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Atorvastatin calcium hydrate

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Based on 69 publication(s) in Google Scholar

Atorvastatin calcium salt trihydrate is a drug belonging to the statin class of drugs used to lower blood cholesterol levels. Atorvastatin calcium salt trihydrate has unique chemical properties that make it an effective tool in controlling high levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the body, reducing the risk of heart attack and stroke. Atorvastatin calcium salt trihydrate works by inhibiting HMG-CoA reductase, the enzyme responsible for producing cholesterol in the liver.

For research use only. We do not sell to patients.

  • Purity: 99.83%
  • CAS No.: 344423-98-9
  • Formula: C33H35FN2O5.1/2Ca.3/2H2O
  • Molecular Weight:605.71
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Atorvastatin calcium hydrate Chemical Structure
    Atorvastatin calcium hydrate Chemical Structure
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
  • Experimental Validation Results for Atorvastatin calcium hydrate
CAS No.: 344423-98-9
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  • Atorvastatin calcium hydrate Chemical Structure
    Atorvastatin calcium hydrate Chemical Structure
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    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Oct;7(10):2142-2164. [Abstract]

    Customer Validation
     Representative histogram and quantification of normalized MHC I membrane levels determined by flow cytometry (stained for anti-HLA-A, anti-HLA-B and anti-HLA-C) in response to indicated treatment conditions in iAstrocytes (N = 4–6; three (control and cholesterol) or two (Atorvastatin hemicalcium salt) independent experiments from two isogenic sets. Data are shown as the mean. *P < 0.05 (two-sided one-sample t-test for cholesterol and atorvastatin versus 1).

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Oct;7(10):2142-2164. [Abstract]

    Customer Validation
     Secreted Il-6 levels in medium of ApoE3 iAstrocytes that were pretreated with or without exogenous Cholesterol (10 μM) or Atorvastatin hemicalcium salt (0.5 μM) for 1 h before 24-h cotreatment with increasing doses of TNF, IL-1α and C1q.

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Oct:146:157128. [Abstract]

    Customer Validation
     ApoE-/- mice were administrated with high-fat-diet accompanied by MFEVLPs (5 or 50 μg/d, i.p) or Atorvastatin (10 mg/kg/day, i.g) for 12 weeks.

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Environ Sci Technol Lett. 2025 Apr 8.

    Customer Validation
     The hCMEC-D3 cells were exposed to 0.01 μM 77PD-Q for 24 h in the presence or absence of 0.3 μM Atorvastatin (0.3 μM, 24 h).

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]

    Customer Validation
     Representative images of p-AKT1 staining of liver sections of the DMSO, Simvastatin and Atorvastatin hemicalcium salt (20 mg/kg, 3 days, atorvastatin with HFD)‐treated mice.

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]

    Customer Validation
     Western blotting of PAQR9 in mouse primary hepatocytes under the treatment of DMSO, Simvastatin (Sim), Atorvastatin hemicalcium salt (Ator, 10 mmol/L, 24-48 h) and Rosuvastatin (Rosu).

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]

    Customer Validation
     The top 20 predicted transcription factors of differentially expressed genes under Atorvastatin hemicalcium salt treatment. The gene expression data were from GEO datasets GSE24188 and the TF prediction was by ChEA3. The bar showed rank score and the line showed the number of overlapped genes.

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Dec 25;8(1):457. [Abstract]

    Customer Validation
     EGFRvIII-high U87 cells were cocultured with EGFRvIII-CAR-T cells and treated with Atorvastatin (5 μM, 3 days) or Cytochalasin D (10 μg/mL, 1 day). Immunoblotting of magnetically separated cells showed that both drugs alleviated CAR molecule transfer (representative of three independent experiments).

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2023 Jan 1:552:215976. [Abstract]

    Customer Validation
     Panc-1 and MIA PaCa-2 cells were treated with Atorvastatin (20 μM or 50 μM) for 24 h. FOXM1 and mutant p53 protein levels were measured in different treatment groups.

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2022 Dec;41(49):5266-5278. [Abstract]

    Customer Validation
     ATP assay. The combination of Atorvastatin (2.5, 5, 10, 20 μM; 48 h) and SR1078 synergistically inhibits CRC cell viability.

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. [Abstract]

    Customer Validation
     Tumor volumes of indicated patient-derived xenografts (PDXs) treated with Atorvastatin (40 mg/kg, i.p., every two days for 30 days).

  • 1/16

    Atorvastatin calcium hydrate purchased from MedChemExpress. Usage Cited in: Endocrinology. 2018 May 1;159(5):2008-2021. [Abstract]

    Customer Validation
     Male C57BL/6 mice are intragastrically treated with Atorvastatin (0.1 mg/kg/day) and placebo for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection. H&E and oil red O staining of frozen liver sections.

  • Atorvastatin calcium hydrate