Art. -Nr.: HY-15822

MF-438

Name: MF-438
Brand: MedChemExpress
SKU: HY-15822
Price: 130.00 USD
Availability: InStock
Rating: 5 (7 reviews)

7 Cited Publications

Kundenbewertung

Based on 7 publication(s) in Google Scholar

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC₅₀ of 2.3 nM for rSCD1.

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Reinheit: 99.83%
CAS. Nr.: 921605-87-0
Formel: C₁₉H₁₈F₃N₅OS
Molecular Weight:421.44

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

MF-438 Chemical Structure

CAS. Nr.: 921605-87-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC₅₀ of 2.3 nM for rSCD1^[1].

IC₅₀ & Target

EC₅₀: 2.3 nM (rSCD1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	157 nM Compound: 1, MF-438	Inhibition of SCD-1 activity in Sprague-Dawley rat Hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation counting Inhibition of SCD-1 activity in Sprague-Dawley rat Hepatocytes expressing organic anion transporting polypeptides assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation counting	[PMID: 21661758]
HepG2	IC₅₀	>100000 μM Compound: 1, MF-438	Inhibition of human delta6 desaturase activity expressed in human HEpG2 cells Inhibition of human delta6 desaturase activity expressed in human HEpG2 cells	[PMID: 21661758]
HepG2	IC₅₀	>100000 μM Compound: 1, MF-438	Inhibition of rat delta-5 desaturase activity expressed in human HEpG2 cells Inhibition of rat delta-5 desaturase activity expressed in human HEpG2 cells	[PMID: 21661758]
HepG2	IC₅₀	>100000 μM Compound: 1, MF-438	Inhibition of rat delta-6 desaturase activity expressed in human HEpG2 cells Inhibition of rat delta-6 desaturase activity expressed in human HEpG2 cells	[PMID: 21661758]
HepG2	IC₅₀	21 nM Compound: 1, MF-438	Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation counting Inhibition of SCD-1 activity in organic anion transporting polypeptides-deficient human HepG2 cells assessed as reduction in [I-14C] stearoyl CoA desaturation by scintillation counting	[PMID: 21661758]
HepG2	IC₅₀	>100000 μM Compound: 1, MF-438	Inhibition of human delta-5 desaturase activity expressed in human HEpG2 cells Inhibition of human delta-5 desaturase activity expressed in human HEpG2 cells	[PMID: 21661758]

In Vivo

MF-438 exhibits an ED₅₀ between 1 and 3 mg/kg in a mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 921605-87-0
Appearance Solid
Molecular Weight 421.44
Formel C₁₉H₁₈F₃N₅OS
Color Light yellow to orange
SMILES

FC(C1=CC=CC=C1OC2CCN(C3=NN=C(C4=NN=C(C)S4)C=C3)CC2)(F)F
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (7)

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Journal Impact Factor

Imeta

2026 Feb 19.
Gastroenterology

Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis. [Abstract]

2024 May;166(5):772-786.e14. PMID: 38272100
Cancer Discov

C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia. [Abstract]

2023 Jul 7;13(7):1720-1747. PMID: 37012202
Nat Cell Biol

Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition. [Abstract]

2024 Sep;26(9):1470-1481. PMID: 39009641
Nat Commun

Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer. [Abstract]

2026 May 11;17(1):4190. PMID: 42115216
EBioMedicine

Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor. [Abstract]

2022 Mar:77:103872. PMID: 35158113
J Ovarian Res

Oleic acid activates TGFβ-Smad3 signaling to promote ovarian cancer progression. [Abstract]

2025 Aug 11;18(1):180. PMID: 40790593

Lösungsmittel & Löslichkeit

In Vitro:

DMF : 50 mg/mL (118.64 mM; Need ultrasonic)

DMSO : 25 mg/mL (59.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3728 mL

11.8641 mL

23.7282 mL

5 mM

0.4746 mL

2.3728 mL

4.7456 mL

10 mM

0.2373 mL

1.1864 mL

2.3728 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMF 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 4.55 mg/mL (10.80 mM); Clear solution

Protocol 2

Add each solvent one by one: 10% DMF 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution

Protocol 3

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 4

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 5

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

This protocol yields a clear solution of ≥ 0.83 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (8.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / DMF	1 mM	2.3728 mL	11.8641 mL	23.7282 mL	59.3204 mL
	5 mM	0.4746 mL	2.3728 mL	4.7456 mL	11.8641 mL
	10 mM	0.2373 mL	1.1864 mL	2.3728 mL	5.9320 mL
	15 mM	0.1582 mL	0.7909 mL	1.5819 mL	3.9547 mL
	20 mM	0.1186 mL	0.5932 mL	1.1864 mL	2.9660 mL
	25 mM	0.0949 mL	0.4746 mL	0.9491 mL	2.3728 mL
	30 mM	0.0791 mL	0.3955 mL	0.7909 mL	1.9773 mL
	40 mM	0.0593 mL	0.2966 mL	0.5932 mL	1.4830 mL
	50 mM	0.0475 mL	0.2373 mL	0.4746 mL	1.1864 mL
DMF	60 mM	0.0395 mL	0.1977 mL	0.3955 mL	0.9887 mL
	80 mM	0.0297 mL	0.1483 mL	0.2966 mL	0.7415 mL
	100 mM	0.0237 mL	0.1186 mL	0.2373 mL	0.5932 mL

Bioz

Keywords

MF-438

7 Cited Publications

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CAS. Nr.:
Species:
Reinheit:
Menge:

MF-438

CAY10566

MK-8245

A939572

RSL3

Icomidocholic acid

SC-26196

SCD1 inhibitor-4

Ferrostatin-1

SCD1 inhibitor-1

SCD1 inhibitor-3

XEN723

YTX-465

Publications Citing Use of MedChemExpress (MCE) MF-438

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

MF-438

CAY10566

MK-8245

A939572

RSL3

Icomidocholic acid

SC-26196

SCD1 inhibitor-4

Ferrostatin-1

SCD1 inhibitor-1

SCD1 inhibitor-3

XEN723

YTX-465

Publications Citing Use of MedChemExpress (MCE) MF-438

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MF-438 Related Classifications

HY-15822 Related Classifications

Bioz