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Atorvastatin hemicalcium salt

(Synonyms: CI-981; Atorvastatin hemicalcium)
69 Cited Publications
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Based on 69 publication(s) in Google Scholar

Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, with blood-brain barrier permeability. Atorvastatin hemicalcium salt has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.94%
  • CAS No.: 134523-03-8
  • Formula: C33H34Ca0.5FN2O5
  • Molecular Weight:577.67
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Atorvastatin hemicalcium salt Chemical Structure
    Atorvastatin hemicalcium salt Chemical Structure
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
  • Experimental Validation Results for Atorvastatin hemicalcium salt
CAS No.: 134523-03-8
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  • Atorvastatin hemicalcium salt Chemical Structure
    Atorvastatin hemicalcium salt Chemical Structure
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    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Oct;7(10):2142-2164. [Abstract]

    Customer Validation
     Representative histogram and quantification of normalized MHC I membrane levels determined by flow cytometry (stained for anti-HLA-A, anti-HLA-B and anti-HLA-C) in response to indicated treatment conditions in iAstrocytes (N = 4–6; three (control and cholesterol) or two (Atorvastatin hemicalcium salt) independent experiments from two isogenic sets. Data are shown as the mean. *P < 0.05 (two-sided one-sample t-test for cholesterol and atorvastatin versus 1).

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    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Oct;7(10):2142-2164. [Abstract]

    Customer Validation
     Secreted Il-6 levels in medium of ApoE3 iAstrocytes that were pretreated with or without exogenous Cholesterol (10 μM) or Atorvastatin hemicalcium salt (0.5 μM) for 1 h before 24-h cotreatment with increasing doses of TNF, IL-1α and C1q.

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    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Oct:146:157128. [Abstract]

    Customer Validation
     ApoE-/- mice were administrated with high-fat-diet accompanied by MFEVLPs (5 or 50 μg/d, i.p) or Atorvastatin (10 mg/kg/day, i.g) for 12 weeks.

  • 1/16

    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Environ Sci Technol Lett. 2025 Apr 8.

    Customer Validation
     The hCMEC-D3 cells were exposed to 0.01 μM 77PD-Q for 24 h in the presence or absence of 0.3 μM Atorvastatin (0.3 μM, 24 h).

  • 1/16

    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]

    Customer Validation
     Representative images of p-AKT1 staining of liver sections of the DMSO, Simvastatin and Atorvastatin hemicalcium salt (20 mg/kg, 3 days, atorvastatin with HFD)‐treated mice.

  • 1/16

    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]

    Customer Validation
     Western blotting of PAQR9 in mouse primary hepatocytes under the treatment of DMSO, Simvastatin (Sim), Atorvastatin hemicalcium salt (Ator, 10 mmol/L, 24-48 h) and Rosuvastatin (Rosu).

  • 1/16

    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep;11(34):e2403451. [Abstract]

    Customer Validation
     The top 20 predicted transcription factors of differentially expressed genes under Atorvastatin hemicalcium salt treatment. The gene expression data were from GEO datasets GSE24188 and the TF prediction was by ChEA3. The bar showed rank score and the line showed the number of overlapped genes.

  • 1/16

    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Dec 25;8(1):457. [Abstract]

    Customer Validation
     EGFRvIII-high U87 cells were cocultured with EGFRvIII-CAR-T cells and treated with Atorvastatin (5 μM, 3 days) or Cytochalasin D (10 μg/mL, 1 day). Immunoblotting of magnetically separated cells showed that both drugs alleviated CAR molecule transfer (representative of three independent experiments).

  • 1/16

    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2023 Jan 1:552:215976. [Abstract]

    Customer Validation
     Panc-1 and MIA PaCa-2 cells were treated with Atorvastatin (20 μM or 50 μM) for 24 h. FOXM1 and mutant p53 protein levels were measured in different treatment groups.

  • 1/16

    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Oncogene. 2022 Dec;41(49):5266-5278. [Abstract]

    Customer Validation
     ATP assay. The combination of Atorvastatin (2.5, 5, 10, 20 μM; 48 h) and SR1078 synergistically inhibits CRC cell viability.

  • 1/16

    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. [Abstract]

    Customer Validation
     Tumor volumes of indicated patient-derived xenografts (PDXs) treated with Atorvastatin (40 mg/kg, i.p., every two days for 30 days).

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    Atorvastatin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Endocrinology. 2018 May 1;159(5):2008-2021. [Abstract]

    Customer Validation
     Male C57BL/6 mice are intragastrically treated with Atorvastatin (0.1 mg/kg/day) and placebo for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection. H&E and oil red O staining of frozen liver sections.

  • Atorvastatin hemicalcium salt