1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. (3S,5S)-Atorvastatin

(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.

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(3S,5S)-Atorvastatin Chemical Structure

(3S,5S)-Atorvastatin Chemical Structure

CAS No. : 501121-34-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 246 In-stock
Solution
10 mM * 1 mL in DMSO USD 246 In-stock
Solid
5 mg USD 200 In-stock
10 mg USD 300 In-stock
50 mg USD 750 In-stock
100 mg USD 1125 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (3S,5S)-Atorvastatin:

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Description

(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

IC50 & Target

Pregnane X receptor (PXR)[1]

In Vitro

Atorvastatin and its inactive enantiomer (3S,5S)-Atorvastatin increases CYP2B and CYP3A mRNA content with equal ability[1].
(3S,5S)-Atorvastatin in 100 μM concentrations induces luciferase activity with an EC50 of 12.4 μM[2].
Addition of (3S,5S)-Atorvastatin to the 2-formylphenylboronic acid (FPBA)/l-tryptophanol mixture induces an intensity enhancement of l-tryptophanol florescence[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

558.64

Formula

C33H35FN2O5

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C(C(C1=CC=CC=C1)=C(C2=CC=C(F)C=C2)N3CC[C@H](O)C[C@H](O)CC(O)=O)=C3C(C)C)NC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (223.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7901 mL 8.9503 mL 17.9006 mL
5 mM 0.3580 mL 1.7901 mL 3.5801 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7901 mL 8.9503 mL 17.9006 mL 44.7515 mL
5 mM 0.3580 mL 1.7901 mL 3.5801 mL 8.9503 mL
10 mM 0.1790 mL 0.8950 mL 1.7901 mL 4.4752 mL
15 mM 0.1193 mL 0.5967 mL 1.1934 mL 2.9834 mL
20 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2376 mL
25 mM 0.0716 mL 0.3580 mL 0.7160 mL 1.7901 mL
30 mM 0.0597 mL 0.2983 mL 0.5967 mL 1.4917 mL
40 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
50 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8950 mL
60 mM 0.0298 mL 0.1492 mL 0.2983 mL 0.7459 mL
80 mM 0.0224 mL 0.1119 mL 0.2238 mL 0.5594 mL
100 mM 0.0179 mL 0.0895 mL 0.1790 mL 0.4475 mL
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(3S,5S)-Atorvastatin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(3S,5S)-Atorvastatin
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