Atorvastatin hemicalcium trihydrate

Name: Atorvastatin hemicalcium trihydrate
Brand: MedChemExpress
SKU: HY-B0589E
Rating: 5.0 (63 reviews)

Cat. No.: HY-B0589E Purity: 99.70%: Data Sheet
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Atorvastatin hemicalcium trihydrate is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium trihydrate inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively.

For research use only. We do not sell to patients.

CAS No. : 344920-08-7

Size	Stock	Quantity
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 63 publication(s) in Google Scholar

Other Forms of Atorvastatin hemicalcium trihydrate:

63 Publications Citing Use of MCE Atorvastatin hemicalcium trihydrate

In Vivo Efficacy Study

Flow Cytometry

ELISA

Histological Imaging/Staining

Bio/Physico-chemical Assay

Cell Proliferation/Viability Assay

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Oct;7(10):2142-2164.; Representative histogram and quantification of normalized MHC I membrane levels determined by flow cytometry (stained for anti-HLA-A, anti-HLA-B and anti-HLA-C) in response to indicated treatment conditions in iAstrocytes (N = 4–6; three (control and cholesterol) or two (Atorvastatin hemicalcium salt) independent experiments from two isogenic sets. Data are shown as the mean. *P < 0.05 (two-sided one-sample t-test for cholesterol and atorvastatin versus 1).

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Oct;7(10):2142-2164.; Secreted Il-6 levels in medium of ApoE3 iAstrocytes that were pretreated with or without exogenous Cholesterol (10 μM) or Atorvastatin hemicalcium salt (0.5 μM) for 1 h before 24-h cotreatment with increasing doses of TNF, IL-1α and C1q.

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Environ Sci Technol Lett. 2025 Apr 8.; The hCMEC-D3 cells were exposed to 0.01 μM 77PD-Q for 24 h in the presence or absence of 0.3 μM Atorvastatin (0.3 μM, 24 h).

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Oct:146:157128. [Abstract]; ApoE^-/- mice were administrated with high-fat-diet accompanied by MFEVLPs (5 or 50 μg/d, i.p) or Atorvastatin (10 mg/kg/day, i.g) for 12 weeks.

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jul 5:e2403451. [Abstract]; Representative images of p-AKT1 staining of liver sections of the DMSO, Simvastatin and Atorvastatin hemicalcium salt (20 mg/kg, 3 days, atorvastatin with HFD)‐treated mice.

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jul 5:e2403451. [Abstract]; Western blotting of PAQR9 in mouse primary hepatocytes under the treatment of DMSO, Simvastatin (Sim), Atorvastatin hemicalcium salt (Ator, 10 mmol/L, 24-48 h) and Rosuvastatin (Rosu).

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jul 5:e2403451. [Abstract]; The top 20 predicted transcription factors of differentially expressed genes under Atorvastatin hemicalcium salt treatment. The gene expression data were from GEO datasets GSE24188 and the TF prediction was by ChEA3. The bar showed rank score and the line showed the number of overlapped genes.

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Dec 25;8(1):457. [Abstract]; EGFRvIII-high U87 cells were cocultured with EGFRvIII-CAR-T cells and treated with Atorvastatin (5 μM, 3 days) or Cytochalasin D (10 μg/mL, 1 day). Immunoblotting of magnetically separated cells showed that both drugs alleviated CAR molecule transfer (representative of three independent experiments).

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2023 Jan 1:552:215976. [Abstract]; Panc-1 and MIA PaCa-2 cells were treated with Atorvastatin (20 μM or 50 μM) for 24 h. FOXM1 and mutant p53 protein levels were measured in different treatment groups.

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2022 Dec;41(49):5266-5278. [Abstract]; ATP assay. The combination of Atorvastatin (2.5, 5, 10, 20 μM; 48 h) and SR1078 synergistically inhibits CRC cell viability.

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. [Abstract]; Tumor volumes of indicated patient-derived xenografts (PDXs) treated with Atorvastatin (40 mg/kg, i.p., every two days for 30 days).

: Atorvastatin hemicalcium trihydrate purchased from MedChemExpress. Usage Cited in: Endocrinology. 2018 May 1;159(5):2008-2021. [Abstract]; Male C57BL/6 mice are intragastrically treated with Atorvastatin (0.1 mg/kg/day) and placebo for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection. H&E and oil red O staining of frozen liver sections.

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Purity & Documentation
References
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Description

In Vitro

Atorvastatin hemicalcium trihydrate treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE^−/− mice) hemicalcium trihydrate treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Forty 8-week-old ApoE^−/− mice induced with angiotensin II (Ang II)^[5]
Dosage:	20 mg/kg, 30 mg/kg
Administration:	Oral gavage; once a day; for 28 days
Result:	Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE^−/− mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited.

Molecular Weight

632.73

Formula

C₃₃H₃₅FN₂O₅.1/2Ca.3H₂O

CAS No.

344920-08-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C(C1=CC=CC=C1)=C(C2=CC=C(F)C=C2)N3CC[C@@H](O)C[C@@H](O)CC(O)=O)=C3C(C)C)NC4=CC=CC=C4.[1/2].[Ca].O.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.70%

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Data Sheet (279 KB) SDS (252 KB)

COA (258 KB) HNMR (317 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. [Content Brief]

[2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [Content Brief]

[3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [Content Brief]

[4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. [Content Brief]

[5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. [Content Brief]