1. Metabolic Enzyme/Protease
  2. Acyltransferase

Avasimibe (Synonyms: CI-1011; PD-148515)

Cat. No.: HY-13215 Purity: 99.25%
Handling Instructions

Avasimibe is a ACAT inhibitor incluing ACAT-1 and ACAT-2 In vitro: 1) Avasimibe has beneficial on plasma lipids and direct antiatherosclerotic activity, independent of lipid effects, in various animal models of hypercholesterolemia 2) Avasimibe enhances the lipid lowering effect of atorvastatin in subjects with homozygousfamilial hypercholesterolemia.

For research use only. We do not sell to patients.

Avasimibe Chemical Structure

Avasimibe Chemical Structure

CAS No. : 166518-60-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg USD 396 In-stock
Estimated Time of Arrival: December 31
200 mg USD 636 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Avasimibe is a ACAT inhibitor incluing ACAT-1 and ACAT-2 In vitro: 1) Avasimibe has beneficial on plasma lipids and direct antiatherosclerotic activity, independent of lipid effects, in various animal models of hypercholesterolemia 2) Avasimibe enhances the lipid lowering effect of atorvastatin in subjects with homozygousfamilial hypercholesterolemia. In vivo: 1) The reference for administration is daily dosages up to 1000 mg/d for up to 2 weeks and 750 mg/d for up to 8 weeks. 2) Avasimibe reduced plasma apoB levels by 20% in A-PLUS when given at a dose of 750 mg. 3) Avasimibe can potently lowered plasma cholesterol levels in ApoE*3-Leiden mice and considerably reduced atherosclerotic lesion area in addition to its cholesterol-lowering effect.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 28 mg/mL (55.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9931 mL 9.9657 mL 19.9314 mL
5 mM 0.3986 mL 1.9931 mL 3.9863 mL
10 mM 0.1993 mL 0.9966 mL 1.9931 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

501.72

Formula

C₂₉H₄₃NO₄S

CAS No.

166518-60-1

SMILES

O=C(NS(=O)(OC1=C(C(C)C)C=CC=C1C(C)C)=O)CC2=C(C(C)C)C=C(C(C)C)C=C2C(C)C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Avasimibe
Cat. No.:
HY-13215
Quantity:

Avasimibe

Cat. No.: HY-13215