1. Metabolic Enzyme/Protease
    Apoptosis
    Autophagy
  2. HMG-CoA Reductase (HMGCR)
    Ferroptosis
    Autophagy
  3. Atorvastatin hemicalcium salt

Atorvastatin hemicalcium salt (Synonyms: CI-981; Atorvastatin hemicalcium)

Cat. No.: HY-17379 Purity: 99.98%
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Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.

For research use only. We do not sell to patients.

Atorvastatin hemicalcium salt Chemical Structure

Atorvastatin hemicalcium salt Chemical Structure

CAS No. : 134523-03-8

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10 mM * 1 mL in DMSO USD 66 In-stock
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50 mg USD 106 In-stock
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100 mg USD 168 In-stock
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200 mg USD 288 In-stock
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500 mg USD 624 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Atorvastatin hemicalcium salt:

Top Publications Citing Use of Products

Publications Citing Use of MCE Atorvastatin hemicalcium salt

    Atorvastatin hemicalcium salt purchased from MCE. Usage Cited in: Endocrinology. 2018 May 1;159(5):2008-2021.

    Male C57BL/6 mice are intragastrically treated with Atorvastatin (0.1 mg/kg/day) and placebo for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection. H&E and oil red O staining of frozen liver sections.
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    Description

    Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

    In Vitro

    Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation[4].

    In Vivo

    Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE−/− mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment[5].

    Animal Model: Forty 8-week-old ApoE−/− mice induced with angiotensin II (Ang II)[5]
    Dosage: 20 mg/kg, 30 mg/kg
    Administration: Oral gavage; once a day; for 28 days
    Result: Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE−/− mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited
    Clinical Trial
    Molecular Weight

    577.67

    Formula

    C₃₃H₃₄Ca₀.₅FN₂O₅

    CAS No.

    134523-03-8

    SMILES

    FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[[email protected]@H](O)C[[email protected]@H](O)CC([O-])=O)C=C1.[0.5Ca2+]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (86.55 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7311 mL 8.6555 mL 17.3109 mL
    5 mM 0.3462 mL 1.7311 mL 3.4622 mL
    10 mM 0.1731 mL 0.8655 mL 1.7311 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.98%

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    Keywords:

    Atorvastatin hemicalciumCI-981CI981CI 981HMG-CoA Reductase (HMGCR)FerroptosisAutophagyInhibitorinhibitorinhibit

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