1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. (3S,5S)-Atorvastatin

(3S,5S)-Atorvastatin 

Cat. No.: HY-B0589C Purity: >95.0%
Handling Instructions

(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.

For research use only. We do not sell to patients.

(3S,5S)-Atorvastatin Chemical Structure

(3S,5S)-Atorvastatin Chemical Structure

CAS No. : 501121-34-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 295 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (3S,5S)-Atorvastatin:

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Description

(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

IC50 & Target

Pregnane X receptor (PXR)[1]

In Vitro

Atorvastatin and its inactive enantiomer (3S,5S)-Atorvastatin increases CYP2B and CYP3A mRNA content with equal ability[1].
(3S,5S)-Atorvastatin in 100 μM concentrations induces luciferase activity with an EC50 of 12.4 μM[2].
Addition of (3S,5S)-Atorvastatin to the 2-formylphenylboronic acid (FPBA)/l-tryptophanol mixture induces an intensity enhancement of l-tryptophanol florescence[3].

Molecular Weight

558.64

Formula

C₃₃H₃₅FN₂O₅

CAS No.

501121-34-2

SMILES

O=C(C(C(C1=CC=CC=C1)=C(C2=CC=C(F)C=C2)N3CC[[email protected]](O)C[[email protected]](O)CC(O)=O)=C3C(C)C)NC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (223.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7901 mL 8.9503 mL 17.9006 mL
5 mM 0.3580 mL 1.7901 mL 3.5801 mL
10 mM 0.1790 mL 0.8950 mL 1.7901 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

(3S,5S)-AtorvastatinCytochrome P450CYPsNuclearreceptorPXRenantiomerinactiveCYP2BCYP3AluciferaseFPBAl-tryptophanolInhibitorinhibitorinhibit

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(3S,5S)-Atorvastatin
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HY-B0589C
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