1. Metabolic Enzyme/Protease
  2. ATP Citrate Lyase
  3. SB 204990

SB 204990 

Cat. No.: HY-16450 Purity: 99.50%
Handling Instructions

SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

For research use only. We do not sell to patients.

SB 204990 Chemical Structure

SB 204990 Chemical Structure

CAS No. : 154566-12-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 127 In-stock
Estimated Time of Arrival: December 31
5 mg USD 115 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 715 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1240 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

IC50 & Target

ACLY[1].

In Vitro

SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

389.27

Formula

C₁₈H₂₂Cl₂O₅

CAS No.
SMILES

O=C(O)C[[email protected]]1(O)C(O[[email protected]](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (256.89 mM)

H2O : 10 mg/mL (25.69 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5689 mL 12.8446 mL 25.6891 mL
5 mM 0.5138 mL 2.5689 mL 5.1378 mL
10 mM 0.2569 mL 1.2845 mL 2.5689 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 2.56 mg/mL (6.58 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.50%

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Keywords:

SB 204990SB204990SB-204990ATP Citrate LyaseACLYInhibitorinhibitorinhibit

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Product Name:
SB 204990
Cat. No.:
HY-16450
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