leiden mice and considerably reduced atherosclerotic lesion area in addition to its cholesterol-lowering effect.

References
Molecular Weight

501.72

Formula

C₂₉H₄₃NO₄S

CAS No.

166518-60-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 28 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Avasimibe
Cat. No.:
HY-13215
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