2. Metabolic Enzyme/Protease
  3. Stearoyl-CoA Desaturase (SCD)
  4. SC-26196

SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties.

For research use only. We do not sell to patients.

CAS No. : 218136-59-5

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of SC-26196:

SC-26196 Related Antibodies

Top Publications Citing Use of Products

    SC-26196 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2026 Mar 3;38(3):565-581.e5.  [Abstract]

    SC-26196 (100 mg/kg; i.g.; once daily) treatment significantly diminished the FAD-induced increase in tumor-infiltrating IFNγ+CD8+ T cells in tumor-bearing DIO mice receiving anti-PD-1 therapy.

    SC-26196 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2026 Mar 3;38(3):565-581.e5.  [Abstract]

    SC-26196 (100 mg/kg; i.g.; once daily), a selective FADS2 inhibitor, significantly increased the growth of MC38 tumor.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties[1].

    IC50 & Target

    IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)[1]
    In Vitro

    SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SC-26196 Related Antibodies

    Cell Proliferation Assay[2]

    Cell Line: PBMCs and Jurkat cells
    Concentration: 200 nM
    Incubation Time: 96 hours for PBMCs; 144 hours for Jurkat cells
    Result: Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
    Did not alter cell proliferation significantly in Jurkat cells.
    In Vivo

    SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male mice (12- or 15-week-old)[3]
    Dosage: 0, 10, 30, and 100 mg/kg per day
    Administration: Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day.
    Result: Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.
    Molecular Weight

    423.55

    Formula

    C27H29N5
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CC=CN=C4)CC3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (11.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3610 mL 11.8050 mL 23.6100 mL
    5 mM 0.4722 mL 2.3610 mL 4.7220 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 5 mg/mL (11.80 mM); Suspended solution; Need ultrasonic and warming and heat to 40°C

    • Protocol 2

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 10 mg/mL (23.61 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.66%

    SDS (393 KB)

    COA (248 KB) HNMR (271 KB) LCMS (91 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3610 mL 11.8050 mL 23.6100 mL 59.0249 mL
    5 mM 0.4722 mL 2.3610 mL 4.7220 mL 11.8050 mL
    10 mM 0.2361 mL 1.1805 mL 2.3610 mL 5.9025 mL
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    SC-26196 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SC-26196218136-59-5SC26196SC 26196Stearoyl-CoA Desaturase (SCD)FADS2Delta6desaturaseD6DinflammatorydiseaseAntiinflammatoryInhibitorinhibitorinhibit

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