1. Metabolic Enzyme/Protease
    Autophagy
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
  3. Atorvastatin

Atorvastatin 

Cat. No.: HY-B0589
COA Handling Instructions

Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.

For research use only. We do not sell to patients.

Atorvastatin Chemical Structure

Atorvastatin Chemical Structure

CAS No. : 134523-00-5

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Solution
10 mM * 1 mL in DMSO USD 55 Ask For Quote & Lead Time
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50 mg USD 120 Ask For Quote & Lead Time
100 mg USD 150 Ask For Quote & Lead Time

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Top Publications Citing Use of Products

    Atorvastatin purchased from MCE. Usage Cited in: Oncogene. 2022 Oct 31.  [Abstract]

    ATP assay. The combination of Atorvastatin (2.5, 5, 10, 20 μM; 48 h) and SR1078 synergistically inhibits CRC cell viability.

    Atorvastatin purchased from MCE. Usage Cited in: Endocrinology. 2018 May 1;159(5):2008-2021.  [Abstract]

    Male C57BL/6 mice are intragastrically treated with Atorvastatin (0.1 mg/kg/day) and placebo for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection. H&E and oil red O staining of frozen liver sections.
    • Biological Activity

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    Description

    Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

    In Vitro

    Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE−/− mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Forty 8-week-old ApoE−/− mice induced with angiotensin II (Ang II)[5]
    Dosage: 20 mg/kg, 30 mg/kg
    Administration: Oral gavage; once a day; for 28 days
    Result: Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE−/− mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited.
    Clinical Trial
    Molecular Weight

    558.64

    Formula

    C33H35FN2O5

    CAS No.
    SMILES

    O=C(C(C(C1=CC=CC=C1)=C(C2=CC=C(F)C=C2)N3CC[[email protected]@H](O)C[[email protected]@H](O)CC(O)=O)=C3C(C)C)NC4=CC=CC=C4

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (89.50 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7901 mL 8.9503 mL 17.9006 mL
    5 mM 0.3580 mL 1.7901 mL 3.5801 mL
    10 mM 0.1790 mL 0.8950 mL 1.7901 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.48 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.48 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.51%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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