1. Metabolic Enzyme/Protease
  2. ATP Citrate Lyase

SB 204990 

Cat. No.: HY-16450 Purity: >98.0%
Handling Instructions

SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

For research use only. We do not sell to patients.

SB 204990 Chemical Structure

SB 204990 Chemical Structure

CAS No. : 154566-12-8

Size Price Stock
5 mg USD 180 Get quote
10 mg USD 330 Get quote

* Please select Quantity before adding items.

Customer Review

Featured Recommendations

Related Small Molecules:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

IC50 & Target


In Vitro

SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels[1].

In Vivo

SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5689 mL 12.8446 mL 25.6891 mL
5 mM 0.5138 mL 2.5689 mL 5.1378 mL
10 mM 0.2569 mL 1.2845 mL 2.5689 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







O=C(O)C[[email protected]]1(O)C(O[[email protected]](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name



Applicant name *


Email address *

Phone number *


Organization name *

Country or Region *


Requested quantity *


Bulk Inquiry

Inquiry Information

Product Name:
SB 204990
Cat. No.:

SB 204990

Cat. No.: HY-16450