2. Metabolic Enzyme/Protease Autophagy Apoptosis
  3. HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
  4. Atorvastatin hemicalcium salt

Atorvastatin hemicalcium salt  (Synonyms: CI-981; Atorvastatin hemicalcium)

Cat. No.: HY-17379 Purity: 99.67％
COA Handling Instructions

Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.

For research use only. We do not sell to patients.

Atorvastatin hemicalcium salt Chemical Structure

Atorvastatin hemicalcium salt Chemical Structure

CAS No. : 134523-03-8

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10 mM * 1 mL in DMSO USD 61 In-stock
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10 mg USD 55 In-stock
50 mg USD 77 In-stock
100 mg USD 132 In-stock
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500 mg USD 418 In-stock
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Customer Review

Based on 26 publication(s) in Google Scholar

Other Forms of Atorvastatin hemicalcium salt:

Atorvastatin hemicalcium salt Related Antibodies

Top Publications Citing Use of Products

    Atorvastatin hemicalcium salt purchased from MCE. Usage Cited in: Oncogene. 2022 Oct 31.  [Abstract]

    ATP assay. The combination of Atorvastatin (2.5, 5, 10, 20 μM; 48 h) and SR1078 synergistically inhibits CRC cell viability.

    Atorvastatin hemicalcium salt purchased from MCE. Usage Cited in: Endocrinology. 2018 May 1;159(5):2008-2021.  [Abstract]

    Male C57BL/6 mice are intragastrically treated with Atorvastatin (0.1 mg/kg/day) and placebo for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection. H&E and oil red O staining of frozen liver sections.

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    Description

    Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

    In Vitro

    Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Atorvastatin hemicalcium salt Related Antibodies
    In Vivo

    Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE−/− mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Forty 8-week-old ApoE−/− mice induced with angiotensin II (Ang II)[5]
    Dosage: 20 mg/kg, 30 mg/kg
    Administration: Oral gavage; once a day; for 28 days
    Result: Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE−/− mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited
    Clinical Trial
    Molecular Weight

    577.67

    Appearance

    Solid

    Formula

    C33H34Ca0.5FN2O5
    CAS No.
    SMILES

    FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (86.55 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7311 mL 8.6555 mL 17.3109 mL
    5 mM 0.3462 mL 1.7311 mL 3.4622 mL
    10 mM 0.1731 mL 0.8655 mL 1.7311 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.93%

    COA (261 KB) LCMS (265 KB)

    Handling Instructions (2659 KB)
    References
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    Atorvastatin hemicalcium salt Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Atorvastatin hemicalcium134523-03-8CI-981 Atorvastatin hemicalciumCI981CI 981HMG-CoA Reductase (HMGCR)AutophagyFerroptosisInhibitorinhibitorinhibit

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