SC-26196
Based on 5 publication(s) in Google Scholar
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 218136-59-5
- Formula: C27H29N5
- Molecular Weight:423.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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HY-L061
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Anti-Cancer Metabolism Compound Library
HY-L083
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Anti-Obesity Compound Library
HY-L087
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Lipid Metabolism Compound Library
HY-L091
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Targeted Diversity Library
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Heterocyclic Compound Library
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
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Bioactive Compound Library
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
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Publications Citing Use of MedChemExpress (MCE) SC-26196
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Customer Validation & Images
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Flow Cytometry
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In Vivo Efficacy Study
Biological Activity
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)[1]
SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PBMCs and Jurkat cells
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Concentration:200 nM
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Incubation Time:96 hours for PBMCs; 144 hours for Jurkat cells
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Result:Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
Did not alter cell proliferation significantly in Jurkat cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice (12- or 15-week-old)[3]
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Dosage:0, 10, 30, and 100 mg/kg per day
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Administration:Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day.
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Result:Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.
Chemical Information
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CAS No. 218136-59-5
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Appearance Solid
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Molecular Weight 423.55
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Formula C27H29N5
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Color Off-white to yellow
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SMILES
N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CC=CN=C4)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Metab
Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy. [Abstract]2026 Mar 3;38(3):565-581.e5. PMID: 41570815
SC-26196 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2026 Mar 3;38(3):565-581.e5. [Abstract]
SC-26196 (100 mg/kg; i.g.; once daily) treatment significantly diminished the FAD-induced increase in tumor-infiltrating IFNγ+CD8+ T cells in tumor-bearing DIO mice receiving anti-PD-1 therapy.
SC-26196 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2026 Mar 3;38(3):565-581.e5. [Abstract]
SC-26196 (100 mg/kg; i.g.; once daily), a selective FADS2 inhibitor, significantly increased the growth of MC38 tumor.
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Gastroenterology
2024 Jan 24:S0016-5085(24)00064-7. PMID: 38272100 -
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ACS Chem Biol
2026 Jun 12. PMID: 42284103 -
ACS Chem Biol
2024 Apr 19;19(4):896-907. PMID: 38506663
Solvent & Solubility
DMSO : 5 mg/mL (11.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 5 mg/mL (11.80 mM); Suspended solution; Need ultrasonic and warming and heat to 40°C
Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 10 mg/mL (23.61 mM); Suspended solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Obukowicz MG, et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther. 1998 Oct;287(1):157-66. [Content Brief]
[2]. Sibbons CM, et al. Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2018 Mar 5;9:432. [Content Brief]
[3]. Hargrave-Barnes KM, et al. Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase. Obesity (Silver Spring). 2008 Oct;16(10):2245-52. [Content Brief]
[4]. Zhang L, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.3610 mL | 11.8050 mL | 23.6100 mL | 59.0249 mL |
| 5 mM | 0.4722 mL | 2.3610 mL | 4.7220 mL | 11.8050 mL | |
| 10 mM | 0.2361 mL | 1.1805 mL | 2.3610 mL | 5.9025 mL |
SC-26196 Related Classifications
HY-107410 Related Classifications
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