1. Metabolic Enzyme/Protease
    Autophagy
  2. HMG-CoA Reductase (HMGCR)
    Autophagy
  3. Atorvastatin hemicalcium salt

Atorvastatin hemicalcium salt (Synonyms: CI-981; Atorvastatin hemicalcium)

Cat. No.: HY-17379 Purity: 99.98%
Handling Instructions

Atorvastatin hemicalcium salt is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM.

For research use only. We do not sell to patients.

Atorvastatin hemicalcium salt Chemical Structure

Atorvastatin hemicalcium salt Chemical Structure

CAS No. : 134523-03-8

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10 mM * 1 mL in DMSO USD 66 In-stock
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50 mg USD 106 In-stock
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100 mg USD 168 In-stock
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200 mg USD 288 In-stock
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500 mg USD 624 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Atorvastatin hemicalcium salt:

Top Publications Citing Use of Products

Publications Citing Use of MCE Atorvastatin hemicalcium salt

    Atorvastatin hemicalcium salt purchased from MCE. Usage Cited in: Endocrinology. 2018 May 1;159(5):2008-2021.

    Male C57BL/6 mice are intragastrically treated with Atorvastatin (0.1 mg/kg/day) and placebo for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection. H&E and oil red O staining of frozen liver sections.
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Atorvastatin hemicalcium salt is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM.

    IC50 & Target

    IC50: 8 nM (HMG-CoA)

    In Vitro

    Atorvastatin (0.03 to 1 µM) inhibits FCS-induced SV-SMC proliferation and invasion[2]. Atorvastatin promotes the expansion of myeloid-derived suppressor cells (MDSCs) in vitro. Atorvastatin-derived MDSCs suppressed T cell responses by NO production[3].

    In Vivo

    Atorvastatin (1-90 mg/kg, p.o.) reduces the mechanical inflammatory hypernociception induced by LPS in a dose-dependent manner. Atorvastatin (30 mg/kg, p.o.) shows Antinociceptive effect of atorvastatin is mediated by inhibition of HMG-CoA reductase[1]. Atorvastatin promotes MDSCs accumulation in C57BL/6 mice[3].

    Clinical Trial
    Molecular Weight

    577.67

    Formula

    C₃₃H₃₄Ca₀.₅FN₂O₅

    CAS No.

    134523-03-8

    SMILES

    FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[[email protected]@H](O)C[[email protected]@H](O)CC([O-])=O)C=C1.[0.5Ca2+]

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (86.55 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7311 mL 8.6555 mL 17.3109 mL
    5 mM 0.3462 mL 1.7311 mL 3.4622 mL
    10 mM 0.1731 mL 0.8655 mL 1.7311 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Cell Assay
    [2]

    Briefly, SV-SMC from 5 different patients are seeded into 24-well cell culture plates at a density of 1×104 cells per well in full growth medium. Cells are incubated overnight and then quiesced in serum free medium for 3 days before transfer to full growth medium (10% FCS) containing 5 different statins (simvastatin, atorvastatin, fluvastatin, lovastatin, and pravastatin)at a range of concentrations. All statins are tested on cells from each individual patient. Medium and drugs are replaced after 2 days, and viable cell numbers are determined in triplicate wells after 4 days using Trypan Blue and a hemocytometer. The increase in cell number is calculated by subtracting the starting cell number (day 0) from the final cell number (day 4). Data are then normalized to control values (no statin) to correct for differences in proliferation rates between cells from different patients.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [1]

    To investigate the effect of atorvastatin on lipopolysaccharide (LPS)-induced inflammatory hypernociception, mice are pretreated orally with either atorvastatin, at doses of 1, 3, 10, 30 and 90 mg/kg or vehicle (PBS) once a day for 3 consecutive days. At 2 h after the last dose of atorvastatin, mice receive an i.pl. injection of LPS (100 ng/paw) or saline (vehicle for LPS). The animals are also treated with atorvastatin (30 mg/kg) for 1 or 2 days before LPS challenge. The hypernociceptive responses are assessed 0.5, 1, 3, 5, 7 and 24 h after LPS or saline i.pl. injections.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 99.98%

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    Product Name:
    Atorvastatin hemicalcium salt
    Cat. No.:
    HY-17379
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