1. Metabolic Enzyme/Protease
  2. ATP Citrate Lyase
  3. SB 204990

SB 204990 

Cat. No.: HY-16450 Purity: >98.0%
Handling Instructions

SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

For research use only. We do not sell to patients.

SB 204990 Chemical Structure

SB 204990 Chemical Structure

CAS No. : 154566-12-8

Size Price Stock
5 mg USD 180 Ask For Quote & Lead Time
10 mg USD 330 Ask For Quote & Lead Time

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SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

IC50 & Target


In Vitro

SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels[1].

In Vivo

SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels[2].

Molecular Weight







O=C(O)C[[email protected]]1(O)C(O[[email protected]](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O


Room temperature in continental US; may vary elsewhere

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (25.69 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5689 mL 12.8446 mL 25.6891 mL
5 mM 0.5138 mL 2.5689 mL 5.1378 mL
10 mM 0.2569 mL 1.2845 mL 2.5689 mL
*Please refer to the solubility information to select the appropriate solvent.

Purity: >98.0%

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