SC-26196 (Standard)
SC-26196 (Standard) is the analytical standard of SC-26196 (HY-107410). This product is intended for research and analytical applications. SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties.
For research use only. We do not sell to patients.
- CAS No.: 218136-59-5
- Formula: C27H29N5
- Molecular Weight:423.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-107410
SC-26196Delta6 Desaturase Inhibitor -
HY-15823
CAY10566SCD1 Inhibitor -
HY-50709
A939572SCD1 Inhibitor -
HY-13070
MK-8245 -
HY-15822
MF-438SCD1 Inhibitor -
HY-101903
BMS-309403FABP4 Inhibitor -
HY-15700
PluriSIn 1Apoptosis Inducer -
HY-14452A
Fatostatin hydrobromideSREBP Activation Inhibitor -
HY-107613
R 59-022DGK Inhibitor -
HY-13077
MK-8245 Trifluoroacetate -
HY-100907
(±)-Acetylcarnitine chlorideLipid Metabolism Intermediate -
HY-101018
Propionyl-DL-carnitine chlorideCarnitine Derivative
Biological Activity
Description
IC50 & Target
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)[1]
Chemical Information
-
CAS No. 218136-59-5
-
Molecular Weight 423.55
-
Formula C27H29N5
-
SMILES
N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCN(/N=C/C4=CC=CN=C4)CC3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Obukowicz MG, et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther. 1998 Oct;287(1):157-66. [Content Brief]
[2]. Sibbons CM, et al. Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2018 Mar 5;9:432. [Content Brief]
[3]. Hargrave-Barnes KM, et al. Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase. Obesity (Silver Spring). 2008 Oct;16(10):2245-52. [Content Brief]
[4]. Zhang L, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SC-26196 (Standard) Related Classifications
HY-107410R Related Classifications
Powered by Bioz