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SC-26196 

Cat. No.: HY-107410
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SC-26196 is a potent, orally active Delta6 desaturase (D6D) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties.

For research use only. We do not sell to patients.

SC-26196 Chemical Structure

SC-26196 Chemical Structure

CAS No. : 218136-59-5

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Description

SC-26196 is a potent, orally active Delta6 desaturase (D6D) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties[1].

IC50 & Target

IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)[1]

In Vitro

SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells[2].

Cell Proliferation Assay[2]

Cell Line: PBMCs and Jurkat cells
Concentration: 200 nM
Incubation Time: 96 hours for PBMCs; 144 hours for Jurkat cells
Result: Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
Did not alter cell proliferation significantly in Jurkat cells.
In Vivo

SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme[3].

Animal Model: Male mice (12- or 15-week-old)[3]
Dosage: 0, 10, 30, and 100 mg/kg per day
Administration: Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day.
Result: Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.
Molecular Weight

423.55

Formula

C₂₇H₂₉N₅

CAS No.

218136-59-5

SMILES

N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CC=CN=C4)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SC-26196SC26196SC 26196OthersFADS2Delta6desaturaseD6DinflammatorydiseaseAntiinflammatoryInhibitorinhibitorinhibit

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SC-26196
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