Atorvastatin strontium
Based on 57 publication(s) in Google Scholar
Strontium atorvastatin is a cholesterol-lowering drug with activity in ameliorating cardiovascular disease-related events. Strontium atorvastatin exerts its biological activity by inhibiting HMG-CoA reductase in liver tissue. Strontium atorvastatin is also used to suppress dyslipidemia.
For research use only. We do not sell to patients.
- CAS No.: 1072903-92-4
- Formula: C33H35FN2O5.1/2Sr
- Molecular Weight:602.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Atorvastatin strontium
More- Signal Transduct Target Ther. 2025 Nov 12;10(1):366. [Abstract]
- Signal Transduct Target Ther. 2023 Dec 25;8(1):457. [Abstract]
- Nat Neurosci. 2026 Jun;29(6):1369-1385.
- Nat Aging. 2025 Aug 26. [Abstract]
- Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. [Abstract]
- MedComm (2020). 2024 Aug 31;5(9):e681. [Abstract]
- Cancer Lett. 2023 Jan 1:552:215976. [Abstract]
- Environ Sci Technol Lett. 2025 Apr 8.
- Acta Pharmacol Sin. 2024 Jun;45(6):1316-1320. [Abstract]
- Phytomedicine. 2025 Oct:146:157128. [Abstract]
- Phytomedicine. 2025 Jul:142:156713. [Abstract]
- Phytomedicine. 2023 Jul 26;119:154997. [Abstract]
- Emerg Microbes Infect. 2025 Dec;14(1):2470371. [Abstract]
- Biomed Pharmacother. 2023 Oct:166:115323. [Abstract]
- Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658. [Abstract]
- Oncogene. 2022 Dec;41(49):5266-5278. [Abstract]
- Clin Pharmacol Ther. 2025 Jul 14. [Abstract]
- Chem Biol Interact. 2025 Oct 22:420:111671. [Abstract]
- Life Sci. 2025 Jun 1:370:123571. [Abstract]
- Inflammation. 2024 Oct 31. [Abstract]
- Int J Mol Sci. 2023 Apr 19;24(8):7492. [Abstract]
- Ann N Y Acad Sci. 2026 Mar;1557(1):e70224. [Abstract]
- Front Pharmacol. 2025 Apr 30:16:1573032. [Abstract]
- Int Immunopharmacol. 2026 Apr 1:174:116346. [Abstract]
- Int Immunopharmacol. 2025 Dec 3:166:115644. [Abstract]
- Eur J Pharmacol. 2025 Feb 5:177357. [Abstract]
- Eur J Pharmacol. 2024 Feb 5:964:176261. [Abstract]
- Eur J Pharmacol. 2023 Oct 5:956:175938. [Abstract]
- Nanomedicine. 2026 Mar;21(6):789-801. [Abstract]
- Front Cell Dev Biol. 2022 Mar 3;10:806081. [Abstract]
- FASEB J. 2026 May 15;40(9):e71873.
- Exp Neurol. 2025 May 16:115305. [Abstract]
- Proteomics. 2023 Aug;23(16):e2300041. [Abstract]
- Sci Rep. 2020 Jan 28;10(1):1308. [Abstract]
- J Virol. 2026 Jun 9:e0030126.
- J Nat Prod. 2022 Jul 22;85(7):1738-1750. [Abstract]
- Biotechnol Bioeng. 2021 Dec;118(12):4687-4698. [Abstract]
- Exp Cell Res. 2023 Dec 15;433(2):113829. [Abstract]
- Cell Cycle. 2021 Oct;20(20):2160-2173. [Abstract]
- Cell Cycle. 2019 Dec;18(23):3337-3350. [Abstract]
- Endocrinology. 2022 Jul 1;163(7):bqac076. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396(12):3659-3670. [Abstract]
- J Tradit Complement Med. 2024 Mar 29;14(6):656-665. [Abstract]
- Acta Diabetol. 2025 Mar 27. [Abstract]
- Med Gas Res. 2025 Mar 1;15(1):148-155. [Abstract]
- J Appl Toxicol. 2024 Aug;44(8):1198-1213. [Abstract]
- J Mol Neurosci. 2022 Mar;72(3):565-573. [Abstract]
- Oncologie. 2025 May 26.
- J Neuroimmunol. 2020 Oct 24:350:577429. [Abstract]
- FEBS Open Bio. 2025 Aug 8. [Abstract]
- SSRN. 2026 May 20.
- Res Sq. 2026 Jan 9.
- SSRN. 2025 Apr 9.
- Orebro University. 2024.
- Research Square Preprint. 2024 Apr 9.
- Research Square Preprint. 2022 Jun.
- Research Square Preprint. 2021 Dec.
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In Vivo Efficacy Study
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Cell Proliferation/Viability Assay
Biological Activity
Chemical Information
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CAS No. 1072903-92-4
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Molecular Weight 602.06
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Formula C33H35FN2O5.1/2Sr
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SMILES
O=C(C1=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C2=CC=C(C=C2)F)=C1C3=CC=CC=C3)NC4=CC=CC=C4.[1/2Sr]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (57)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2025 Nov 12;10(1):366. PMID: 41219186 -
Signal Transduct Target Ther
2023 Dec 25;8(1):457. PMID: 38143263
Atorvastatin strontium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Dec 25;8(1):457. [Abstract]
EGFRvIII-high U87 cells were cocultured with EGFRvIII-CAR-T cells and treated with Atorvastatin (5 μM, 3 days) or Cytochalasin D (10 μg/mL, 1 day). Immunoblotting of magnetically separated cells showed that both drugs alleviated CAR molecule transfer (representative of three independent experiments).
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Nat Aging
2025 Aug 26. PMID: 40858817 -
Mol Cell
The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability. [Abstract]2021 Jul 1;81(13):2736-2751.e8. PMID: 33932349
Atorvastatin strontium purchased from MedChemExpress. Usage Cited in: Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. [Abstract]
Tumor volumes of indicated patient-derived xenografts (PDXs) treated with Atorvastatin (40 mg/kg, i.p., every two days for 30 days).
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MedComm (2020)
Statins, but not proprotein convertase subtilisin-kexin type 9 inhibitors, lower chemerin in hypercholesterolemia via low-density lipoprotein receptor upregulation. [Abstract]2024 Aug 31;5(9):e681. PMID: 39220103 -
Cancer Lett
Mutant p53 driven-LINC00857, a protein scaffold between FOXM1 and deubiquitinase OTUB1, promotes the metastasis of pancreatic cancer. [Abstract]2023 Jan 1:552:215976. PMID: 36272615
Atorvastatin strontium purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2023 Jan 1:552:215976. [Abstract]
Panc-1 and MIA PaCa-2 cells were treated with Atorvastatin (20 μM or 50 μM) for 24 h. FOXM1 and mutant p53 protein levels were measured in different treatment groups.
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Atorvastatin strontium purchased from MedChemExpress. Usage Cited in: Environ Sci Technol Lett. 2025 Apr 8.
The hCMEC-D3 cells were exposed to 0.01 μM 77PD-Q for 24 h in the presence or absence of 0.3 μM Atorvastatin (0.3 μM, 24 h).
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Acta Pharmacol Sin
2024 Jun;45(6):1316-1320. PMID: 38459255 -
Phytomedicine
Mori fructus-derived extracellular vesicle-like nanoparticles regulate dyslipidemia and prevent atherosclerosis progression via miRNAs. [Abstract]2025 Oct:146:157128. PMID: 40815949
Atorvastatin strontium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Oct:146:157128. [Abstract]
ApoE-/- mice were administrated with high-fat-diet accompanied by MFEVLPs (5 or 50 μg/d, i.p) or Atorvastatin (10 mg/kg/day, i.g) for 12 weeks.
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Phytomedicine
Bioactive equivalent combinatorial components of Xiao-Xu-Ming decoction inhibit the calmodulin-mediated MLCK/MLC axis to attenuate coronary artery spasm. [Abstract]2025 Jul:142:156713. PMID: 40349422 -
Phytomedicine
Dihydromyricetin confers cerebroprotection against subarachnoid hemorrhage via the Nrf2-dependent Prx2 signaling cascade. [Abstract]2023 Jul 26;119:154997. PMID: 37523836 -
Emerg Microbes Infect
SREBP2-dependent lipid droplet formation enhances viral replication and deteriorates lung injury in mice following IAV infection. [Abstract]2025 Dec;14(1):2470371. PMID: 39968754 -
Biomed Pharmacother
2023 Oct:166:115323. PMID: 37579692 -
Arterioscler Thromb Vasc Biol
N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) as a Novel Mediator of Statin Effects in Human Endothelial Cells. [Abstract]2022 May;42(5):644-658. PMID: 35296150 -
Oncogene
Targeting the cholesterol-RORα/γ axis inhibits colorectal cancer progression through degrading c-myc. [Abstract]2022 Dec;41(49):5266-5278. PMID: 36316442
Atorvastatin strontium purchased from MedChemExpress. Usage Cited in: Oncogene. 2022 Dec;41(49):5266-5278. [Abstract]
ATP assay. The combination of Atorvastatin (2.5, 5, 10, 20 μM; 48 h) and SR1078 synergistically inhibits CRC cell viability.
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Clin Pharmacol Ther
Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter-Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™). [Abstract]2025 Jul 14. PMID: 40657937 -
Chem Biol Interact
Subchronic exposure to CeCl3 promotes macrophage ferroptosis and atherosclerotic plaque formation by inhibiting the Keap1/Nrf2/GPX4 pathway. [Abstract]2025 Oct 22:420:111671. PMID: 40706741 -
Life Sci
CKN reduces TLR4-mediated inflammation and cerebral I/R injury by activating the LXRα/ABCA1 pathway in microglia. [Abstract]2025 Jun 1:370:123571. PMID: 40107493 -
Inflammation
2024 Oct 31. PMID: 39480573 -
Int J Mol Sci
Effects of Dietary Cholesterol Regulation on Spermatogenesis of Gobiocypris rarus Rare Minnow. [Abstract]2023 Apr 19;24(8):7492. PMID: 37108655 -
Ann N Y Acad Sci
The TRIB1-PPARγ Axis Regulates Cholesterol Metabolism in Pancreatic Ductal Adenocarcinoma. [Abstract]2026 Mar;1557(1):e70224. PMID: 41774091 -
Front Pharmacol
Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells. [Abstract]2025 Apr 30:16:1573032. PMID: 40371351 -
Int Immunopharmacol
Milk exosomes loaded with atorvastatin suppress fibroblast activation and extracellular matrix remodeling via the TGF-β/SMAD pathway in ligamentum flavum hypertrophy. [Abstract]2026 Apr 1:174:116346. PMID: 41707594 -
Int Immunopharmacol
Structural polysaccharide PCP1 from Polygonatum cyrtonema Hua attenuates atherosclerosis via dual-target suppression of CD36/MSR1 and TLR4/NF-κB pathways. [Abstract]2025 Dec 3:166:115644. PMID: 41045802 -
Eur J Pharmacol
Protective effects of atorvastatin on testicular dysfunction and reduced sperm quality induced by high-fat diet in mice: The inhibitory mechanism of oxidative stress. [Abstract]2025 Feb 5:177357. PMID: 39921059 -
Eur J Pharmacol
Atorvastatin exerts dual effects of lesion regression and ovarian protection in the prevention and treatment of endometriosis. [Abstract]2024 Feb 5:964:176261. PMID: 38141938 -
Eur J Pharmacol
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE-/- mice via suppressing inflammation, endothelial necroptosis and apoptosis. [Abstract]2023 Oct 5:956:175938. PMID: 37536623 -
Nanomedicine
Precise atorvastatin delivery by cardiac homing peptide functionalized nanoliposomes for myocardial damage repair after myocardial infarction. [Abstract]2026 Mar;21(6):789-801. PMID: 41660754 -
Front Cell Dev Biol
Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis. [Abstract]2022 Mar 3;10:806081. PMID: 35309902 -
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Exp Neurol
Salvianolic acid B exerts cerebroprotective effects after traumatic brain injury via Nrf2-dependent antioxidant and anti-inflammatory cascades. [Abstract]2025 May 16:115305. PMID: 40383364 -
Proteomics
A proteomic signature and potential pharmacological opportunities in the adaptive resistance to MEK and PI3K kinase inhibition in pancreatic cancer cells. [Abstract]2023 Aug;23(16):e2300041. PMID: 37140101 -
Sci Rep
Scutellarin inhibition of the rosuvastatin uptake in rat hepatocytes and the competition for organic anion transporting polypeptide 1B1 in HEK293T cells. [Abstract]2020 Jan 28;10(1):1308. PMID: 31992796 -
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J Nat Prod
Xyloketal B Reverses Nutritional Hepatic Steatosis, Steatohepatitis, and Liver Fibrosis through Activation of the PPARα/PGC1α Signaling Pathway. [Abstract]2022 Jul 22;85(7):1738-1750. PMID: 35749236 -
Biotechnol Bioeng
An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. [Abstract]2021 Dec;118(12):4687-4698. PMID: 34478150 -
Exp Cell Res
Rapamycin promotes hematoma resorption and enhances endothelial cell function by suppressing the mTOR/STAT3 signaling in chronic subdural hematoma. [Abstract]2023 Dec 15;433(2):113829. PMID: 37879548 -
Cell Cycle
Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. [Abstract]2021 Oct;20(20):2160-2173. PMID: 34494933 -
Cell Cycle
Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response. [Abstract]2019 Dec;18(23):3337-3350. PMID: 31599189 -
Endocrinology
2022 Jul 1;163(7):bqac076. PMID: 35583599 -
Naunyn Schmiedebergs Arch Pharmacol
Bisdemethoxycurcumin suppresses the progression of atherosclerosis and VSMC-derived foam cell formation by promoting lipophagy. [Abstract]2023 Dec;396(12):3659-3670. PMID: 37289282 -
J Tradit Complement Med
Zhilong Huoxue Tongyu capsule protects against atherosclerosis by suppressing EndMT via modulating Hippo/YAP signaling pathway. [Abstract]2024 Mar 29;14(6):656-665. PMID: 39850597 -
Acta Diabetol
Identification of FLVCR1 as the iron metabolism-related gene of statin-associated diabetes. [Abstract]2025 Mar 27. PMID: 40146399 -
Med Gas Res
The augment effects of magnesium hydride on the lipid lowering effect of atorvastatin: an in vivo and in vitro investigation. [Abstract]2025 Mar 1;15(1):148-155. PMID: 39436189 -
J Appl Toxicol
2024 Aug;44(8):1198-1213. PMID: 38639436 -
J Mol Neurosci
Atorvastatin-Induced Absorption of Chronic Subdural Hematoma Is Partially Attributed to the Polarization of Macrophages. [Abstract]2022 Mar;72(3):565-573. PMID: 34569007 -
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J Neuroimmunol
The combined treatment of NAD+ and atorvastatin ameliorates the development of experimental autoimmune encephalomyelitis in C57BL/6 mice. [Abstract]2020 Oct 24:350:577429. PMID: 33176238 -
FEBS Open Bio
Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis. [Abstract]2025 Aug 8. PMID: 40781787 -
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Purity & Documentation
References
[1]. Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. [Content Brief]
[2]. Systemic drugs with impact on osteoarthritis [Content Brief]
[3]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [Content Brief]
[4]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [Content Brief]
[5]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. [Content Brief]
[6]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. [Content Brief]
[7]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)